Is an epitope on keratin 17 a major target for autoreactive T lymphocytes in psoriasis?

2.50
Hdl Handle:
http://hdl.handle.net/2336/47078
Title:
Is an epitope on keratin 17 a major target for autoreactive T lymphocytes in psoriasis?
Authors:
Gudmundsdottir, A S; Sigmundsdottir, H; Sigurgeirsson, B; Good, M F; Valdimarsson, H; Jonsdottir, I
Citation:
Clin. Exp. Immunol. 1999, 117(3):580-6
Issue Date:
1-Sep-1999
Abstract:
Psoriasis is a T cell-mediated inflammatory skin disease that has been associated with infections by group A beta-haemolytic streptococci. In a previous study of patients with active psoriasis we demonstrated an increased frequency of circulating Th1-like cells that responded to 20 amino acid (aa) streptococcal M-peptides sharing sequences with human keratin. These cells disappeared after ultraviolet B (UVB)-induced clinical remission. Using T cells from the blood of 17 psoriatic patients and 17 healthy controls we have now compared the numbers of interferon-gamma (IFN-gamma)-producing cells induced by seven 18-20 aa keratin peptides and five corresponding M-peptides. The most frequent and strongest responses were observed to a peptide from keratin 17 that shares ALEEAN sequence with M-protein. The responses to this peptide were stronger than to the corresponding M-peptide containing the ALEEAN sequence. After UVB treatment T cell responses to all the M- and keratin peptides were abolished, while responses to the positive control antigen streptokinase/streptodornase (SK/SD) were not affected. These findings are consistent with the notion that aa sequences which keratin has in common with M-protein may be a major target for autoreactive T cells in psoriasis.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1905362

Full metadata record

DC FieldValue Language
dc.contributor.authorGudmundsdottir, A S-
dc.contributor.authorSigmundsdottir, H-
dc.contributor.authorSigurgeirsson, B-
dc.contributor.authorGood, M F-
dc.contributor.authorValdimarsson, H-
dc.contributor.authorJonsdottir, I-
dc.date.accessioned2009-01-06T13:24:08Z-
dc.date.available2009-01-06T13:24:08Z-
dc.date.issued1999-09-01-
dc.date.submitted2008-01-06-
dc.identifier.citationClin. Exp. Immunol. 1999, 117(3):580-6en
dc.identifier.issn0009-9104-
dc.identifier.pmid10469066-
dc.identifier.doi10.1046/j.1365-2249.1999.01013.x-
dc.identifier.urihttp://hdl.handle.net/2336/47078-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPsoriasis is a T cell-mediated inflammatory skin disease that has been associated with infections by group A beta-haemolytic streptococci. In a previous study of patients with active psoriasis we demonstrated an increased frequency of circulating Th1-like cells that responded to 20 amino acid (aa) streptococcal M-peptides sharing sequences with human keratin. These cells disappeared after ultraviolet B (UVB)-induced clinical remission. Using T cells from the blood of 17 psoriatic patients and 17 healthy controls we have now compared the numbers of interferon-gamma (IFN-gamma)-producing cells induced by seven 18-20 aa keratin peptides and five corresponding M-peptides. The most frequent and strongest responses were observed to a peptide from keratin 17 that shares ALEEAN sequence with M-protein. The responses to this peptide were stronger than to the corresponding M-peptide containing the ALEEAN sequence. After UVB treatment T cell responses to all the M- and keratin peptides were abolished, while responses to the positive control antigen streptokinase/streptodornase (SK/SD) were not affected. These findings are consistent with the notion that aa sequences which keratin has in common with M-protein may be a major target for autoreactive T cells in psoriasis.en
dc.language.isoenen
dc.publisherBlackwell Scientific Publicationsen
dc.relation.urlhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1905362en
dc.subject.meshAmino Acid Sequenceen
dc.subject.meshAntigens, Bacterialen
dc.subject.meshBacterial Outer Membrane Proteinsen
dc.subject.meshBacterial Proteinsen
dc.subject.meshCarrier Proteinsen
dc.subject.meshCells, Cultureden
dc.subject.meshEpitopes, T-Lymphocyteen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshKeratinsen
dc.subject.meshMaleen
dc.subject.meshMolecular Sequence Dataen
dc.subject.meshPeptidesen
dc.subject.meshPsoriasisen
dc.subject.meshT-Lymphocytesen
dc.subject.meshUltraviolet Raysen
dc.titleIs an epitope on keratin 17 a major target for autoreactive T lymphocytes in psoriasis?en
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, The National University Hospital, Reykjavik, Iceland.en
dc.identifier.journalClinical and experimental immunologyen

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