2.50
Hdl Handle:
http://hdl.handle.net/2336/47082
Title:
Molecular genetics of breast cancer progression
Authors:
Ingvarsson, S
Citation:
Semin. Cancer Biol. 1999, 9(4):277-88
Issue Date:
1-Aug-1999
Abstract:
Somatic changes in the genome of breast cancer cells include amplifications, deletions and gene mutations. Several chromosome regions harboring known oncogenes are found amplified in breast tumors. Despite the high number of chromosome regions deleted in breast tumors the functional relationship to known genes at these locations and cancer growth is mainly undiscovered. Mutations in two tumor suppressor genes (TSG) have been described in a subset of breast carcinomas. These TSG are the TP53, encoding the p53 transcription factor, and the CDH1, encoding the cadherin cell adhesion molecule. Breast tumors of patients with a germ-line mutation in the BRCA1 or BRCA2 gene have an increase of additional genetic defects compared with sporadic breast tumors. This higher frequency of genetic aberrations could pinpoint genes that selectively promote tumor progression in individuals predisposed to breast cancer due to BRCA1 or BRCA2 germ-line mutations. Accumulation of somatic genetic changes during tumor progression may follow a specific and more aggressive pathway of chromosome damage in these individuals. Although the sequence of molecular events in the progression of breast tumor is poorly understood the detected genetic alterations fit the model of multistep carcinogenesis in both sporadic and hereditary breast cancer. This review will focus on the genetic lesions within the breast cancer cell.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B6WWY-45FJYBT-11/2/17e53bbb32a0715e9f036962a9f199f1

Full metadata record

DC FieldValue Language
dc.contributor.authorIngvarsson, S-
dc.date.accessioned2009-01-06T14:49:31Z-
dc.date.available2009-01-06T14:49:31Z-
dc.date.issued1999-08-01-
dc.date.submitted2008-01-06-
dc.identifier.citationSemin. Cancer Biol. 1999, 9(4):277-88en
dc.identifier.issn1044-579X-
dc.identifier.pmid10448115-
dc.identifier.doi10.1006/scbi.1999.0124-
dc.identifier.urihttp://hdl.handle.net/2336/47082-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractSomatic changes in the genome of breast cancer cells include amplifications, deletions and gene mutations. Several chromosome regions harboring known oncogenes are found amplified in breast tumors. Despite the high number of chromosome regions deleted in breast tumors the functional relationship to known genes at these locations and cancer growth is mainly undiscovered. Mutations in two tumor suppressor genes (TSG) have been described in a subset of breast carcinomas. These TSG are the TP53, encoding the p53 transcription factor, and the CDH1, encoding the cadherin cell adhesion molecule. Breast tumors of patients with a germ-line mutation in the BRCA1 or BRCA2 gene have an increase of additional genetic defects compared with sporadic breast tumors. This higher frequency of genetic aberrations could pinpoint genes that selectively promote tumor progression in individuals predisposed to breast cancer due to BRCA1 or BRCA2 germ-line mutations. Accumulation of somatic genetic changes during tumor progression may follow a specific and more aggressive pathway of chromosome damage in these individuals. Although the sequence of molecular events in the progression of breast tumor is poorly understood the detected genetic alterations fit the model of multistep carcinogenesis in both sporadic and hereditary breast cancer. This review will focus on the genetic lesions within the breast cancer cell.en
dc.language.isoenen
dc.publisherAcademic Pressen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6WWY-45FJYBT-11/2/17e53bbb32a0715e9f036962a9f199f1en
dc.subject.meshBreast Neoplasmsen
dc.subject.meshCarcinoma in Situen
dc.subject.meshDNA Replicationen
dc.subject.meshDisease Progressionen
dc.subject.meshGene Amplificationen
dc.subject.meshGerm-Line Mutationen
dc.subject.meshHumansen
dc.subject.meshMutationen
dc.subject.meshPrecancerous Conditionsen
dc.subject.meshPrognosisen
dc.titleMolecular genetics of breast cancer progressionen
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, University Hospital of Iceland, Reykjavik, Iceland.en
dc.identifier.journalSeminars in cancer biologyen

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