Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome

2.50
Hdl Handle:
http://hdl.handle.net/2336/47294
Title:
Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome
Authors:
Gislason, Thorarinn; Johannsson, Johann Heidar; Haraldsson, Asgeir; Olafsdottir, Berglind Ran; Jonsdottir, Helga; Kong, Augustine; Frigge, Michael L; Jonsdottir, Guthrun M; Hakonarson, Hakon; Gulcher, Jeffrey; Stefansson, Kari
Citation:
Am. J. Respir. Crit. Care Med. 2002, 166(6):833-8
Issue Date:
15-Sep-2002
Abstract:
Previous studies suggest a familial link between adult obstructive sleep apnea syndrome (OSAS) and sudden infant death syndrome (SIDS). However, most of these studies were hampered by the availability of too few cases of SIDS to draw conclusions. To examine the familial nature of this association in Iceland, hospital-based lists of all patients who were diagnosed with OSAS (n = 2,350) and SIDS (n = 58) from 1979 to 1998 were used to separately determine the familial occurrence of OSAS and SIDS and to search for evidence of cosegregation of these conditions in Icelandic families, using a nationwide genealogy database. The risk ratio for a first-degree relative of a patient with OSAS was 2.0 (1.7-2.8, 95% confidence interval). The risk ratio of the more severely affected patients with OSAS was slightly higher (2.3). Likewise, the kinship coefficient (KC) for the OSAS patient group, which determines the relatedness of the patients, was significantly larger than the mean KC of 1,000 matched control groups. Estimation of the KC for the SIDS group showed a trend toward significance when compared with control groups, but after excluding one of the half-siblings in the SIDS group from the analysis, the difference did not show any trend toward significance. Although the results of the analysis of the relatedness between all patients with OSAS and infants who died of SIDS were not significant, a trend toward significance was evident when the data were separately analyzed for the more severely affected patients with OSAS. Collectively, these results demonstrate a strong familial component in OSAS and suggest that infants who died of SIDS may have shared some of the same susceptibility factors with OSAS.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://ajrccm.atsjournals.org/cgi/content/abstract/166/6/833

Full metadata record

DC FieldValue Language
dc.contributor.authorGislason, Thorarinn-
dc.contributor.authorJohannsson, Johann Heidar-
dc.contributor.authorHaraldsson, Asgeir-
dc.contributor.authorOlafsdottir, Berglind Ran-
dc.contributor.authorJonsdottir, Helga-
dc.contributor.authorKong, Augustine-
dc.contributor.authorFrigge, Michael L-
dc.contributor.authorJonsdottir, Guthrun M-
dc.contributor.authorHakonarson, Hakon-
dc.contributor.authorGulcher, Jeffrey-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2009-01-12T09:47:05Z-
dc.date.available2009-01-12T09:47:05Z-
dc.date.issued2002-09-15-
dc.date.submitted2009-01-12-
dc.identifier.citationAm. J. Respir. Crit. Care Med. 2002, 166(6):833-8en
dc.identifier.issn1073-449X-
dc.identifier.issn1535-4970-
dc.identifier.pmid12231493-
dc.identifier.doi10.1164/rccm.2107121-
dc.identifier.urihttp://hdl.handle.net/2336/47294-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPrevious studies suggest a familial link between adult obstructive sleep apnea syndrome (OSAS) and sudden infant death syndrome (SIDS). However, most of these studies were hampered by the availability of too few cases of SIDS to draw conclusions. To examine the familial nature of this association in Iceland, hospital-based lists of all patients who were diagnosed with OSAS (n = 2,350) and SIDS (n = 58) from 1979 to 1998 were used to separately determine the familial occurrence of OSAS and SIDS and to search for evidence of cosegregation of these conditions in Icelandic families, using a nationwide genealogy database. The risk ratio for a first-degree relative of a patient with OSAS was 2.0 (1.7-2.8, 95% confidence interval). The risk ratio of the more severely affected patients with OSAS was slightly higher (2.3). Likewise, the kinship coefficient (KC) for the OSAS patient group, which determines the relatedness of the patients, was significantly larger than the mean KC of 1,000 matched control groups. Estimation of the KC for the SIDS group showed a trend toward significance when compared with control groups, but after excluding one of the half-siblings in the SIDS group from the analysis, the difference did not show any trend toward significance. Although the results of the analysis of the relatedness between all patients with OSAS and infants who died of SIDS were not significant, a trend toward significance was evident when the data were separately analyzed for the more severely affected patients with OSAS. Collectively, these results demonstrate a strong familial component in OSAS and suggest that infants who died of SIDS may have shared some of the same susceptibility factors with OSAS.en
dc.language.isoenen
dc.publisherAmerican Thoracic Societyen
dc.relation.urlhttp://ajrccm.atsjournals.org/cgi/content/abstract/166/6/833en
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAge Factorsen
dc.subject.meshAgeden
dc.subject.meshCluster Analysisen
dc.subject.meshConfidence Intervalsen
dc.subject.meshDatabases, Factualen
dc.subject.meshFemaleen
dc.subject.meshGenealogy and Heraldryen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshIcelanden
dc.subject.meshInfanten
dc.subject.meshInfant, Newbornen
dc.subject.meshLife Styleen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshOdds Ratioen
dc.subject.meshPositive-Pressure Respirationen
dc.subject.meshRisken
dc.subject.meshSex Factorsen
dc.subject.meshSleep Apnea, Obstructiveen
dc.subject.meshSudden Infant Deathen
dc.subject.meshSyndromeen
dc.titleFamilial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndromeen
dc.typeArticleen
dc.contributor.departmentDepartment of Pulmonary Medicine, Vífilsstadir, Gardabaer, Iceland. thorarig@rsp.isen
dc.identifier.journalAmerican journal of respiratory and critical care medicineen

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