TT virus infections among blood donors in Iceland: prevalence, genotypes, and lack of relationship to serum ALT levels.

2.50
Hdl Handle:
http://hdl.handle.net/2336/47297
Title:
TT virus infections among blood donors in Iceland: prevalence, genotypes, and lack of relationship to serum ALT levels.
Authors:
Löve, A; Stanzeit, B; Li, L; Olafsdottir, E; Gudmundsson, S; Briem, H; Widell, A
Citation:
Transfusion. 2000, 40(3):306-9
Issue Date:
1-Mar-2000
Abstract:
BACKGROUND: The TT virus (TTV) is a newly identified blood-borne virus. Its association with disease is still unknown, and screening of blood donors has not been implemented. Several genotypes of the TTV have been identified. STUDY DESIGN AND METHODS: Three hundred seventy healthy blood donors were randomly selected and tested for TTV by the PCR method. Sequencing of a part of the genome was performed to identify various genotypes of the virus. ALT levels were determined in both infected and uninfected individuals. RESULTS: The TT virus (TTV), was detected in the sera of 23 (6.2%) of 370 healthy Icelandic blood donors; this prevalence is lower than that reported in Japan but higher than that in Scotland. The virus was found in all groups over the age of 19. Sequencing and phylogenetic analysis of 202 bp from open reading frame 1 demonstrated genotypes 1b and 2b 2c and genotype 4 isolates, with the latter bearing 89-percent nucleotide homology with other genotype 4 sequences deposited at GenBank. One sample showed a mixed genotype 1b/2c infection. Serum ALT levels were within normal limits in all infected individuals. CONCLUSION: The TTV carrier state does not cause significant liver injury.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1046/j.1537-2995.2000.40030306.x

Full metadata record

DC FieldValue Language
dc.contributor.authorLöve, A-
dc.contributor.authorStanzeit, B-
dc.contributor.authorLi, L-
dc.contributor.authorOlafsdottir, E-
dc.contributor.authorGudmundsson, S-
dc.contributor.authorBriem, H-
dc.contributor.authorWidell, A-
dc.date.accessioned2009-01-12T11:19:22Z-
dc.date.available2009-01-12T11:19:22Z-
dc.date.issued2000-03-01-
dc.date.submitted2009-01-12-
dc.identifier.citationTransfusion. 2000, 40(3):306-9en
dc.identifier.issn0041-1132-
dc.identifier.pmid10738031-
dc.identifier.doi10.1046/j.1537-2995.2000.40030306.x-
dc.identifier.urihttp://hdl.handle.net/2336/47297-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: The TT virus (TTV) is a newly identified blood-borne virus. Its association with disease is still unknown, and screening of blood donors has not been implemented. Several genotypes of the TTV have been identified. STUDY DESIGN AND METHODS: Three hundred seventy healthy blood donors were randomly selected and tested for TTV by the PCR method. Sequencing of a part of the genome was performed to identify various genotypes of the virus. ALT levels were determined in both infected and uninfected individuals. RESULTS: The TT virus (TTV), was detected in the sera of 23 (6.2%) of 370 healthy Icelandic blood donors; this prevalence is lower than that reported in Japan but higher than that in Scotland. The virus was found in all groups over the age of 19. Sequencing and phylogenetic analysis of 202 bp from open reading frame 1 demonstrated genotypes 1b and 2b 2c and genotype 4 isolates, with the latter bearing 89-percent nucleotide homology with other genotype 4 sequences deposited at GenBank. One sample showed a mixed genotype 1b/2c infection. Serum ALT levels were within normal limits in all infected individuals. CONCLUSION: The TTV carrier state does not cause significant liver injury.en
dc.language.isoenen
dc.publisherAmerican Association Of Blood Banksen
dc.relation.urlhttp://dx.doi.org/10.1046/j.1537-2995.2000.40030306.xen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAlanine Transaminaseen
dc.subject.meshBlood Donorsen
dc.subject.meshChilden
dc.subject.meshDNA Virus Infectionsen
dc.subject.meshDNA Virusesen
dc.subject.meshFemaleen
dc.subject.meshGenotypeen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPrevalenceen
dc.titleTT virus infections among blood donors in Iceland: prevalence, genotypes, and lack of relationship to serum ALT levels.en
dc.typeArticleen
dc.contributor.departmentBlood Bank and the Departments of Medical Virology and Clinical Biochemistry, National University Hospital, Reykjavik, Iceland. arthur@rsp.isen
dc.identifier.journalTransfusionen

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