Decreased respiratory depression during emergence from anesthesia with sevoflurane/N2O than with sevoflurane alone

2.50
Hdl Handle:
http://hdl.handle.net/2336/47360
Title:
Decreased respiratory depression during emergence from anesthesia with sevoflurane/N2O than with sevoflurane alone
Authors:
Einarsson, S; Bengtsson, A; Stenqvist, O; Bengtson, J P
Citation:
Can J Anaesth. 1999, 46(4):335-41
Issue Date:
1-Apr-1999
Abstract:
PURPOSE: To investigate ventilation and gas elimination during the emergence from inhalational anesthesia with controlled normoventilation with either sevoflurane/N2O or sevoflurane alone. METHODS: Twenty-four ASA I-II patients scheduled for abdominal hysterectomy were randomly allocated to receive either 1.3 MAC sevoflurane/N2O (n = 12) or equi-MAC sevoflurane (n = 12) in 30% oxygen (O2). Expired minute ventilation volumes (V(E)), end-tidal (ET) concentrations of O2, carbon dioxide (CO2), sevoflurane and N2O as well as pulse oximetry saturation (SpO2) and CO2 elimination rates (VCO2) were measured. The ET concentrations of sevoflurane and N2O were converted to total MAC values and gas elimination was expressed in terms of MAC reduction. Time to resumption of spontaneous breathing and extubation were recorded and arterial blood gas analysis was performed at the end of controlled normoventilation and at the beginning of spontaneous breathing. RESULTS: Resumption of spontaneous breathing and extubation were 8 and 13 min less, respectively, in the sevoflurane/N2O than in the sevoflurane group. Spontaneous breathing was resumed in both groups when pH had decreased by 0.07-0.08 and PaCO2 increased by 1.3-1.5 kPa. Depression of V(E) and VCO2 were less, and MAC reduction more rapid in the sevoflurane/N2O than in the sevoflurane group. CONCLUSIONS: Respiratory recovery was faster after sevoflurane/N2O than sevoflurane anesthesia. Changes in pH and PaCO2 rather than absolute values were important for resumption of spontaneous breathing after controlled normoventilation. In both groups, the tracheas were extubated at about 0.2 MAC.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.cja-jca.org/cgi/content/abstract/46/4/335

Full metadata record

DC FieldValue Language
dc.contributor.authorEinarsson, S-
dc.contributor.authorBengtsson, A-
dc.contributor.authorStenqvist, O-
dc.contributor.authorBengtson, J P-
dc.date.accessioned2009-01-13T14:00:12Z-
dc.date.available2009-01-13T14:00:12Z-
dc.date.issued1999-04-01-
dc.date.submitted2009-01-13-
dc.identifier.citationCan J Anaesth. 1999, 46(4):335-41en
dc.identifier.issn0832-610X-
dc.identifier.pmid10232716-
dc.identifier.urihttp://hdl.handle.net/2336/47360-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPURPOSE: To investigate ventilation and gas elimination during the emergence from inhalational anesthesia with controlled normoventilation with either sevoflurane/N2O or sevoflurane alone. METHODS: Twenty-four ASA I-II patients scheduled for abdominal hysterectomy were randomly allocated to receive either 1.3 MAC sevoflurane/N2O (n = 12) or equi-MAC sevoflurane (n = 12) in 30% oxygen (O2). Expired minute ventilation volumes (V(E)), end-tidal (ET) concentrations of O2, carbon dioxide (CO2), sevoflurane and N2O as well as pulse oximetry saturation (SpO2) and CO2 elimination rates (VCO2) were measured. The ET concentrations of sevoflurane and N2O were converted to total MAC values and gas elimination was expressed in terms of MAC reduction. Time to resumption of spontaneous breathing and extubation were recorded and arterial blood gas analysis was performed at the end of controlled normoventilation and at the beginning of spontaneous breathing. RESULTS: Resumption of spontaneous breathing and extubation were 8 and 13 min less, respectively, in the sevoflurane/N2O than in the sevoflurane group. Spontaneous breathing was resumed in both groups when pH had decreased by 0.07-0.08 and PaCO2 increased by 1.3-1.5 kPa. Depression of V(E) and VCO2 were less, and MAC reduction more rapid in the sevoflurane/N2O than in the sevoflurane group. CONCLUSIONS: Respiratory recovery was faster after sevoflurane/N2O than sevoflurane anesthesia. Changes in pH and PaCO2 rather than absolute values were important for resumption of spontaneous breathing after controlled normoventilation. In both groups, the tracheas were extubated at about 0.2 MAC.en
dc.language.isoenen
dc.publisherCanadian Anaesthetists' Societyen
dc.relation.urlhttp://www.cja-jca.org/cgi/content/abstract/46/4/335en
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAnesthesia Recovery Perioden
dc.subject.meshAnesthetics, Inhalationen
dc.subject.meshCarbon Dioxideen
dc.subject.meshFemaleen
dc.subject.meshHydrogen-Ion Concentrationen
dc.subject.meshHysterectomyen
dc.subject.meshIntubation, Intratrachealen
dc.subject.meshMaximal Voluntary Ventilationen
dc.subject.meshMethyl Ethersen
dc.subject.meshMiddle Ageden
dc.subject.meshNitrous Oxideen
dc.subject.meshOxygenen
dc.subject.meshPulmonary Gas Exchangeen
dc.subject.meshRespirationen
dc.subject.meshTidal Volumeen
dc.subject.meshTime Factorsen
dc.titleDecreased respiratory depression during emergence from anesthesia with sevoflurane/N2O than with sevoflurane aloneen
dc.typeArticleen
dc.contributor.departmentDepartment of Anesthesia and Intensive Care, Reykjavik Hospital (University Teaching Hospital), Iceland. sveinng@shr.isen
dc.identifier.journalCanadian journal of anaesthesia = Journal canadien d'anesthésieen

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