Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival.

2.50
Hdl Handle:
http://hdl.handle.net/2336/47454
Title:
Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival.
Authors:
Ragnarsson, G; Eiriksdottir, G; Johannsdottir, J T; Jonasson, J G; Egilsson, V; Ingvarsson, S
Citation:
Br. J. Cancer. 1999, 79(9-10):1468-74
Issue Date:
1-Mar-1999
Abstract:
The distal half of chromosome 1p was analysed with 15 polymorphic microsatellite markers in 683 human solid tumours at different locations. Loss of heterozygosity (LOH) was observed at least at one site in 369 cases or 54% of the tumours. LOHs detected ranged from 30-64%, depending on tumour location. The major results regarding LOH at different tumour locations were as follows: stomach, 20/38 (53%); colon and rectum, 60/109 (55%); lung, 38/63 (60%); breast, 145/238 (61%); endometrium, 18/25 (72%); ovary, 17/31 (55%); testis, 11/30 (37%); kidney, 22/73 (30%); thyroid, 4/14 (29%); and sarcomas, 9/14 (64%). High percentages of LOH were seen in the 1p36.3, 1p36.1, 1p35-p34.3, 1p32 and 1p31 regions, suggesting the presence of tumour-suppressor genes. All these regions on chromosome 1p show high LOH in more than one tumour type. However, distinct patterns of LOH were detected at different tumour locations. There was a significant separation of survival curves, with and without LOH at chromosome 1p, in the breast cancer patients. Multivariate analysis showed that LOH at 1p in breast tumours is a better indicator for prognosis than the other variables tested in our model, including nodal metastasis.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/sj.bjc.6690234

Full metadata record

DC FieldValue Language
dc.contributor.authorRagnarsson, G-
dc.contributor.authorEiriksdottir, G-
dc.contributor.authorJohannsdottir, J T-
dc.contributor.authorJonasson, J G-
dc.contributor.authorEgilsson, V-
dc.contributor.authorIngvarsson, S-
dc.date.accessioned2009-01-15T10:10:59Z-
dc.date.available2009-01-15T10:10:59Z-
dc.date.issued1999-03-01-
dc.date.submitted2009-01-15-
dc.identifier.citationBr. J. Cancer. 1999, 79(9-10):1468-74en
dc.identifier.issn0007-0920-
dc.identifier.pmid10188892-
dc.identifier.doi10.1038/sj.bjc.6690234-
dc.identifier.urihttp://hdl.handle.net/2336/47454-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThe distal half of chromosome 1p was analysed with 15 polymorphic microsatellite markers in 683 human solid tumours at different locations. Loss of heterozygosity (LOH) was observed at least at one site in 369 cases or 54% of the tumours. LOHs detected ranged from 30-64%, depending on tumour location. The major results regarding LOH at different tumour locations were as follows: stomach, 20/38 (53%); colon and rectum, 60/109 (55%); lung, 38/63 (60%); breast, 145/238 (61%); endometrium, 18/25 (72%); ovary, 17/31 (55%); testis, 11/30 (37%); kidney, 22/73 (30%); thyroid, 4/14 (29%); and sarcomas, 9/14 (64%). High percentages of LOH were seen in the 1p36.3, 1p36.1, 1p35-p34.3, 1p32 and 1p31 regions, suggesting the presence of tumour-suppressor genes. All these regions on chromosome 1p show high LOH in more than one tumour type. However, distinct patterns of LOH were detected at different tumour locations. There was a significant separation of survival curves, with and without LOH at chromosome 1p, in the breast cancer patients. Multivariate analysis showed that LOH at 1p in breast tumours is a better indicator for prognosis than the other variables tested in our model, including nodal metastasis.en
dc.language.isoenen
dc.publisherNature Publishing Group on behalf of Cancer Research UKen
dc.relation.urlhttp://dx.doi.org/10.1038/sj.bjc.6690234en
dc.subject.meshAnalysis of Varianceen
dc.subject.meshChi-Square Distributionen
dc.subject.meshChromosome Mappingen
dc.subject.meshChromosomes, Human, Pair 1en
dc.subject.meshFemaleen
dc.subject.meshGenetic Markersen
dc.subject.meshHumansen
dc.subject.meshLoss of Heterozygosityen
dc.subject.meshMaleen
dc.subject.meshMicrosatellite Repeatsen
dc.subject.meshNeoplasmsen
dc.subject.meshSurvival Analysisen
dc.titleLoss of heterozygosity at chromosome 1p in different solid human tumours: association with survival.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, University and National Hospital of Iceland, Reykjavik.en
dc.identifier.journalBritish journal of canceren

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