Corticotropin-induced reduction of plasma lipoprotein(a) concentrations in healthy individuals and hemodialysis patients: relation to apolipoprotein(a) size polymorphism

2.50
Hdl Handle:
http://hdl.handle.net/2336/47465
Title:
Corticotropin-induced reduction of plasma lipoprotein(a) concentrations in healthy individuals and hemodialysis patients: relation to apolipoprotein(a) size polymorphism
Authors:
Arnadottir, M; Berg, A L; Kronenberg, F; Lingenhel, A; Hugosson, T; Hegbrant, J; Nilsson-Ehle, P
Citation:
Metab. Clin. Exp. 1999, 48(3):342-6
Issue Date:
1-Mar-1999
Abstract:
Lipoprotein(a) [Lp(a)], a strong independent cardiovascular risk factor, consists of the unique apolipoprotein(a) [apo(a)] covalently linked to a low-density lipoprotein particle. Apo(a) contains a widely differing number of the plasminogen-like kringle IV, a size polymorphism that is codominantly inherited. In addition to powerful genetic control, renal failure is known to influence the plasma Lp(a) concentration. There is still a lot to be learned about the mode and site of catabolism of Lp(a), and there is no readily applicable Lp(a)-lowering treatment available. Therefore, it was of interest to study further the Lp(a)-lowering effect of corticotropin (ACTH) that has been demonstrated in small studies. The main purpose of the present study was to investigate the influence of ACTH on different apo(a) isoforms. Short-term treatment with ACTH decreased the plasma Lp(a) concentration in all 26 study participants. The two study groups (12 healthy individuals and 14 hemodialysis patients) responded similarly, with a median decrease in plasma Lp(a) of 39% and 49%, respectively. In subjects with two clearly separable apo(a) bands, apo(a) phenotyping and densitometric scanning of the bands before and after treatment with ACTH revealed a change in the proportion of apo(a) isoforms, ie, a shift toward the isoform with lower molecular weight. This was observed in seven of nine investigated subjects (four of five healthy individuals and three of four hemodialysis patients).
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B6WN4-4D6XM6M-FX/2/df90d15d55e903cc0834bdcf052ce827

Full metadata record

DC FieldValue Language
dc.contributor.authorArnadottir, M-
dc.contributor.authorBerg, A L-
dc.contributor.authorKronenberg, F-
dc.contributor.authorLingenhel, A-
dc.contributor.authorHugosson, T-
dc.contributor.authorHegbrant, J-
dc.contributor.authorNilsson-Ehle, P-
dc.date.accessioned2009-01-15T11:25:39Z-
dc.date.available2009-01-15T11:25:39Z-
dc.date.issued1999-03-01-
dc.date.submitted2009-01-15-
dc.identifier.citationMetab. Clin. Exp. 1999, 48(3):342-6en
dc.identifier.issn0026-0495-
dc.identifier.pmid10094111-
dc.identifier.doi10.1016/S0026-0495(99)90083-5-
dc.identifier.urihttp://hdl.handle.net/2336/47465-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractLipoprotein(a) [Lp(a)], a strong independent cardiovascular risk factor, consists of the unique apolipoprotein(a) [apo(a)] covalently linked to a low-density lipoprotein particle. Apo(a) contains a widely differing number of the plasminogen-like kringle IV, a size polymorphism that is codominantly inherited. In addition to powerful genetic control, renal failure is known to influence the plasma Lp(a) concentration. There is still a lot to be learned about the mode and site of catabolism of Lp(a), and there is no readily applicable Lp(a)-lowering treatment available. Therefore, it was of interest to study further the Lp(a)-lowering effect of corticotropin (ACTH) that has been demonstrated in small studies. The main purpose of the present study was to investigate the influence of ACTH on different apo(a) isoforms. Short-term treatment with ACTH decreased the plasma Lp(a) concentration in all 26 study participants. The two study groups (12 healthy individuals and 14 hemodialysis patients) responded similarly, with a median decrease in plasma Lp(a) of 39% and 49%, respectively. In subjects with two clearly separable apo(a) bands, apo(a) phenotyping and densitometric scanning of the bands before and after treatment with ACTH revealed a change in the proportion of apo(a) isoforms, ie, a shift toward the isoform with lower molecular weight. This was observed in seven of nine investigated subjects (four of five healthy individuals and three of four hemodialysis patients).en
dc.language.isoenen
dc.publisherW.B. Saundersen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6WN4-4D6XM6M-FX/2/df90d15d55e903cc0834bdcf052ce827en
dc.subject.meshAdrenocorticotropic Hormoneen
dc.subject.meshAdulten
dc.subject.meshApolipoproteins Aen
dc.subject.meshElectrophoresis, Polyacrylamide Gelen
dc.subject.meshGenotypeen
dc.subject.meshHumansen
dc.subject.meshKidney Failure, Chronicen
dc.subject.meshKringlesen
dc.subject.meshLipoprotein(a)en
dc.subject.meshLiver Function Testsen
dc.subject.meshMaleen
dc.subject.meshMolecular Weighten
dc.subject.meshPhenotypeen
dc.subject.meshPolymorphism, Geneticen
dc.subject.meshRenal Dialysisen
dc.titleCorticotropin-induced reduction of plasma lipoprotein(a) concentrations in healthy individuals and hemodialysis patients: relation to apolipoprotein(a) size polymorphismen
dc.typeArticleen
dc.contributor.departmentDepartment of Medicine, National University Hospital, Reykjavik, Iceland.en
dc.identifier.journalMetabolism: clinical and experimentalen

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