A study of the association of HLA DR, DQ, and complement C4 alleles with systemic lupus erythematosus in Iceland

2.50
Hdl Handle:
http://hdl.handle.net/2336/47808
Title:
A study of the association of HLA DR, DQ, and complement C4 alleles with systemic lupus erythematosus in Iceland
Authors:
Steinsson, K; Jonsdottir, S; Arason, G J; Kristjansdottir, H; Fossdal, R; Skaftadottir, I; Arnason, A
Citation:
Ann. Rheum. Dis. 1998, 57(8):503-5
Issue Date:
1-Aug-1998
Abstract:
OBJECTIVE: To perform an exploratory analysis of the relative contribution of single MHC genes to the pathogenesis of systemic lupus erythematosus (SLE) in a homogenous white population. METHODS: MHC class II alleles and C4 allotypes were determined in 64 SLE patients and in ethnically matched controls. HLA-DR and DQ typing was performed by polymerase chain reaction amplification with sequence specific primers. C4 allotypes were determined by agarose gel electrophoresis. RESULTS: The frequency of C4A*Q0 was significantly higher in patients than in controls (46.9% v 25.3%, p = 0.002). HLA-DRB1, DQA1, and DQB1 alleles in the whole group of SLE patients were not significantly different from those of controls. On the other hand increase in DRB1*03 was observed in the group of patients with C4A*Q0, as compared with patients with other C4A allotypes (p = 0.047). There was no significant correlation between severe and mild disease, as judged by the SLEDAI, and HLADR, DQ alleles and comparing the patients with C4A*Q0 with those with other C4A allotypes there was no significant difference regarding clinical manifestations. CONCLUSION: The results are consistent with the argument that C4A deficiency contributes independently to susceptibility and the pathogenesis of SLE. C4A*Q0 in SLE patients in Iceland shows weaker linkage disequilibrium with DR3 genes than reported in most other white populations and emphasises the role of ethnicity.
Description:
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Additional Links:
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Full metadata record

DC FieldValue Language
dc.contributor.authorSteinsson, K-
dc.contributor.authorJonsdottir, S-
dc.contributor.authorArason, G J-
dc.contributor.authorKristjansdottir, H-
dc.contributor.authorFossdal, R-
dc.contributor.authorSkaftadottir, I-
dc.contributor.authorArnason, A-
dc.date.accessioned2009-01-21T15:20:30Z-
dc.date.available2009-01-21T15:20:30Z-
dc.date.issued1998-08-01-
dc.date.submitted2009-01-21-
dc.identifier.citationAnn. Rheum. Dis. 1998, 57(8):503-5en
dc.identifier.issn0003-4967-
dc.identifier.pmid9797559-
dc.identifier.doi10.1136/ard.57.8.503-
dc.identifier.urihttp://hdl.handle.net/2336/47808-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: To perform an exploratory analysis of the relative contribution of single MHC genes to the pathogenesis of systemic lupus erythematosus (SLE) in a homogenous white population. METHODS: MHC class II alleles and C4 allotypes were determined in 64 SLE patients and in ethnically matched controls. HLA-DR and DQ typing was performed by polymerase chain reaction amplification with sequence specific primers. C4 allotypes were determined by agarose gel electrophoresis. RESULTS: The frequency of C4A*Q0 was significantly higher in patients than in controls (46.9% v 25.3%, p = 0.002). HLA-DRB1, DQA1, and DQB1 alleles in the whole group of SLE patients were not significantly different from those of controls. On the other hand increase in DRB1*03 was observed in the group of patients with C4A*Q0, as compared with patients with other C4A allotypes (p = 0.047). There was no significant correlation between severe and mild disease, as judged by the SLEDAI, and HLADR, DQ alleles and comparing the patients with C4A*Q0 with those with other C4A allotypes there was no significant difference regarding clinical manifestations. CONCLUSION: The results are consistent with the argument that C4A deficiency contributes independently to susceptibility and the pathogenesis of SLE. C4A*Q0 in SLE patients in Iceland shows weaker linkage disequilibrium with DR3 genes than reported in most other white populations and emphasises the role of ethnicity.en
dc.language.isoenen
dc.publisherLæknafélag Íslands, Læknafélag Reykjavíkuren
dc.relation.urlhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9797559en
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAllelesen
dc.subject.meshChilden
dc.subject.meshComplement C4en
dc.subject.meshFemaleen
dc.subject.meshGenes, MHC Class IIen
dc.subject.meshHLA-DQ Antigensen
dc.subject.meshHLA-DR Antigensen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshLupus Erythematosus, Systemicen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.titleA study of the association of HLA DR, DQ, and complement C4 alleles with systemic lupus erythematosus in Icelanden
dc.typeArticleen
dc.contributor.departmentDepartment of Internal Medicine, Landspítalinn, National University Hospital, Reykjavik, Iceland.en
dc.identifier.journalAnnals of the rheumatic diseasesen
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