High incidence of loss of heterozygosity in breast tumors from carriers of the BRCA2 999del5 mutation

2.50
Hdl Handle:
http://hdl.handle.net/2336/47994
Title:
High incidence of loss of heterozygosity in breast tumors from carriers of the BRCA2 999del5 mutation
Authors:
Ingvarsson, S; Geirsdottir, E K; Johannesdottir, G; Sigbjornsdottir, B I; Eiriksdottir, G; Ragnarsson, G; Agnarsson, B A; Gudmundsson, J; Jonasson, J G; Sigurdsson, A; Egilsson, V; Barkardottir, R B
Citation:
Cancer Res. 1998, 58(19):4421-5
Issue Date:
1-Oct-1998
Abstract:
Germ-line mutation in the BRCA2 gene confers an increased risk of breast cancer. An elevation of additional genetic defects in tumors of patients with germ-line mutation in the BRCA2 gene compared with sporadic breast tumors has been reported. To evaluate the nature of the difference, we did detailed mapping of chromosomes 1p, 3p, 6q, 11, 13q, 16q, 17, and 20q, using microsatellite markers. We found that the frequency of loss of heterozygosity was similar at some chromosomal regions in the BRCA2 999del5 and sporadic tumors but significantly different at others. These others include chromosomal arms 3p, 6q, 11p, 11q, 13q, and 17p. Loss of heterozygosity mapping suggests that the same chromosome regions are involved in both tumor groups but at elevated frequencies in BRCA2 999del5 tumors. This higher frequency of genetic aberrations could pinpoint genes that selectively promote tumor progression in individuals predisposed to breast cancer due to the BRCA2 999del5 germ-line mutation. Accumulation of somatic genetic changes during tumor progression may follow a specific and more aggressive pathway of chromosome damage in these individuals.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://cancerres.aacrjournals.org/cgi/content/abstract/58/19/4421

Full metadata record

DC FieldValue Language
dc.contributor.authorIngvarsson, S-
dc.contributor.authorGeirsdottir, E K-
dc.contributor.authorJohannesdottir, G-
dc.contributor.authorSigbjornsdottir, B I-
dc.contributor.authorEiriksdottir, G-
dc.contributor.authorRagnarsson, G-
dc.contributor.authorAgnarsson, B A-
dc.contributor.authorGudmundsson, J-
dc.contributor.authorJonasson, J G-
dc.contributor.authorSigurdsson, A-
dc.contributor.authorEgilsson, V-
dc.contributor.authorBarkardottir, R B-
dc.date.accessioned2009-01-26T09:58:31Z-
dc.date.available2009-01-26T09:58:31Z-
dc.date.issued1998-10-01-
dc.date.submitted2009-01-26-
dc.identifier.citationCancer Res. 1998, 58(19):4421-5en
dc.identifier.issn0008-5472-
dc.identifier.pmid9766673-
dc.identifier.urihttp://hdl.handle.net/2336/47994-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractGerm-line mutation in the BRCA2 gene confers an increased risk of breast cancer. An elevation of additional genetic defects in tumors of patients with germ-line mutation in the BRCA2 gene compared with sporadic breast tumors has been reported. To evaluate the nature of the difference, we did detailed mapping of chromosomes 1p, 3p, 6q, 11, 13q, 16q, 17, and 20q, using microsatellite markers. We found that the frequency of loss of heterozygosity was similar at some chromosomal regions in the BRCA2 999del5 and sporadic tumors but significantly different at others. These others include chromosomal arms 3p, 6q, 11p, 11q, 13q, and 17p. Loss of heterozygosity mapping suggests that the same chromosome regions are involved in both tumor groups but at elevated frequencies in BRCA2 999del5 tumors. This higher frequency of genetic aberrations could pinpoint genes that selectively promote tumor progression in individuals predisposed to breast cancer due to the BRCA2 999del5 germ-line mutation. Accumulation of somatic genetic changes during tumor progression may follow a specific and more aggressive pathway of chromosome damage in these individuals.en
dc.language.isoenen
dc.publisherAmerican Association for Cancer Researchen
dc.relation.urlhttp://cancerres.aacrjournals.org/cgi/content/abstract/58/19/4421en
dc.subject.meshBRCA2 Proteinen
dc.subject.meshBreast Neoplasmsen
dc.subject.meshChromosome Mappingen
dc.subject.meshChromosomes, Humanen
dc.subject.meshFemaleen
dc.subject.meshGenetic Markersen
dc.subject.meshHeterozygoteen
dc.subject.meshHeterozygote Detectionen
dc.subject.meshHumansen
dc.subject.meshLoss of Heterozygosityen
dc.subject.meshMicrosatellite Repeatsen
dc.subject.meshNeoplasm Proteinsen
dc.subject.meshSequence Deletionen
dc.subject.meshTranscription Factorsen
dc.titleHigh incidence of loss of heterozygosity in breast tumors from carriers of the BRCA2 999del5 mutationen
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, University Hospital of Iceland, Reykjavik.en
dc.identifier.journalCancer researchen

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