Copper, ceruloplasmin and superoxide dismutase in patients with Alzheimer's disease . a case-control study

2.50
Hdl Handle:
http://hdl.handle.net/2336/48001
Title:
Copper, ceruloplasmin and superoxide dismutase in patients with Alzheimer's disease . a case-control study
Authors:
Snaedal, J; Kristinsson, J; Gunnarsdottir, S; Olafsdottir; Baldvinsson, M; Johannesson, T
Citation:
Dement Geriatr Cogn Disord. 1998, 9(5):239-42
Issue Date:
Oct-1998
Abstract:
The copper-containing enzyme superoxide dismutase (SOD) is a key enzyme in suppressing the amounts of superoxide anion radicals. Ceruloplasmin, the copper-transporting protein in plasma, also possesses an important redox capacity. In this study the levels of copper and ceruloplasmin as well as SOD-activity and ceruloplasmin oxidative activity were analyzed in order to throw some light on possible defects in copper mechanisms in patients diagnosed with Alzheimer's disease (AD). The study included 44 patients with AD and their healthy age- and gender-matched controls. No difference of significance was seen when comparing the copper or ceruloplasmin concentration in plasma of AD patients to that of their paired controls. The SOD activity in red blood cells was significantly lower in the patients than in their controls (p = 0.019). The ceruloplasmin oxidative activity in plasma of Alzheimer's patients was greatly reduced as compared to that of age- and gender-matched controls and the difference was highly significant (p = 0.0005). Ceruloplasmin activity and SOD activity were not found to be intrinsically correlated. It was postulated that reduced oxidative activity of ceruloplasmin in plasma might be either a cause or a consequence of AD and that reduced SOD activity might further add to the oxidative disturbances in AD due to defective ceruloplasmin activity.
Description:
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Full metadata record

DC FieldValue Language
dc.contributor.authorSnaedal, J-
dc.contributor.authorKristinsson, J-
dc.contributor.authorGunnarsdottir, S-
dc.contributor.authorOlafsdottir-
dc.contributor.authorBaldvinsson, M-
dc.contributor.authorJohannesson, T-
dc.date.accessioned2009-01-26T11:58:02Z-
dc.date.available2009-01-26T11:58:02Z-
dc.date.issued1998-10-
dc.date.submitted2009-01-26-
dc.identifier.citationDement Geriatr Cogn Disord. 1998, 9(5):239-42en
dc.identifier.issn1420-8008-
dc.identifier.pmid9701674-
dc.identifier.doi10.1159/000017067-
dc.identifier.urihttp://hdl.handle.net/2336/48001-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThe copper-containing enzyme superoxide dismutase (SOD) is a key enzyme in suppressing the amounts of superoxide anion radicals. Ceruloplasmin, the copper-transporting protein in plasma, also possesses an important redox capacity. In this study the levels of copper and ceruloplasmin as well as SOD-activity and ceruloplasmin oxidative activity were analyzed in order to throw some light on possible defects in copper mechanisms in patients diagnosed with Alzheimer's disease (AD). The study included 44 patients with AD and their healthy age- and gender-matched controls. No difference of significance was seen when comparing the copper or ceruloplasmin concentration in plasma of AD patients to that of their paired controls. The SOD activity in red blood cells was significantly lower in the patients than in their controls (p = 0.019). The ceruloplasmin oxidative activity in plasma of Alzheimer's patients was greatly reduced as compared to that of age- and gender-matched controls and the difference was highly significant (p = 0.0005). Ceruloplasmin activity and SOD activity were not found to be intrinsically correlated. It was postulated that reduced oxidative activity of ceruloplasmin in plasma might be either a cause or a consequence of AD and that reduced SOD activity might further add to the oxidative disturbances in AD due to defective ceruloplasmin activity.en
dc.language.isoenen
dc.publisherKargeren
dc.relation.urlhttp://proquest.umi.com/pqdweb?did=34446148&sid=2&Fmt=4&clientId=58120&RQT=309&VName=PQDen
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAlzheimer Diseaseen
dc.subject.meshCase-Control Studiesen
dc.subject.meshCeruloplasminen
dc.subject.meshCopperen
dc.subject.meshErythrocytesen
dc.subject.meshFemaleen
dc.subject.meshFree Radicalsen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshOxidation-Reductionen
dc.subject.meshSuperoxide Dismutaseen
dc.titleCopper, ceruloplasmin and superoxide dismutase in patients with Alzheimer's disease . a case-control studyen
dc.typeArticleen
dc.contributor.departmentGeriatric Department, Reykjavik Hospital, University of Iceland, Reykjavik, Iceland.en
dc.identifier.journalDementia and geriatric cognitive disordersen

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