Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.

2.22
Hdl Handle:
http://hdl.handle.net/2336/48004
Title:
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
Authors:
Thorleifsson, Gudmar; Walters, G Bragi; Gudbjartsson, Daniel F; Steinthorsdottir, Valgerdur; Sulem, Patrick; Helgadottir, Anna; Styrkarsdottir, Unnur; Gretarsdottir, Solveig; Thorlacius, Steinunn; Jonsdottir, Ingileif; Jonsdottir, Thorbjorg; Olafsdottir, Elinborg J; Olafsdottir, Gudridur H; Jonsson, Thorvaldur; Jonsson, Frosti; Borch-Johnsen, Knut; Hansen, Torben; Andersen, Gitte; Jorgensen, Torben; Lauritzen, Torsten; Aben, Katja K; Verbeek, André L M; Roeleveld, Nel; Kampman, Ellen; Yanek, Lisa R; Becker, Lewis C; Tryggvadottir, Laufey; Rafnar, Thorunn; Becker, Diane M; Gulcher, Jeffrey; Kiemeney, Lambertus A; Pedersen, Oluf; Kong, Augustine; Thorsteinsdottir, Unnur; Stefansson, Kari
Citation:
Nat. Genet. 2009, 41(1):18-24
Issue Date:
1-Jan-2009
Abstract:
Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are highly heritable, we performed a genome-wide association (GWA) study with 305,846 SNPs typed in 25,344 Icelandic, 2,998 Dutch, 1,890 European Americans and 1,160 African American subjects and combined the results with previously published results from the Diabetes Genetics Initiative (DGI) on 3,024 Scandinavians. We selected 43 variants in 19 regions for follow-up in 5,586 Danish individuals and compared the results to a genome-wide study on obesity-related traits from the GIANT consortium. In total, 29 variants, some correlated, in 11 chromosomal regions reached a genome-wide significance threshold of P < 1.6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/ng.274

Full metadata record

DC FieldValue Language
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorWalters, G Bragi-
dc.contributor.authorGudbjartsson, Daniel F-
dc.contributor.authorSteinthorsdottir, Valgerdur-
dc.contributor.authorSulem, Patrick-
dc.contributor.authorHelgadottir, Anna-
dc.contributor.authorStyrkarsdottir, Unnur-
dc.contributor.authorGretarsdottir, Solveig-
dc.contributor.authorThorlacius, Steinunn-
dc.contributor.authorJonsdottir, Ingileif-
dc.contributor.authorJonsdottir, Thorbjorg-
dc.contributor.authorOlafsdottir, Elinborg J-
dc.contributor.authorOlafsdottir, Gudridur H-
dc.contributor.authorJonsson, Thorvaldur-
dc.contributor.authorJonsson, Frosti-
dc.contributor.authorBorch-Johnsen, Knut-
dc.contributor.authorHansen, Torben-
dc.contributor.authorAndersen, Gitte-
dc.contributor.authorJorgensen, Torben-
dc.contributor.authorLauritzen, Torsten-
dc.contributor.authorAben, Katja K-
dc.contributor.authorVerbeek, André L M-
dc.contributor.authorRoeleveld, Nel-
dc.contributor.authorKampman, Ellen-
dc.contributor.authorYanek, Lisa R-
dc.contributor.authorBecker, Lewis C-
dc.contributor.authorTryggvadottir, Laufey-
dc.contributor.authorRafnar, Thorunn-
dc.contributor.authorBecker, Diane M-
dc.contributor.authorGulcher, Jeffrey-
dc.contributor.authorKiemeney, Lambertus A-
dc.contributor.authorPedersen, Oluf-
dc.contributor.authorKong, Augustine-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2009-01-26T13:30:11Z-
dc.date.available2009-01-26T13:30:11Z-
dc.date.issued2009-01-01-
dc.date.submitted2009-01-26-
dc.identifier.citationNat. Genet. 2009, 41(1):18-24en
dc.identifier.issn1546-1718-
dc.identifier.pmid19079260-
dc.identifier.doi10.1038/ng.274-
dc.identifier.urihttp://hdl.handle.net/2336/48004-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractObesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are highly heritable, we performed a genome-wide association (GWA) study with 305,846 SNPs typed in 25,344 Icelandic, 2,998 Dutch, 1,890 European Americans and 1,160 African American subjects and combined the results with previously published results from the Diabetes Genetics Initiative (DGI) on 3,024 Scandinavians. We selected 43 variants in 19 regions for follow-up in 5,586 Danish individuals and compared the results to a genome-wide study on obesity-related traits from the GIANT consortium. In total, 29 variants, some correlated, in 11 chromosomal regions reached a genome-wide significance threshold of P < 1.6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity.en
dc.language.isoenen
dc.publisherNature Pub. Co.en
dc.relation.urlhttp://dx.doi.org/10.1038/ng.274en
dc.subject.meshBase Sequenceen
dc.subject.meshBody Mass Indexen
dc.subject.meshBody Weighten
dc.subject.meshDiabetes Mellitus, Type 2en
dc.subject.meshGene Expression Regulationen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshGenome, Humanen
dc.subject.meshGenome-Wide Association Studyen
dc.subject.meshHumansen
dc.subject.meshObesityen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshQuantitative Trait Locien
dc.subject.meshQuantitative Trait, Heritableen
dc.titleGenome-wide association yields new sequence variants at seven loci that associate with measures of obesity.en
dc.typeArticleen
dc.contributor.departmentdeCODE Genetics, Reykjavik, Iceland. thorleif@decode.isen
dc.identifier.journalNature geneticsen

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.