2.50
Hdl Handle:
http://hdl.handle.net/2336/48005
Title:
New sequence variants associated with bone mineral density.
Authors:
Styrkarsdottir, Unnur; Halldorsson, Bjarni V; Gretarsdottir, Solveig; Gudbjartsson, Daniel F; Walters, G Bragi; Ingvarsson, Thorvaldur; Jonsdottir, Thorbjorg; Saemundsdottir, Jona; Snorradóttir, Steinunn; Center, Jacqueline R; Nguyen, Tuan V; Alexandersen, Peter; Gulcher, Jeffrey R; Eisman, John A; Christiansen, Claus; Sigurdsson, Gunnar; Kong, Augustine; Thorsteinsdottir, Unnur; Stefansson, Kari
Citation:
Nat. Genet. 2009, 41(1):15-7
Issue Date:
1-Jan-2009
Abstract:
In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/ng.284

Full metadata record

DC FieldValue Language
dc.contributor.authorStyrkarsdottir, Unnur-
dc.contributor.authorHalldorsson, Bjarni V-
dc.contributor.authorGretarsdottir, Solveig-
dc.contributor.authorGudbjartsson, Daniel F-
dc.contributor.authorWalters, G Bragi-
dc.contributor.authorIngvarsson, Thorvaldur-
dc.contributor.authorJonsdottir, Thorbjorg-
dc.contributor.authorSaemundsdottir, Jona-
dc.contributor.authorSnorradóttir, Steinunn-
dc.contributor.authorCenter, Jacqueline R-
dc.contributor.authorNguyen, Tuan V-
dc.contributor.authorAlexandersen, Peter-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorEisman, John A-
dc.contributor.authorChristiansen, Claus-
dc.contributor.authorSigurdsson, Gunnar-
dc.contributor.authorKong, Augustine-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2009-01-26T13:47:00Z-
dc.date.available2009-01-26T13:47:00Z-
dc.date.issued2009-01-01-
dc.date.submitted2009-01-26-
dc.identifier.citationNat. Genet. 2009, 41(1):15-7en
dc.identifier.issn1546-1718-
dc.identifier.pmid19079262-
dc.identifier.doi10.1038/ng.284-
dc.identifier.urihttp://hdl.handle.net/2336/48005-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractIn an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.en
dc.language.isoenen
dc.publisherNature Pub. Co.en
dc.relation.urlhttp://dx.doi.org/10.1038/ng.284en
dc.subject.meshBase Sequenceen
dc.subject.meshBone Densityen
dc.subject.meshChromosomes, Human, Pair 17en
dc.subject.meshFemaleen
dc.subject.meshFractures, Boneen
dc.subject.meshGenome-Wide Association Studyen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshWounds and Injuriesen
dc.titleNew sequence variants associated with bone mineral density.en
dc.typeArticleen
dc.contributor.departmentdeCODE Genetics, Reykjavik, Iceland. unnur.styrkarsdottir@decode.isen
dc.identifier.journalNature geneticsen

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