T-and B-lymphocyte subsets in patients with Dupuytren's disease. Correlations with disease severity

2.50
Hdl Handle:
http://hdl.handle.net/2336/49000
Title:
T-and B-lymphocyte subsets in patients with Dupuytren's disease. Correlations with disease severity
Authors:
Gudmundsson, K G; Arngrimsson, R; Arinbjarnarson, S; Olafsson, A; Jonsson, T
Citation:
J Hand Surg [Br] 1998, 23(6):724-7
Issue Date:
1-Dec-1998
Abstract:
Previous reports have indicated that inflammatory mechanisms may be involved in the pathogenesis of Dupuytren's disease and it has even been suggested that this condition is a T-cell mediated autoimmune disorder. We investigated peripheral blood lymphocyte subsets from 21 patients with Dupuytren's disease and compared them with ten healthy blood donors. The Dupuytren's patients had an increase in DR+ T-cells compared with healthy controls. Furthermore, patients with both palmar and plantar involvement had a higher percentage of DR+ T-cells than those with only the palm affected. The percentage of circulating CD5+ B-cells was lower in the Dupuytren's patients compared with the control group; this feature was marginally significant for the whole group of Dupuytren's patients but was strongest in the group of patients with both palmar and plantar involvement. These findings support previous suggestions that immunological mechanisms, involving activated T-cells and probably also B-cells, are involved in the pathogenesis of Dupuytren's disease.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B6WJM-4H527JV-4/2/213bf9dd87b88a4e435b86c3d8cf8d31

Full metadata record

DC FieldValue Language
dc.contributor.authorGudmundsson, K G-
dc.contributor.authorArngrimsson, R-
dc.contributor.authorArinbjarnarson, S-
dc.contributor.authorOlafsson, A-
dc.contributor.authorJonsson, T-
dc.date.accessioned2009-02-12T15:02:26Z-
dc.date.available2009-02-12T15:02:26Z-
dc.date.issued1998-12-01-
dc.date.submitted2009-02-12-
dc.identifier.citationJ Hand Surg [Br] 1998, 23(6):724-7en
dc.identifier.issn0266-7681-
dc.identifier.pmid9888668-
dc.identifier.doi10.1016/S0266-7681(98)80083-1-
dc.identifier.urihttp://hdl.handle.net/2336/49000-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPrevious reports have indicated that inflammatory mechanisms may be involved in the pathogenesis of Dupuytren's disease and it has even been suggested that this condition is a T-cell mediated autoimmune disorder. We investigated peripheral blood lymphocyte subsets from 21 patients with Dupuytren's disease and compared them with ten healthy blood donors. The Dupuytren's patients had an increase in DR+ T-cells compared with healthy controls. Furthermore, patients with both palmar and plantar involvement had a higher percentage of DR+ T-cells than those with only the palm affected. The percentage of circulating CD5+ B-cells was lower in the Dupuytren's patients compared with the control group; this feature was marginally significant for the whole group of Dupuytren's patients but was strongest in the group of patients with both palmar and plantar involvement. These findings support previous suggestions that immunological mechanisms, involving activated T-cells and probably also B-cells, are involved in the pathogenesis of Dupuytren's disease.en
dc.language.isoenen
dc.publisherChurchill Livingstoneen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6WJM-4H527JV-4/2/213bf9dd87b88a4e435b86c3d8cf8d31en
dc.subject.meshAdulten
dc.subject.meshB-Lymphocyte Subsetsen
dc.subject.meshDupuytren's Contractureen
dc.subject.meshFemaleen
dc.subject.meshFlow Cytometryen
dc.subject.meshHumansen
dc.subject.meshImmunity, Cellularen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshSeverity of Illness Indexen
dc.subject.meshStatistics, Nonparametricen
dc.subject.meshT-Lymphocyte Subsetsen
dc.titleT-and B-lymphocyte subsets in patients with Dupuytren's disease. Correlations with disease severityen
dc.typeArticleen
dc.contributor.departmentThe Health Care Center and Region Hospital, Blonduos, Iceland.en
dc.identifier.journalJournal of hand surgery (Edinburgh, Scotland)en

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