2.50
Hdl Handle:
http://hdl.handle.net/2336/49016
Title:
Association between exposure to crystalline silica and risk of sarcoidosis.
Authors:
Rafnsson, V; Ingimarsson, O; Hjalmarsson, I; Gunnarsdottir, H
Citation:
Occup Environ Med 1998, 55(10):657-60
Issue Date:
1-Oct-1998
Abstract:
OBJECTIVES: The possibility of an association between exposure to silica and autoimmune diseases has recently come under discussion. In the following case-referent study, a cohort exposed to diatomaceous earth and cristobalite provided an opportunity to evaluate such an exposure with reference to sarcoidosis. METHODS: The inhabitants of a district served by a single healthcare centre and a hospital formed the study base. A diatomaceous earth plant is located in this community and the medical institutions are responsible for primary and secondary health care of the population. Cases of sarcoidosis were identified from the hospital records according to certain clinical, radiological, and histological criteria. Referents were selected randomly from the population of the district. Information on exposure to crystalline silica, cristobalite, was obtained by record linkage of the cases and referents with a file which included all present and past workers at the diatomaceous earth plant and those who had worked at loading vessels with the product from the plant. RESULTS: Eight cases of sarcoidosis were found, six of which were in the exposed group. Of the 70 referents, 13 were exposed. The odds ratio (95% confidence interval) was 13.2 (2.0 to 140.9). CONCLUSION: The odds ratios were high and there were some indications of a dose-response relation which will hopefully encourage further studies. To our knowledge this is the first study to indicate a relation between sarcoidosis and exposure to the crystalline silica, cristobalite.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9930085

Full metadata record

DC FieldValue Language
dc.contributor.authorRafnsson, V-
dc.contributor.authorIngimarsson, O-
dc.contributor.authorHjalmarsson, I-
dc.contributor.authorGunnarsdottir, H-
dc.date.accessioned2009-02-12T14:02:48Z-
dc.date.available2009-02-12T14:02:48Z-
dc.date.issued1998-10-01-
dc.date.submitted2009-02-12-
dc.identifier.citationOccup Environ Med 1998, 55(10):657-60en
dc.identifier.issn1351-0711-
dc.identifier.pmid9930085-
dc.identifier.urihttp://hdl.handle.net/2336/49016-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVES: The possibility of an association between exposure to silica and autoimmune diseases has recently come under discussion. In the following case-referent study, a cohort exposed to diatomaceous earth and cristobalite provided an opportunity to evaluate such an exposure with reference to sarcoidosis. METHODS: The inhabitants of a district served by a single healthcare centre and a hospital formed the study base. A diatomaceous earth plant is located in this community and the medical institutions are responsible for primary and secondary health care of the population. Cases of sarcoidosis were identified from the hospital records according to certain clinical, radiological, and histological criteria. Referents were selected randomly from the population of the district. Information on exposure to crystalline silica, cristobalite, was obtained by record linkage of the cases and referents with a file which included all present and past workers at the diatomaceous earth plant and those who had worked at loading vessels with the product from the plant. RESULTS: Eight cases of sarcoidosis were found, six of which were in the exposed group. Of the 70 referents, 13 were exposed. The odds ratio (95% confidence interval) was 13.2 (2.0 to 140.9). CONCLUSION: The odds ratios were high and there were some indications of a dose-response relation which will hopefully encourage further studies. To our knowledge this is the first study to indicate a relation between sarcoidosis and exposure to the crystalline silica, cristobalite.en
dc.language.isoenen
dc.publisherBMJ Pub. Groupen
dc.relation.urlhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9930085en
dc.subject.meshAdulten
dc.subject.meshConfidence Intervalsen
dc.subject.meshEnvironmental Exposureen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshOdds Ratioen
dc.subject.meshRisk Factorsen
dc.subject.meshSarcoidosis, Pulmonaryen
dc.subject.meshSilicon Dioxideen
dc.subject.meshTime Factorsen
dc.titleAssociation between exposure to crystalline silica and risk of sarcoidosis.en
dc.typeArticleen
dc.identifier.eissn1470-7926-
dc.contributor.departmentDepartment of Preventive Medicine, University of Iceland, Reykjavik, Iceland. vilraf@rahi.hi.isen
dc.identifier.journalOccupational and environmental medicineen

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