Activated and total coagulation factor VII, and fibrinogen in coronary artery disease

2.50
Hdl Handle:
http://hdl.handle.net/2336/49174
Title:
Activated and total coagulation factor VII, and fibrinogen in coronary artery disease
Authors:
Danielsen, R; Onundarson, P T; Thors, H; Vidarsson, B; Morrissey, J H
Citation:
Scand. Cardiovasc. J. 1998, 32(2):87-95
Issue Date:
1-Mar-1998
Abstract:
Fibrinogen (FBG) and total coagulation factor VII (FVIIc) concentrations are higher in those patients with coronary artery disease who are at increased future risk of acute ischemic events. The relationship between activated factor VII (FVIIa) and cardiovascular events, however, has not been intensively studied. Data were collected from 401 consecutive patients who underwent coronary angiography because of suspected coronary artery disease. Conventional risk factors FVIIc, FVIIa and FBG were assessed in relation to the severity of coronary artery disease, left ventricular ejection fraction, and previous clinical events. A strong positive correlation was found between FVIIa and FVIIc (p < 0.001), but neither FVIIa nor FVIIc correlated with FBG. No correlation was found between FVIIa, FVIIc or FBG levels and stenosis score for the severity of coronary artery disease, and all were similar in patients with stable or unstable angina pectoris. Multivariate regression analysis showed FVIIc to be higher in women (p = 0.004), and positively related to triglycerides (p = 0.001) and HDL cholesterol (p = 0.006), but not to a previous myocardial infarction or total cholesterol. FVIIa, on the other hand, was lower in patients with a previous myocardial infarction (p = 0.004), higher in women (p = 0.001) and those that previously had undergone percutaneous transluminal coronary angioplasty (p = 0.039), and positively related to total cholesterol (p = 0.011), duration of coronary artery disease (p = 0.032), and smoking (p = 0.008). FBG was positively associated with a previous myocardial infarction (p = 0.013), hypertension (p = 0.016), smoking (p = 0.005), and the thrombocyte count (p < 0.001). Finally, stepwise logistic regression analysis verified a previous myocardial infarction to be negatively associated with FVIIa (p = 0.03), and positively with FBG (p = 0.03), total cholesterol (p = 0.02), and the severity of coronary artery disease (p < 0.001). In conclusion, in patients suspected of coronary artery disease undergoing cardiac catheterization, FVIIa was decreased and FBG increased in those who had a previous myocardial infarction. FVIIa, FVIIc, or FBG levels were not, however, related to the severity of coronary artery disease, and they were similar in patients with stable or unstable angina pectoris.
Description:
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Full metadata record

DC FieldValue Language
dc.contributor.authorDanielsen, R-
dc.contributor.authorOnundarson, P T-
dc.contributor.authorThors, H-
dc.contributor.authorVidarsson, B-
dc.contributor.authorMorrissey, J H-
dc.date.accessioned2009-02-16T09:55:00Z-
dc.date.available2009-02-16T09:55:00Z-
dc.date.issued1998-03-01-
dc.date.submitted2009-02-16-
dc.identifier.citationScand. Cardiovasc. J. 1998, 32(2):87-95en
dc.identifier.issn1401-7431-
dc.identifier.pmid9636964-
dc.identifier.doi10.1080/14017439850140238-
dc.identifier.urihttp://hdl.handle.net/2336/49174-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractFibrinogen (FBG) and total coagulation factor VII (FVIIc) concentrations are higher in those patients with coronary artery disease who are at increased future risk of acute ischemic events. The relationship between activated factor VII (FVIIa) and cardiovascular events, however, has not been intensively studied. Data were collected from 401 consecutive patients who underwent coronary angiography because of suspected coronary artery disease. Conventional risk factors FVIIc, FVIIa and FBG were assessed in relation to the severity of coronary artery disease, left ventricular ejection fraction, and previous clinical events. A strong positive correlation was found between FVIIa and FVIIc (p < 0.001), but neither FVIIa nor FVIIc correlated with FBG. No correlation was found between FVIIa, FVIIc or FBG levels and stenosis score for the severity of coronary artery disease, and all were similar in patients with stable or unstable angina pectoris. Multivariate regression analysis showed FVIIc to be higher in women (p = 0.004), and positively related to triglycerides (p = 0.001) and HDL cholesterol (p = 0.006), but not to a previous myocardial infarction or total cholesterol. FVIIa, on the other hand, was lower in patients with a previous myocardial infarction (p = 0.004), higher in women (p = 0.001) and those that previously had undergone percutaneous transluminal coronary angioplasty (p = 0.039), and positively related to total cholesterol (p = 0.011), duration of coronary artery disease (p = 0.032), and smoking (p = 0.008). FBG was positively associated with a previous myocardial infarction (p = 0.013), hypertension (p = 0.016), smoking (p = 0.005), and the thrombocyte count (p < 0.001). Finally, stepwise logistic regression analysis verified a previous myocardial infarction to be negatively associated with FVIIa (p = 0.03), and positively with FBG (p = 0.03), total cholesterol (p = 0.02), and the severity of coronary artery disease (p < 0.001). In conclusion, in patients suspected of coronary artery disease undergoing cardiac catheterization, FVIIa was decreased and FBG increased in those who had a previous myocardial infarction. FVIIa, FVIIc, or FBG levels were not, however, related to the severity of coronary artery disease, and they were similar in patients with stable or unstable angina pectoris.en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urlhttp://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=8680208&site=ehost-liveen
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAngina Pectorisen
dc.subject.meshCholesterolen
dc.subject.meshCholesterol, HDLen
dc.subject.meshCoronary Angiographyen
dc.subject.meshCoronary Artery Diseaseen
dc.subject.meshCoronary Diseaseen
dc.subject.meshCoronary Thrombosisen
dc.subject.meshDisease Progressionen
dc.subject.meshFactor VIIen
dc.subject.meshFactor VIIaen
dc.subject.meshFemaleen
dc.subject.meshFibrinogenen
dc.subject.meshHeart Catheterizationen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshMultivariate Analysisen
dc.subject.meshMyocardial Infarctionen
dc.subject.meshProspective Studiesen
dc.subject.meshRegression Analysisen
dc.subject.meshRisk Assessmenten
dc.subject.meshSex Characteristicsen
dc.subject.meshTriglyceridesen
dc.titleActivated and total coagulation factor VII, and fibrinogen in coronary artery diseaseen
dc.typeArticleen
dc.contributor.departmentDepartment of Medicine, Landspítalinn, University Hospital, Reykjavik, Iceland.en
dc.identifier.journalScandinavian cardiovascular journal : SCJen

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