2.50
Hdl Handle:
http://hdl.handle.net/2336/49474
Title:
Long-term survival of people with unprovoked seizures: a population-based study.
Authors:
Olafsson, E; Hauser, W A; Gudmundsson, G
Citation:
Epilepsia. 1998, 39(1):89-92
Issue Date:
1-Jan-1998
Abstract:
PURPOSE: Few population-based studies of long-term survival in people with seizures or epilepsy have been made. METHODS: Between January 1, 1960 and December 31, 1964, we identified 224 incidence cases of unprovoked seizures in Iceland and determined survivorship status and date of death for the cases as of January 1, 1996. We compared survivorship with that expected based on data from age-/sex-specific life tables from the country for 1961-1990 and calculated the standardized mortality ratio (SMR). RESULTS: By 30 years after diagnosis, there were 45 deaths among patients with unprovoked seizures as compared with an expected 28 deaths [standardized mortality ratio (SMR) 1.6; 95% confidence interval (CI) 1.2-2.2]. Patients with unprovoked seizures of unknown etiology did not have a significant increase in mortality overall (SMR 1.3, 95% CI 0.8-1.9) or in any time interval. For patients with remote symptomatic unprovoked seizures, mortality was increased (SMR 2.3, 95% CI 1.4-3.5). This increase was attributable to excess mortality for the first 15 years after diagnosis (SMR 4.1, 95% CI 2.4-6.6), and SMR was not different after that time. CONCLUSIONS: Survivorship was decreased for the population of patients with unprovoked seizures. The increased mortality was primarily due to excess mortality in patients with remote symptomatic seizures, occurring in the first 15 years after diagnosis. Overall mortality for idiopathic unprovoked seizures was not significantly increased.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1111/j.1528-1157.1998.tb01279.x

Full metadata record

DC FieldValue Language
dc.contributor.authorOlafsson, E-
dc.contributor.authorHauser, W A-
dc.contributor.authorGudmundsson, G-
dc.date.accessioned2009-02-19T09:58:48Z-
dc.date.available2009-02-19T09:58:48Z-
dc.date.issued1998-01-01-
dc.date.submitted2009-02-20-
dc.identifier.citationEpilepsia. 1998, 39(1):89-92en
dc.identifier.issn0013-9580-
dc.identifier.pmid9578018-
dc.identifier.doi10.1111/j.1528-1157.1998.tb01279.x-
dc.identifier.urihttp://hdl.handle.net/2336/49474-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPURPOSE: Few population-based studies of long-term survival in people with seizures or epilepsy have been made. METHODS: Between January 1, 1960 and December 31, 1964, we identified 224 incidence cases of unprovoked seizures in Iceland and determined survivorship status and date of death for the cases as of January 1, 1996. We compared survivorship with that expected based on data from age-/sex-specific life tables from the country for 1961-1990 and calculated the standardized mortality ratio (SMR). RESULTS: By 30 years after diagnosis, there were 45 deaths among patients with unprovoked seizures as compared with an expected 28 deaths [standardized mortality ratio (SMR) 1.6; 95% confidence interval (CI) 1.2-2.2]. Patients with unprovoked seizures of unknown etiology did not have a significant increase in mortality overall (SMR 1.3, 95% CI 0.8-1.9) or in any time interval. For patients with remote symptomatic unprovoked seizures, mortality was increased (SMR 2.3, 95% CI 1.4-3.5). This increase was attributable to excess mortality for the first 15 years after diagnosis (SMR 4.1, 95% CI 2.4-6.6), and SMR was not different after that time. CONCLUSIONS: Survivorship was decreased for the population of patients with unprovoked seizures. The increased mortality was primarily due to excess mortality in patients with remote symptomatic seizures, occurring in the first 15 years after diagnosis. Overall mortality for idiopathic unprovoked seizures was not significantly increased.en
dc.language.isoenen
dc.publisherBlackwell Scienceen
dc.relation.urlhttp://dx.doi.org/10.1111/j.1528-1157.1998.tb01279.xen
dc.subject.meshAdulten
dc.subject.meshAge Factorsen
dc.subject.meshConfidence Intervalsen
dc.subject.meshEpilepsyen
dc.subject.meshFemaleen
dc.subject.meshFollow-Up Studiesen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshIncidenceen
dc.subject.meshLife Tablesen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshSeizuresen
dc.subject.meshSex Factorsen
dc.subject.meshSurvival Analysisen
dc.titleLong-term survival of people with unprovoked seizures: a population-based study.en
dc.typeArticleen
dc.identifier.eissn1528-1167-
dc.contributor.departmentDepartment of Neurology, National University Hospital, Reykjavik, Iceland.en
dc.identifier.journalEpilepsiaen

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