Carbonic anhydrase inhibition increases retinal oxygen tension and dilates retinal vessels

2.50
Hdl Handle:
http://hdl.handle.net/2336/53313
Title:
Carbonic anhydrase inhibition increases retinal oxygen tension and dilates retinal vessels
Authors:
Pedersen, Daniella Bach; Koch Jensen, Peter; la Cour, Morten; Kiilgaard, Jens Folke; Eysteinsson, Thor; Bang, Kurt; Wiencke, Anne Kathrine; Stefansson, Einar
Citation:
Graefes Arch. Clin. Exp. Ophthalmol. 2005, 243(2):163-8
Issue Date:
1-Feb-2005
Abstract:
BACKGROUND: Carbonic anhydrase inhibitors (CAIs) increase blood flow in the brain and probably also in the optic nerve and retina. Additionally they elevate the oxygen tension in the optic nerve in the pig. We propose that they also raise the oxygen tension in the retina. We studied the oxygen tension in the pig retina and optic nerve before and after dorzolamide injection. Also the retinal vessel diameters during carbonic anhydrase inhibition were studied. METHODS: A polarographic oxygen electrode was placed transvitreally immediately over the retina or the optic disc in anaesthetised pigs. The oxygen tension was recorded continually and 500 mg dorzolamide was injected intravenously. Retinal vessel diameters were analysed from monochromatic fundus photographs taken before and after injection of dorzolamide. RESULTS: Baseline retinal oxygen tension (RPO2) was 3.34+/-0.50 kPa (mean +/- SD, n=6) and baseline optic nerve oxygen tension (ONPO2) was 3.63+/-1.00 kPa. RPO2 was increased by 0.36+/-0.11 kPa (n=6, P=0.025) and ONPO2 by 0.73+/-0.34 kPa (n=6, P=0.003) 30 min after dorzolamide administration. The retinal arterioles was significantly dilated by 13+/-7% (n=5, P=0.016) and the retinal venules by 12+/-8% (n=5, P=0.030) 30 min after injection of dorzolamide. CONCLUSION: Retinal and optic nerve oxygen tension increased with systemic administration of dorzolamide. The retinal vessels dilated, probably causing increased blood flow inducing the observed increase in RPO2. The increased oxygenation of retina by CAI may offer therapeutic possibilities in ischaemic diseases of the retina and optic nerve.
Description:
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Additional Links:
http://www.springerlink.com/content/kh2a7mcp14nwxfj5

Full metadata record

DC FieldValue Language
dc.contributor.authorPedersen, Daniella Bach-
dc.contributor.authorKoch Jensen, Peter-
dc.contributor.authorla Cour, Morten-
dc.contributor.authorKiilgaard, Jens Folke-
dc.contributor.authorEysteinsson, Thor-
dc.contributor.authorBang, Kurt-
dc.contributor.authorWiencke, Anne Kathrine-
dc.contributor.authorStefansson, Einar-
dc.date.accessioned2009-03-09T13:55:56Z-
dc.date.available2009-03-09T13:55:56Z-
dc.date.issued2005-02-01-
dc.date.submitted2009-03-09-
dc.identifier.citationGraefes Arch. Clin. Exp. Ophthalmol. 2005, 243(2):163-8en
dc.identifier.issn0721-832X-
dc.identifier.pmid15742212-
dc.identifier.doi10.1007/s00417-003-0817-3-
dc.identifier.urihttp://hdl.handle.net/2336/53313-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Carbonic anhydrase inhibitors (CAIs) increase blood flow in the brain and probably also in the optic nerve and retina. Additionally they elevate the oxygen tension in the optic nerve in the pig. We propose that they also raise the oxygen tension in the retina. We studied the oxygen tension in the pig retina and optic nerve before and after dorzolamide injection. Also the retinal vessel diameters during carbonic anhydrase inhibition were studied. METHODS: A polarographic oxygen electrode was placed transvitreally immediately over the retina or the optic disc in anaesthetised pigs. The oxygen tension was recorded continually and 500 mg dorzolamide was injected intravenously. Retinal vessel diameters were analysed from monochromatic fundus photographs taken before and after injection of dorzolamide. RESULTS: Baseline retinal oxygen tension (RPO2) was 3.34+/-0.50 kPa (mean +/- SD, n=6) and baseline optic nerve oxygen tension (ONPO2) was 3.63+/-1.00 kPa. RPO2 was increased by 0.36+/-0.11 kPa (n=6, P=0.025) and ONPO2 by 0.73+/-0.34 kPa (n=6, P=0.003) 30 min after dorzolamide administration. The retinal arterioles was significantly dilated by 13+/-7% (n=5, P=0.016) and the retinal venules by 12+/-8% (n=5, P=0.030) 30 min after injection of dorzolamide. CONCLUSION: Retinal and optic nerve oxygen tension increased with systemic administration of dorzolamide. The retinal vessels dilated, probably causing increased blood flow inducing the observed increase in RPO2. The increased oxygenation of retina by CAI may offer therapeutic possibilities in ischaemic diseases of the retina and optic nerve.en
dc.language.isoenen
dc.publisherSpringer-Verlagen
dc.relation.urlhttp://www.springerlink.com/content/kh2a7mcp14nwxfj5en
dc.subject.meshAnimalsen
dc.subject.meshCarbonic Anhydrase Inhibitorsen
dc.subject.meshCarbonic Anhydrasesen
dc.subject.meshInjections, Intravenousen
dc.subject.meshIon-Selective Electrodesen
dc.subject.meshOptic Nerveen
dc.subject.meshOxygenen
dc.subject.meshPartial Pressureen
dc.subject.meshPolarographyen
dc.subject.meshRetinaen
dc.subject.meshRetinal Vesselsen
dc.subject.meshSulfonamidesen
dc.subject.meshSwineen
dc.subject.meshThiophenesen
dc.subject.meshVasodilationen
dc.titleCarbonic anhydrase inhibition increases retinal oxygen tension and dilates retinal vesselsen
dc.typeArticleen
dc.contributor.departmentDepartment of Ophthalmology, 2061, Rigshospitalet, Blegdamsvej 9, 2100 , Copenhagen Ø, Denmark. daniella@dadlnet.dken
dc.identifier.journalGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologieen

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