Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions

2.50
Hdl Handle:
http://hdl.handle.net/2336/54113
Title:
Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions
Authors:
Tollin, M; Bergsson, G; Kai-Larsen, Y; Lengqvist, J; Sjövall, J; Griffiths, W; Skuladottir, G V; Haraldsson, A; Jörnvall, H; Gudmundsson, G H; Agerberth, B
Citation:
Cell. Mol. Life Sci. 2005, 62(19-20):2390-9
Issue Date:
1-Oct-2005
Abstract:
Vernix caseosa is a white cream-like substance that covers the skin of the foetus and the newborn baby. Recently, we discovered antimicrobial peptides/proteins such as LL-37 in vernix, suggesting host defence functions of vernix. In a proteomic approach, we have continued to characterize proteins in vernix and have identified 20 proteins, plus additional variant forms. The novel proteins identified, considered to be involved in host defence, are cystatin A, UGRP-1, and calgranulin A, B and C. These proteins add protective functions to vernix such as antifungal activity, opsonizing capacity, protease inhibition and parasite inactivation. The composition of the lipids in vernix has also been characterized and among these compounds the free fatty acids were found to exhibit antimicrobial activity. Interestingly, the vernix lipids enhance the antimicrobial activity of LL-37 in vitro, indicating interactions between lipids and antimicrobial peptides in vernix. In conclusion, vernix is a balanced cream of compounds involved in host defence, protecting the foetus and newborn against infection.
Description:
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Additional Links:
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Full metadata record

DC FieldValue Language
dc.contributor.authorTollin, M-
dc.contributor.authorBergsson, G-
dc.contributor.authorKai-Larsen, Y-
dc.contributor.authorLengqvist, J-
dc.contributor.authorSjövall, J-
dc.contributor.authorGriffiths, W-
dc.contributor.authorSkuladottir, G V-
dc.contributor.authorHaraldsson, A-
dc.contributor.authorJörnvall, H-
dc.contributor.authorGudmundsson, G H-
dc.contributor.authorAgerberth, B-
dc.date.accessioned2009-03-11T09:56:37Z-
dc.date.available2009-03-11T09:56:37Z-
dc.date.issued2005-10-01-
dc.date.submitted2009-03-11-
dc.identifier.citationCell. Mol. Life Sci. 2005, 62(19-20):2390-9en
dc.identifier.issn1420-682X-
dc.identifier.pmid16179970-
dc.identifier.doi10.1007/s00018-005-5260-7-
dc.identifier.urihttp://hdl.handle.net/2336/54113-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractVernix caseosa is a white cream-like substance that covers the skin of the foetus and the newborn baby. Recently, we discovered antimicrobial peptides/proteins such as LL-37 in vernix, suggesting host defence functions of vernix. In a proteomic approach, we have continued to characterize proteins in vernix and have identified 20 proteins, plus additional variant forms. The novel proteins identified, considered to be involved in host defence, are cystatin A, UGRP-1, and calgranulin A, B and C. These proteins add protective functions to vernix such as antifungal activity, opsonizing capacity, protease inhibition and parasite inactivation. The composition of the lipids in vernix has also been characterized and among these compounds the free fatty acids were found to exhibit antimicrobial activity. Interestingly, the vernix lipids enhance the antimicrobial activity of LL-37 in vitro, indicating interactions between lipids and antimicrobial peptides in vernix. In conclusion, vernix is a balanced cream of compounds involved in host defence, protecting the foetus and newborn against infection.en
dc.language.isoenen
dc.publisherBirkhauseren
dc.relation.urlhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2315785en
dc.subject.meshAmino Acid Sequenceen
dc.subject.meshAnti-Infective Agentsen
dc.subject.meshAntimicrobial Cationic Peptidesen
dc.subject.meshBacteriaen
dc.subject.meshChlorhexidineen
dc.subject.meshHumansen
dc.subject.meshInfant, Newbornen
dc.subject.meshLipidsen
dc.subject.meshMolecular Sequence Dataen
dc.subject.meshProteomicsen
dc.subject.meshVernix Caseosaen
dc.titleVernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactionsen
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden.en
dc.identifier.journalCellular and molecular life sciences : CMLSen

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