The interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibilty-Reykjavik study

2.50
Hdl Handle:
http://hdl.handle.net/2336/54253
Title:
The interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibilty-Reykjavik study
Authors:
Eiriksdottir, G; Smith, A V; Aspelund, T; Hafsteinsdottir, S H; Olafsdottir, E; Launer, L J; Harris, T B; Gudnason, V
Citation:
Int J Obes (Lond). 2009, 33(2):267-72
Issue Date:
1-Feb-2009
Abstract:
OBJECTIVE: Common diseases often have an inflammatory component reflected by associated markers such as serum C-reactive protein (CRP) levels. Circulating CRP levels have also been associated with adipose tissue as well as with specific CRP genotypes. We examined the interaction between measures of body mass index (BMI), waist circumference and fat percent (total fat measured by bioimpedance) with genotypes of the CRP gene in the determination of CRP levels. METHODS: The first 2296 participants (mean age 76+/-6 years, 42% men) in the Age, Gene/Environment Susceptibility-Reykjavik Study, a multidisciplinary epidemiological study to determine risk factors in aging, were genotyped for 10 single nucleotide polymorphisms (SNPs) in the CRP gene. General linear models with age and terms for interaction of CRP genotypes with BMI, waist circumference and percent fat were used to evaluate the association of genotypes to CRP levels (high-sensitivity method, range 0-10 mg l(-1)) in men and women separately. RESULTS: We focused on the SNP rs1205 that represents the allele that captures the strongest effects of the gene on CRP levels. Carriers of the rs1205 G allele had significantly higher CRP levels than noncarriers in a dose-dependent manner. Compared to the AA genotype, the slope of the increase in CRP with increasing BMI (P=0.045) and waist circumference (P=0.014) was different for the G allele carriers and of similar magnitude in both men and women. The rs1205 interactions were not significant for fat mass percent, suggesting a possible association with fat localization. CONCLUSIONS: This study further illuminates the known association between measures of adiposity and CRP levels and is shown to be dependent on variation in the rs1205 SNP of the CRP gene. The correlated increase in CRP levels with adiposity is accentuated by presence of the G allele.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/ijo.2008.274

Full metadata record

DC FieldValue Language
dc.contributor.authorEiriksdottir, G-
dc.contributor.authorSmith, A V-
dc.contributor.authorAspelund, T-
dc.contributor.authorHafsteinsdottir, S H-
dc.contributor.authorOlafsdottir, E-
dc.contributor.authorLauner, L J-
dc.contributor.authorHarris, T B-
dc.contributor.authorGudnason, V-
dc.date.accessioned2009-03-11T13:35:11Z-
dc.date.available2009-03-11T13:35:11Z-
dc.date.issued2009-02-01-
dc.date.submitted2009-03-11-
dc.identifier.citationInt J Obes (Lond). 2009, 33(2):267-72en
dc.identifier.issn1476-5497-
dc.identifier.pmid19139754-
dc.identifier.doi10.1038/ijo.2008.274-
dc.identifier.urihttp://hdl.handle.net/2336/54253-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: Common diseases often have an inflammatory component reflected by associated markers such as serum C-reactive protein (CRP) levels. Circulating CRP levels have also been associated with adipose tissue as well as with specific CRP genotypes. We examined the interaction between measures of body mass index (BMI), waist circumference and fat percent (total fat measured by bioimpedance) with genotypes of the CRP gene in the determination of CRP levels. METHODS: The first 2296 participants (mean age 76+/-6 years, 42% men) in the Age, Gene/Environment Susceptibility-Reykjavik Study, a multidisciplinary epidemiological study to determine risk factors in aging, were genotyped for 10 single nucleotide polymorphisms (SNPs) in the CRP gene. General linear models with age and terms for interaction of CRP genotypes with BMI, waist circumference and percent fat were used to evaluate the association of genotypes to CRP levels (high-sensitivity method, range 0-10 mg l(-1)) in men and women separately. RESULTS: We focused on the SNP rs1205 that represents the allele that captures the strongest effects of the gene on CRP levels. Carriers of the rs1205 G allele had significantly higher CRP levels than noncarriers in a dose-dependent manner. Compared to the AA genotype, the slope of the increase in CRP with increasing BMI (P=0.045) and waist circumference (P=0.014) was different for the G allele carriers and of similar magnitude in both men and women. The rs1205 interactions were not significant for fat mass percent, suggesting a possible association with fat localization. CONCLUSIONS: This study further illuminates the known association between measures of adiposity and CRP levels and is shown to be dependent on variation in the rs1205 SNP of the CRP gene. The correlated increase in CRP levels with adiposity is accentuated by presence of the G allele.en
dc.language.isoenen
dc.publisherNature Pub. Groupen
dc.relation.urlhttp://dx.doi.org/10.1038/ijo.2008.274en
dc.subject.meshPubMed - in processen
dc.titleThe interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibilty-Reykjavik studyen
dc.typeArticleen
dc.contributor.departmentIcelandic Heart Association, Kopavogur, Iceland. gudny@hjarta.isen
dc.identifier.journalInternational journal of obesity (2005)en

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.