Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids.

1.00
Hdl Handle:
http://hdl.handle.net/2336/54513
Title:
Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids.
Authors:
Lönnerholm, G; Nordgren, A; Frost, B-M; Jonsson, O G; Kanerva, J; Nygaard, R; Schmiegelow, K; Larsson, R; Forestier, E
Citation:
Leukemia. 2009, 23(1):209-12
Issue Date:
1-Jan-2009
Abstract:
Dic(9;20)(p13;q11) was first described as a nonrandom chromosome abnormality in B-cell precursor acute lymphoblastic leukaemia (BCP ALL) in the mid 1990s,1, 2 and 71 dic(9;20)-positive cases have since then been reported.3, 4, 5 Approximately 90% of these cases were children or adolescents, with dic(9;20) occurring in about 2% of childhood BCP ALL.6 The recent review by Forestier et al.5 describes that dic(9;20)-leukaemias are of B-cell precursor immunophenotype, never have a high hyperdiploid modal number, show a female predominance, and have a significant age incidence peak at 3 years. Most patients are allocated to non-standard risk treatment arms due to high WBC (median 24 109/l) and a relatively high frequency of CNS disease or other extra-medullary leukaemia (EML) at diagnosis. The prognostic implications of dic(9;20) are to a large extent unknown. A relatively large proportion of the relapses reported in the literature have been extra-medullary, and post-relapse treatment including block therapy has been successful in several patients, as illustrated by a p-EFS of 0.62 and a predicted overall survival of 0.82 at 5 years for the 24 Nordic cases.5
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/leu.2008.179

Full metadata record

DC FieldValue Language
dc.contributor.authorLönnerholm, G-
dc.contributor.authorNordgren, A-
dc.contributor.authorFrost, B-M-
dc.contributor.authorJonsson, O G-
dc.contributor.authorKanerva, J-
dc.contributor.authorNygaard, R-
dc.contributor.authorSchmiegelow, K-
dc.contributor.authorLarsson, R-
dc.contributor.authorForestier, E-
dc.date.accessioned2009-03-12T09:45:07Z-
dc.date.available2009-03-12T09:45:07Z-
dc.date.issued2009-01-01-
dc.date.submitted2009-03-12-
dc.identifier.citationLeukemia. 2009, 23(1):209-12en
dc.identifier.issn1476-5551-
dc.identifier.pmid18615108-
dc.identifier.doi10.1038/leu.2008.179-
dc.identifier.urihttp://hdl.handle.net/2336/54513-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractDic(9;20)(p13;q11) was first described as a nonrandom chromosome abnormality in B-cell precursor acute lymphoblastic leukaemia (BCP ALL) in the mid 1990s,1, 2 and 71 dic(9;20)-positive cases have since then been reported.3, 4, 5 Approximately 90% of these cases were children or adolescents, with dic(9;20) occurring in about 2% of childhood BCP ALL.6 The recent review by Forestier et al.5 describes that dic(9;20)-leukaemias are of B-cell precursor immunophenotype, never have a high hyperdiploid modal number, show a female predominance, and have a significant age incidence peak at 3 years. Most patients are allocated to non-standard risk treatment arms due to high WBC (median 24 109/l) and a relatively high frequency of CNS disease or other extra-medullary leukaemia (EML) at diagnosis. The prognostic implications of dic(9;20) are to a large extent unknown. A relatively large proportion of the relapses reported in the literature have been extra-medullary, and post-relapse treatment including block therapy has been successful in several patients, as illustrated by a p-EFS of 0.62 and a predicted overall survival of 0.82 at 5 years for the 24 Nordic cases.5en
dc.language.isoenen
dc.publisherNature Publishing Group, Specialist Journalsen
dc.relation.urlhttp://dx.doi.org/10.1038/leu.2008.179en
dc.subject.meshAdolescenten
dc.subject.meshAdrenal Cortex Hormonesen
dc.subject.meshAsparaginaseen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshChromosome Aberrationsen
dc.subject.meshChromosomes, Human, Pair 20en
dc.subject.meshChromosomes, Human, Pair 9en
dc.subject.meshCytarabineen
dc.subject.meshDrug Resistance, Neoplasmen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphomaen
dc.titleDic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids.en
dc.typeArticleen
dc.identifier.journalLeukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.Ken

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