The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.

2.50
Hdl Handle:
http://hdl.handle.net/2336/56397
Title:
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.
Authors:
Helgadottir, Anna; Manolescu, Andrei; Thorleifsson, Gudmar; Gretarsdottir, Solveig; Jonsdottir, Helga; Thorsteinsdottir, Unnur; Samani, Nilesh J; Gudmundsson, Gudmundur; Grant, Struan F A; Thorgeirsson, Gudmundur; Sveinbjornsdottir, Sigurlaug; Valdimarsson, Einar M; Matthiasson, Stefan E; Johannsson, Halldor; Gudmundsdottir, Olof; Gurney, Mark E; Sainz, Jesus; Thorhallsdottir, Margret; Andresdottir, Margret; Frigge, Michael L; Topol, Eric J; Kong, Augustine; Gudnason, Vilmundur; Hakonarson, Hakon; Gulcher, Jeffrey R; Stefansson, Kari
Citation:
Nat. Genet. 2004, 36(3):233-9
Issue Date:
1-Mar-2004
Abstract:
We mapped a gene predisposing to myocardial infarction to a locus on chromosome 13q12-13. A four-marker single-nucleotide polymorphism (SNP) haplotype in this locus spanning the gene ALOX5AP encoding 5-lipoxygenase activating protein (FLAP) is associated with a two times greater risk of myocardial infarction in Iceland. This haplotype also confers almost two times greater risk of stroke. Another ALOX5AP haplotype is associated with myocardial infarction in individuals from the UK. Stimulated neutrophils from individuals with myocardial infarction produce more leukotriene B4, a key product in the 5-lipoxygenase pathway, than do neutrophils from controls, and this difference is largely attributed to cells from males who carry the at-risk haplotype. We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/ng1311

Full metadata record

DC FieldValue Language
dc.contributor.authorHelgadottir, Anna-
dc.contributor.authorManolescu, Andrei-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorGretarsdottir, Solveig-
dc.contributor.authorJonsdottir, Helga-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorSamani, Nilesh J-
dc.contributor.authorGudmundsson, Gudmundur-
dc.contributor.authorGrant, Struan F A-
dc.contributor.authorThorgeirsson, Gudmundur-
dc.contributor.authorSveinbjornsdottir, Sigurlaug-
dc.contributor.authorValdimarsson, Einar M-
dc.contributor.authorMatthiasson, Stefan E-
dc.contributor.authorJohannsson, Halldor-
dc.contributor.authorGudmundsdottir, Olof-
dc.contributor.authorGurney, Mark E-
dc.contributor.authorSainz, Jesus-
dc.contributor.authorThorhallsdottir, Margret-
dc.contributor.authorAndresdottir, Margret-
dc.contributor.authorFrigge, Michael L-
dc.contributor.authorTopol, Eric J-
dc.contributor.authorKong, Augustine-
dc.contributor.authorGudnason, Vilmundur-
dc.contributor.authorHakonarson, Hakon-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2009-03-19T10:54:46Z-
dc.date.available2009-03-19T10:54:46Z-
dc.date.issued2004-03-01-
dc.date.submitted2009-03-19-
dc.identifier.citationNat. Genet. 2004, 36(3):233-9en
dc.identifier.issn1061-4036-
dc.identifier.pmid14770184-
dc.identifier.doi10.1038/ng1311-
dc.identifier.urihttp://hdl.handle.net/2336/56397-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWe mapped a gene predisposing to myocardial infarction to a locus on chromosome 13q12-13. A four-marker single-nucleotide polymorphism (SNP) haplotype in this locus spanning the gene ALOX5AP encoding 5-lipoxygenase activating protein (FLAP) is associated with a two times greater risk of myocardial infarction in Iceland. This haplotype also confers almost two times greater risk of stroke. Another ALOX5AP haplotype is associated with myocardial infarction in individuals from the UK. Stimulated neutrophils from individuals with myocardial infarction produce more leukotriene B4, a key product in the 5-lipoxygenase pathway, than do neutrophils from controls, and this difference is largely attributed to cells from males who carry the at-risk haplotype. We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.en
dc.language.isoenen
dc.publisherNature Pub. Co.en
dc.relation.urlhttp://dx.doi.org/10.1038/ng1311en
dc.subject.meshCarrier Proteinsen
dc.subject.meshChromosome Mappingen
dc.subject.meshChromosomes, Human, Pair 13en
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHumansen
dc.subject.meshLeukotriene B4en
dc.subject.meshMembrane Proteinsen
dc.subject.meshMicrosatellite Repeatsen
dc.subject.meshMyocardial Infarctionen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshStrokeen
dc.titleThe gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.en
dc.typeArticleen
dc.contributor.departmentdeCODE genetics, Sturlugata 8, Reykjavik, Iceland.en
dc.identifier.journalNature geneticsen

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.