2.50
Hdl Handle:
http://hdl.handle.net/2336/56573
Title:
Second primary cancers among 109 000 cases of non-Hodgkin's lymphoma
Authors:
Brennan, P; Scélo, G; Hemminki, K; Mellemkjaer, L; Tracey, E; Andersen, A; Brewster, D H; Pukkala, E; McBride, M L; Kliewer, E V; Tonita, J M; Seow, A; Pompe-Kirn, V; Martos, C; Jonasson, J G; Colin, D; Boffetta, P
Citation:
Br. J. Cancer. 2005, 93(1):159-66
Issue Date:
11-Jul-2005
Abstract:
An analysis of other primary cancers in individuals with non-Hodgkin's lymphoma (NHL) can help to elucidate this cancer aetiology. In all, 109 451 first primary NHL were included in a pooled analysis of 13 cancer registries. The observed numbers of second cancers were compared to the expected numbers derived from the age-, sex-, calendar period- and registry-specific incidence rates. We also calculated the standardised incidence ratios for NHL as a second primary after other cancers. There was a 47% (95% confidence interval 43-51%) overall increase in the risk of a primary cancer after NHL. A strongly significant (P<0.001) increase was observed for cancers of the lip, tongue, oropharynx*, stomach, small intestine, colon*, liver, nasal cavity*, lung, soft tissues*, skin melanoma*, nonmelanoma skin*, bladder*, kidney*, thyroid*, Hodgkin's lymphoma*, lymphoid leukaemia* and myeloid leukaemia. Non-Hodgkin's lymphoma as a second primary was increased after cancers marked with an asterisk. Patterns of risk indicate a treatment effect for lung, bladder, stomach, Hodgkin's lymphoma and myeloid leukaemia. Common risk factors may be involved for cancers of the lung, bladder, nasal cavity and for soft tissues, such as pesticides. Bidirectional effects for several cancer sites of potential viral origin argue strongly for a role for immune suppression in NHL.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/sj.bjc.6602654

Full metadata record

DC FieldValue Language
dc.contributor.authorBrennan, P-
dc.contributor.authorScélo, G-
dc.contributor.authorHemminki, K-
dc.contributor.authorMellemkjaer, L-
dc.contributor.authorTracey, E-
dc.contributor.authorAndersen, A-
dc.contributor.authorBrewster, D H-
dc.contributor.authorPukkala, E-
dc.contributor.authorMcBride, M L-
dc.contributor.authorKliewer, E V-
dc.contributor.authorTonita, J M-
dc.contributor.authorSeow, A-
dc.contributor.authorPompe-Kirn, V-
dc.contributor.authorMartos, C-
dc.contributor.authorJonasson, J G-
dc.contributor.authorColin, D-
dc.contributor.authorBoffetta, P-
dc.date.accessioned2009-03-20T12:56:14Z-
dc.date.available2009-03-20T12:56:14Z-
dc.date.issued2005-07-11-
dc.date.submitted2009-03-20-
dc.identifier.citationBr. J. Cancer. 2005, 93(1):159-66en
dc.identifier.issn0007-0920-
dc.identifier.pmid15970927-
dc.identifier.doi10.1038/sj.bjc.6602654-
dc.identifier.urihttp://hdl.handle.net/2336/56573-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractAn analysis of other primary cancers in individuals with non-Hodgkin's lymphoma (NHL) can help to elucidate this cancer aetiology. In all, 109 451 first primary NHL were included in a pooled analysis of 13 cancer registries. The observed numbers of second cancers were compared to the expected numbers derived from the age-, sex-, calendar period- and registry-specific incidence rates. We also calculated the standardised incidence ratios for NHL as a second primary after other cancers. There was a 47% (95% confidence interval 43-51%) overall increase in the risk of a primary cancer after NHL. A strongly significant (P<0.001) increase was observed for cancers of the lip, tongue, oropharynx*, stomach, small intestine, colon*, liver, nasal cavity*, lung, soft tissues*, skin melanoma*, nonmelanoma skin*, bladder*, kidney*, thyroid*, Hodgkin's lymphoma*, lymphoid leukaemia* and myeloid leukaemia. Non-Hodgkin's lymphoma as a second primary was increased after cancers marked with an asterisk. Patterns of risk indicate a treatment effect for lung, bladder, stomach, Hodgkin's lymphoma and myeloid leukaemia. Common risk factors may be involved for cancers of the lung, bladder, nasal cavity and for soft tissues, such as pesticides. Bidirectional effects for several cancer sites of potential viral origin argue strongly for a role for immune suppression in NHL.en
dc.language.isoenen
dc.publisherNature Publishing Group on behalf of Cancer Research UKen
dc.relation.urlhttp://dx.doi.org/10.1038/sj.bjc.6602654en
dc.subject.meshAgeden
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshLymphoma, Non-Hodgkinen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshNeoplasms, Second Primaryen
dc.titleSecond primary cancers among 109 000 cases of non-Hodgkin's lymphomaen
dc.typeArticleen
dc.contributor.departmentInternational Agency for Research on Cancer, 69008 Lyon, France. brennan@iarc.fren
dc.identifier.journalBritish journal of canceren

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