DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia

2.50
Hdl Handle:
http://hdl.handle.net/2336/620558
Title:
DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia
Authors:
Borssén, Magnus; Nordlund, Jessica; Haider, Zahra; Landfors, Mattias; Larsson, Pär; Kanerva, Jukka; Schmiegelow, Kjeld; Flaegstad, Trond; Jónsson, Ólafur Gísli; Frost, Britt-Marie; Palle, Josefine; Forestier, Erik; Heyman, Mats; Hultdin, Magnus; Lönnerholm, Gudmar; Degerman, Sofie ( 0000-0002-2783-0712 )
Citation:
DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia 2018, 10 (1) Clinical Epigenetics
Issue Date:
5-Mar-2018
Abstract:
BACKGROUND: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients. METHODS: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data. RESULTS: Among the 137 patients that later relapsed, patients with a CIMP- profile (n = 42) at initial diagnosis had an inferior overall survival (pOS5years 33%) compared to CIMP+ patients (n = 95, pOS5years 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors. CONCLUSION: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.
Description:
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files
Additional Links:
https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-018-0466-3
Rights:
Archived with thanks to Clinical Epigenetics

Full metadata record

DC FieldValue Language
dc.contributor.authorBorssén, Magnusen
dc.contributor.authorNordlund, Jessicaen
dc.contributor.authorHaider, Zahraen
dc.contributor.authorLandfors, Mattiasen
dc.contributor.authorLarsson, Pären
dc.contributor.authorKanerva, Jukkaen
dc.contributor.authorSchmiegelow, Kjelden
dc.contributor.authorFlaegstad, Tronden
dc.contributor.authorJónsson, Ólafur Gíslien
dc.contributor.authorFrost, Britt-Marieen
dc.contributor.authorPalle, Josefineen
dc.contributor.authorForestier, Eriken
dc.contributor.authorHeyman, Matsen
dc.contributor.authorHultdin, Magnusen
dc.contributor.authorLönnerholm, Gudmaren
dc.contributor.authorDegerman, Sofieen
dc.date.accessioned2018-05-08T15:21:10Z-
dc.date.available2018-05-08T15:21:10Z-
dc.date.issued2018-03-05-
dc.date.submitted2018-
dc.identifier.citationDNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia 2018, 10 (1) Clinical Epigeneticsen
dc.identifier.issn1868-7075-
dc.identifier.issn1868-7083-
dc.identifier.doi10.1186/s13148-018-0466-3-
dc.identifier.urihttp://hdl.handle.net/2336/620558-
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Filesen
dc.description.abstractBACKGROUND: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients. METHODS: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data. RESULTS: Among the 137 patients that later relapsed, patients with a CIMP- profile (n = 42) at initial diagnosis had an inferior overall survival (pOS5years 33%) compared to CIMP+ patients (n = 95, pOS5years 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors. CONCLUSION: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.en
dc.description.sponsorshipSwedish Cancer Society Swedish Childhood Cancer Foundation Medical Faculty of Umea University Lion's Cancer Research Foundation Umea University Umea Pediatric Clinic Research Foundation Kempe foundations Magnus Bergvalls Foundation Uppsala-Umea Comprehensive Cancer Consortium Vasterbotten County Council Swedish Research Council Knut and Alice Wallenberg Foundationen
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttps://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-018-0466-3en
dc.rightsArchived with thanks to Clinical Epigeneticsen
dc.subjectHvítblæðien
dc.subjectBörnen
dc.subjectSjúkdómshorfuren
dc.subjectPED12en
dc.subject.meshDNA Methylationen
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphomaen
dc.subject.meshPrognosisen
dc.subject.meshChilden
dc.subject.meshMinorsen
dc.titleDNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemiaen
dc.typeArticleen
dc.contributor.department[ 1 ] Umea Univ, Dept Med Biosci, Blg 6M,2nd Floor, SE-90185 Umea, Sweden Show more [ 2 ] Uppsala Univ, Dept Med Sci, Uppsala, Sweden Show more [ 3 ] Uppsala Univ, Sci Life Lab, Uppsala, Sweden Show more [ 4 ] Univ Helsinki, Cent Hosp, Childrens Hosp, Helsinki, Finland Show more [ 5 ] Univ Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark Show more [ 6 ] Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark Show more [ 7 ] Univ Tromso, Dept Pediat, Tromso, Norway Show more [ 8 ] Univ Hosp North Norway, Tromso, Norway Show more [ 9 ] Landspitali Univ Hosp, Childrens Hosp, Pediat Hematol Oncol, Reykjavik, Iceland Show more [ 10 ] Uppsala Univ, Dept Womens & Childrens Hlth, Pediat, Uppsala, Sweden Show more [ 11 ] Karolinska Univ Hosp, Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Swedenen
dc.identifier.journalClinical Epigeneticsen
dc.rights.accessOpen Access - Opinn aðganguren
dc.departmentcodePED12-
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