Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers

2.50
Hdl Handle:
http://hdl.handle.net/2336/620594
Title:
Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers
Authors:
Erbas, Bircan; Knudsen, Toril Mørkve; Janson, Christer; Nilsen, Roy M.; Accordini, Simone; Benediktdottir, Bryndis; Dratva, Julia; Heinrich, Joachim; Jarvis, Debbie; Leynaert, Benedcite; Matheson, Melanie C.; Norbäck, Dan; Real, Francisco G.; Raherison-Semjen, Chantal; Villani, Simona; Dharmage, S.C.; Svanes, C.
Citation:
Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers 2018, 164:241 Environmental Research
Issue Date:
Jul-2018
Abstract:
BACKGROUND: Despite extensive knowledge of smoking effects on respiratory disease, there is no study including all age windows of exposure among ever smokers. The objective of this study was to assess the effects from smoking exposure in utero, early childhood, adolescence and adulthood on respiratory health outcomes in adult male and female ever smokers. METHODS: Respiratory health outcomes were assessed in 10,610 participants of the European Community Respiratory Health Survey (ECRHS) I who reported a history of ever smoking by questionnaire. The associations of maternal smoking in utero, maternal smoking during childhood, age of smoking debut and pack-years of smoking with respiratory symptoms, obstructive diseases and bronchial hyperreactivity were analysed using generalized linear regression, non-linearity between age of smoking debut and outcomes were assessed by Generalized additive mixed models. RESULTS: Respiratory symptoms and asthma were more frequent in adults if their mother smoked during pregnancy, and, in men, also if mother smoked in childhood. Wheeze and ≥3 respiratory symptoms declined with later smoking debut among women [≤10 years: OR = 3.51, 95% CI 1.26, 9.73; 11-12 years: 1.57[1.01-2.44]; 13-15 years: 1.11[0.94-1.32] and ≤10 years: 3.74[1.56-8.83]; 11-12 years: 1.76[1.19-2.56]; 13-15 years: 1.12[0.94-1.35], respectively]. Effects of increasing number of packyears were pronounced in women (Chronic Obstructive Pulmonary Disease (COPD): OR/10 packyears women: 1.33 [1.18, 1.50], men: 1.14 [1.04, 1.26] pinteraction = 0.01). CONCLUSIONS: Among ever smokers, smoking exposure in each stage of the lifespan show persistent harmful effects for adult respiratory health, while women appeared to be more vulnerable to an early age of smoking debut and amount of smoking in adulthood.
Description:
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S001393511830094X
Rights:
Archived with thanks to Environmental Research

Full metadata record

DC FieldValue Language
dc.contributor.authorErbas, Bircanen
dc.contributor.authorKnudsen, Toril Mørkveen
dc.contributor.authorJanson, Christeren
dc.contributor.authorNilsen, Roy M.en
dc.contributor.authorAccordini, Simoneen
dc.contributor.authorBenediktdottir, Bryndisen
dc.contributor.authorDratva, Juliaen
dc.contributor.authorHeinrich, Joachimen
dc.contributor.authorJarvis, Debbieen
dc.contributor.authorLeynaert, Benedciteen
dc.contributor.authorMatheson, Melanie C.en
dc.contributor.authorNorbäck, Danen
dc.contributor.authorReal, Francisco G.en
dc.contributor.authorRaherison-Semjen, Chantalen
dc.contributor.authorVillani, Simonaen
dc.contributor.authorDharmage, S.C.en
dc.contributor.authorSvanes, C.en
dc.date.accessioned2018-06-13T13:33:15Z-
dc.date.available2018-06-13T13:33:15Z-
dc.date.issued2018-07-
dc.date.submitted2018-
dc.identifier.citationCritical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers 2018, 164:241 Environmental Researchen
dc.identifier.issn00139351-
dc.identifier.doi10.1016/j.envres.2018.02.028-
dc.identifier.urihttp://hdl.handle.net/2336/620594-
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Filesen
dc.description.abstractBACKGROUND: Despite extensive knowledge of smoking effects on respiratory disease, there is no study including all age windows of exposure among ever smokers. The objective of this study was to assess the effects from smoking exposure in utero, early childhood, adolescence and adulthood on respiratory health outcomes in adult male and female ever smokers. METHODS: Respiratory health outcomes were assessed in 10,610 participants of the European Community Respiratory Health Survey (ECRHS) I who reported a history of ever smoking by questionnaire. The associations of maternal smoking in utero, maternal smoking during childhood, age of smoking debut and pack-years of smoking with respiratory symptoms, obstructive diseases and bronchial hyperreactivity were analysed using generalized linear regression, non-linearity between age of smoking debut and outcomes were assessed by Generalized additive mixed models. RESULTS: Respiratory symptoms and asthma were more frequent in adults if their mother smoked during pregnancy, and, in men, also if mother smoked in childhood. Wheeze and ≥3 respiratory symptoms declined with later smoking debut among women [≤10 years: OR = 3.51, 95% CI 1.26, 9.73; 11-12 years: 1.57[1.01-2.44]; 13-15 years: 1.11[0.94-1.32] and ≤10 years: 3.74[1.56-8.83]; 11-12 years: 1.76[1.19-2.56]; 13-15 years: 1.12[0.94-1.35], respectively]. Effects of increasing number of packyears were pronounced in women (Chronic Obstructive Pulmonary Disease (COPD): OR/10 packyears women: 1.33 [1.18, 1.50], men: 1.14 [1.04, 1.26] pinteraction = 0.01). CONCLUSIONS: Among ever smokers, smoking exposure in each stage of the lifespan show persistent harmful effects for adult respiratory health, while women appeared to be more vulnerable to an early age of smoking debut and amount of smoking in adulthood.en
dc.language.isoenen
dc.publisherAcademic Press Inc Elsevier Scienceen
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S001393511830094Xen
dc.rightsArchived with thanks to Environmental Researchen
dc.subjectReykingaren
dc.subjectÖndunarfærasjúkdómaren
dc.subjectAldurshóparen
dc.subjectPADen
dc.subject.meshTobacco Smokingen
dc.subject.meshAsthmaen
dc.subject.meshRespiratory Tract Diseasesen
dc.subject.meshAge Groupsen
dc.subject.meshYoung Adulten
dc.titleCritical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokersen
dc.typeArticleen
dc.contributor.department1 ] La Trobe Univ, Dept Publ Hlth, Melbourne, Vic, Australia Show more [ 2 ] Univ Bergen, Dept Clin Sci, Bergen, Norway [ 3 ] Uppsala Univ, Dept Med Sci Resp Allergy & Sleep Res, Uppsala, Sweden Show more [ 4 ] Haukeland Hosp, Ctr Clin Res, Bergen, Norway Show more [ 5 ] Univ Verona, Dept Publ Hlth & Community Med, Unit Epidemiol & Med Stat, Verona, Italy Show more [ 6 ] Univ Iceland, Landspitali Univ Hosp, Fac Med, Dept Resp Med & Sleep, Reykjavik, Iceland Show more [ 7 ] Swiss Trop & Publ Hlth Inst, Dept Publ Hlth & Epidemiol, Basel, Switzerland Show more [ 8 ] Helmholtz Zentrum, Inst Epidemiol 1, Munich, Germany Show more [ 9 ] Imperial Coll, Natl Heart & Lung Inst, Dept Resp Epidemiol Occupat Med & Publ Hlth, London, England Show more [ 10 ] INSERM, UMR1152, Team Epidemiol, Paris, France Show more [ 11 ] Univ Melbourne, Allergy & Lung Hlth Unit, Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia Show more [ 12 ] Uppsala Univ, Dept Med Sci, Uppsala, Sweden Show more [ 13 ] Bordeaux Univ, Inst Publ Hlth & Epidemiol, INSERM, U897, Bordeaux, France Show more [ 14 ] Univ Pavia, Dept Publ Hlth Expt & Forens Med, Unit Biostat & Clin Epidemiol, Pavia, Italy Show more [ 15 ] Univ Bergen, Ctr Int Hlth, Bergen, Norway Show more [ 16 ] Haukeland Hosp, Dept Occupat Med, Bergen, Norway Show more [ 17 ] Univ Basel, Basel, Switzerland Show more [ 18 ] Ludwig Maximilian Univ Munich, Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Inner City Clin, Munich, Germany Show more [ 19 ] Haukeland Hosp, Dept Gynecol & Obstet, Bergen, Norwayen
dc.identifier.journalEnvironmental Researchen
dc.rights.accessOpen Access - Opinn aðganguren
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