Associations of Quadriceps Torque Properties with Muscle Size, Attenuation, and Intramuscular Adipose Tissue in Older Adults

2.50
Hdl Handle:
http://hdl.handle.net/2336/620644
Title:
Associations of Quadriceps Torque Properties with Muscle Size, Attenuation, and Intramuscular Adipose Tissue in Older Adults
Authors:
Frank-Wilson, Andrew W ( 0000-0002-5486-239X ) ; Chalhoub, Didier; Figueiredo, Pedro; Jónsson, Pálmi V; Siggeirsdóttir, Kristín; Sigurdsson, Sigurdur; Eiriksdottir, Gudny; Guðnason, Vilmundur; Launer, Lenore; Harris, Tamara B
Citation:
Associations of Quadriceps Torque Properties with Muscle Size, Attenuation, and Intramuscular Adipose Tissue in Older Adults 2018, 73 (7):931 The Journals of Gerontology: Series A
Issue Date:
Jul-2018
Abstract:
BACKGROUND: Atrophy and fatty infiltration of muscle with aging are associated with fractures and falls, however, their direct associations with muscle function are not well described. It was hypothesized that participants with lower quadriceps muscle attenuation, area, and greater intramuscular adipose tissue (IMAT) will exhibit slower rates of torque development (RTD) and lower peak knee extension torques. METHODS: Data from 4,842 participants (2,041 men, 2,801 women) from the Age Gene/Environment Susceptibility Reykjavik Study (mean age 76 ± 0.1 years) with complete thigh computed tomography and isometric knee testing. Regression models were adjusted for health, behavior, and comorbidities. Muscle attenuation was further adjusted for muscle area and IMAT; muscle area adjusted for IMAT and attenuation; and IMAT adjusted for muscle area and attenuation. Standardized betas (β) indicate association effect sizes. RESULTS: In the fully-adjusted models, attenuation (men β = 0.06, 95% CI: 0.01, 0.11; women β = 0.07, 95% CI: 0.03, 0.11) and muscle area (men β = 0.13, 95% CI: 0.07, 0.19; women β = 0.10, 95% CI: 0.06, 0.15) were associated with knee RTD. Attenuation (men β = 0.12, 95% CI: 0.08, 0.16; women β = 0.12, 95% CI: 0.09, 0.16) and muscle area (men β = 0.38, 95% CI: 0.33, 0.43; women β = 0.33, 95% CI: 0.29, 0.37) were associated with peak torque. CONCLUSIONS: These data suggest that muscle attenuation and area are independently associated with RTD and peak torque; and that area and attenuation demonstrate similar contributions to RTD.
Description:
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Additional Links:
https://academic.oup.com/biomedgerontology/article/73/7/931/4803198
Rights:
Archived with thanks to The Journals of Gerontology: Series A

Full metadata record

DC FieldValue Language
dc.contributor.authorFrank-Wilson, Andrew Wen
dc.contributor.authorChalhoub, Didieren
dc.contributor.authorFigueiredo, Pedroen
dc.contributor.authorJónsson, Pálmi Ven
dc.contributor.authorSiggeirsdóttir, Kristínen
dc.contributor.authorSigurdsson, Sigurduren
dc.contributor.authorEiriksdottir, Gudnyen
dc.contributor.authorGuðnason, Vilmunduren
dc.contributor.authorLauner, Lenoreen
dc.contributor.authorHarris, Tamara Ben
dc.date.accessioned2018-07-06T15:33:37Z-
dc.date.available2018-07-06T15:33:37Z-
dc.date.issued2018-07-
dc.date.submitted2018-
dc.identifier.citationAssociations of Quadriceps Torque Properties with Muscle Size, Attenuation, and Intramuscular Adipose Tissue in Older Adults 2018, 73 (7):931 The Journals of Gerontology: Series Aen
dc.identifier.issn1079-5006-
dc.identifier.issn1758-535X-
dc.identifier.doi10.1093/gerona/glx262-
dc.identifier.urihttp://hdl.handle.net/2336/620644-
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen
dc.description.abstractBACKGROUND: Atrophy and fatty infiltration of muscle with aging are associated with fractures and falls, however, their direct associations with muscle function are not well described. It was hypothesized that participants with lower quadriceps muscle attenuation, area, and greater intramuscular adipose tissue (IMAT) will exhibit slower rates of torque development (RTD) and lower peak knee extension torques. METHODS: Data from 4,842 participants (2,041 men, 2,801 women) from the Age Gene/Environment Susceptibility Reykjavik Study (mean age 76 ± 0.1 years) with complete thigh computed tomography and isometric knee testing. Regression models were adjusted for health, behavior, and comorbidities. Muscle attenuation was further adjusted for muscle area and IMAT; muscle area adjusted for IMAT and attenuation; and IMAT adjusted for muscle area and attenuation. Standardized betas (β) indicate association effect sizes. RESULTS: In the fully-adjusted models, attenuation (men β = 0.06, 95% CI: 0.01, 0.11; women β = 0.07, 95% CI: 0.03, 0.11) and muscle area (men β = 0.13, 95% CI: 0.07, 0.19; women β = 0.10, 95% CI: 0.06, 0.15) were associated with knee RTD. Attenuation (men β = 0.12, 95% CI: 0.08, 0.16; women β = 0.12, 95% CI: 0.09, 0.16) and muscle area (men β = 0.38, 95% CI: 0.33, 0.43; women β = 0.33, 95% CI: 0.29, 0.37) were associated with peak torque. CONCLUSIONS: These data suggest that muscle attenuation and area are independently associated with RTD and peak torque; and that area and attenuation demonstrate similar contributions to RTD.en
dc.description.sponsorshipNational Institutes of Health National Institute on Aging Intramural Research Program Hjartavernd (the Icelandic Heart Association) Althingi (the Icelandic Parliament)en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urlhttps://academic.oup.com/biomedgerontology/article/73/7/931/4803198en
dc.rightsArchived with thanks to The Journals of Gerontology: Series Aen
dc.subjectVöðvavisnunen
dc.subjectAldraðiren
dc.subjectBeinbroten
dc.subjectDettnien
dc.subjectBylturen
dc.subjectGER12en
dc.subject.meshSubcutaneous Faten
dc.subject.meshMuscle, Skeletalen
dc.subject.meshTorqueen
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAccidental Fallsen
dc.subject.meshFractures, Boneen
dc.titleAssociations of Quadriceps Torque Properties with Muscle Size, Attenuation, and Intramuscular Adipose Tissue in Older Adultsen
dc.typeArticleen
dc.contributor.department[ 1 ] NIA, Lab Epidemiol & Populat Sci, Bethesda, MD 20892 USA Show more [ 2 ] Univ Saskatchewan, Coll Kinesiol, Saskatoon, SK, Canada [ 3 ] Univ Inst Maia, ISMAI, CIDESD, Res Ctr Sports Sci Hlth Sci & Human Dev, Porto, Portugal Show more [ 4 ] Landspitali Univ Hosp, Dept Geriatr, Reykjavik, Iceland Show more [ 5 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 6 ] Iceland Heart Assoc Res Inst, Reykjavik, Icelanden
dc.identifier.journalThe Journals of Gerontology: Series Aen
dc.rights.accessOpen Access - Opinn aðganguren
dc.contributor.institutionLaboratory of Epidemiology and Population Science, National Institute on Aging (NIA), Bethesda, Maryland-
dc.contributor.institutionLaboratory of Epidemiology and Population Science, National Institute on Aging (NIA), Bethesda, Maryland-
dc.contributor.institutionLaboratory of Epidemiology and Population Science, National Institute on Aging (NIA), Bethesda, Maryland-
dc.contributor.institutionDepartment of Geriatrics, Landspítali University Hospital, Reykjavik, Iceland-
dc.contributor.institutionIcelandic Heart Association Research Institute, Reykjavik, Iceland-
dc.contributor.institutionIcelandic Heart Association Research Institute, Reykjavik, Iceland-
dc.contributor.institutionIcelandic Heart Association Research Institute, Reykjavik, Iceland-
dc.contributor.institutionFaculty of Medicine, University of Iceland, Reykjavik-
dc.contributor.institutionLaboratory of Epidemiology and Population Science, National Institute on Aging (NIA), Bethesda, Maryland-
dc.contributor.institutionLaboratory of Epidemiology and Population Science, National Institute on Aging (NIA), Bethesda, Maryland-
dc.departmentcodeGER12-
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