The effects of repetitive transcranial magnetic stimulation on depressive symptoms and the P(300) event-related potential

2.50
Hdl Handle:
http://hdl.handle.net/2336/6345
Title:
The effects of repetitive transcranial magnetic stimulation on depressive symptoms and the P(300) event-related potential
Authors:
Moller, Anna L; Hjaltason, Omar; Ivarsson, Omar; Stefansson, Sigurjon B
Citation:
Nord J Psychiatry 2006, 60(4):282-5
Issue Date:
1-Aug-2006
Abstract:
Changes in the Hamilton Depression Rating Scale and the P(300) auditory event-related potential were assessed in 10 patients with depression before and after a treatment course of five daily sessions of 10 Hz repetitive transcranial magnetic stimulation (rTMS) over the left prefrontal cortex. The patients were initially randomly allocated either to an active or a placebo rTMS treatment. All patients received both types of treatment separated by an interval of 4 weeks. The median Hamilton score decreased by 7 points following active rTMS and by 1 point after sham (p=0.075). Active rTMS was associated with a significant increase in the P(300) amplitude compared with sham (p=0.02). There was no correlation between changes in P(300) measurements and the Hamilton scores after active treatment. We conclude that five daily sessions of left prefrontal rTMS treatment is not of sufficient duration to make a significant improvement in depressive symptoms.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field
Additional Links:
http://dx.doi.org/10.1080/08039480600790119

Full metadata record

DC FieldValue Language
dc.contributor.authorMoller, Anna L-
dc.contributor.authorHjaltason, Omar-
dc.contributor.authorIvarsson, Omar-
dc.contributor.authorStefansson, Sigurjon B-
dc.date.accessioned2006-12-04T13:35:16Z-
dc.date.available2006-12-04T13:35:16Z-
dc.date.issued2006-08-01-
dc.date.submitted2006-12-04-
dc.identifier.citationNord J Psychiatry 2006, 60(4):282-5en
dc.identifier.issn0803-9488-
dc.identifier.pmid16923636-
dc.identifier.doi10.1080/08039480600790119-
dc.identifier.otherPSY12-
dc.identifier.otherNEU12-
dc.identifier.urihttp://hdl.handle.net/2336/6345-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Link fielden
dc.description.abstractChanges in the Hamilton Depression Rating Scale and the P(300) auditory event-related potential were assessed in 10 patients with depression before and after a treatment course of five daily sessions of 10 Hz repetitive transcranial magnetic stimulation (rTMS) over the left prefrontal cortex. The patients were initially randomly allocated either to an active or a placebo rTMS treatment. All patients received both types of treatment separated by an interval of 4 weeks. The median Hamilton score decreased by 7 points following active rTMS and by 1 point after sham (p=0.075). Active rTMS was associated with a significant increase in the P(300) amplitude compared with sham (p=0.02). There was no correlation between changes in P(300) measurements and the Hamilton scores after active treatment. We conclude that five daily sessions of left prefrontal rTMS treatment is not of sufficient duration to make a significant improvement in depressive symptoms.en
dc.language.isoenen
dc.publisherTaylor & Francis Health Sciencesen
dc.relation.urlhttp://dx.doi.org/10.1080/08039480600790119en
dc.subject.meshDepressionen
dc.subject.meshTranscranial Magnetic Stimulationen
dc.subject.meshAdulten
dc.subject.meshIcelanden
dc.subject.meshPsychiatric Status Rating Scalesen
dc.subject.meshDepressive Disorderen
dc.subject.meshTreatment Outcomeen
dc.subject.meshPlacebosen
dc.subject.meshCross-Over Studiesen
dc.subject.meshTranscranial Magnetic Stimulationen
dc.titleThe effects of repetitive transcranial magnetic stimulation on depressive symptoms and the P(300) event-related potentialen
dc.typeArticleen
dc.identifier.journalNordic journal of psychiatryen
dc.format.digYES-

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