The effects of adrenocorticotrophic hormone and an equivalent dose of cortisol on the serum concentrations of lipids, lipoproteins, and apolipoproteins

2.50
Hdl Handle:
http://hdl.handle.net/2336/6347
Title:
The effects of adrenocorticotrophic hormone and an equivalent dose of cortisol on the serum concentrations of lipids, lipoproteins, and apolipoproteins
Authors:
Berg, Anna-Lena; Rafnsson, Arnar Thor; Johannsson, Magnus; Dallongeville, Jean; Arnadottir, Margret
Citation:
Metab. Clin. Exp. 2006, 55(8):1083-7
Issue Date:
1-Aug-2006
Abstract:
Previous studies have shown a strong lipid-lowering effect of adrenocorticotrophic hormone (ACTH) in healthy individuals and in patients with different kinds of dyslipoproteinemia. The mechanism behind this effect has not been established and its direct ACTH-specific nature has been questioned. Therefore, the present study was performed. Thirty healthy young males were randomized into 3 groups of equal size: one group received ACTH1-24 1 mg IM, daily for 4 days, another group was treated with cortisol 150 mg ID (50 mg tid) daily for 4 days, whereas a control group was observed for 4 days. Fasting blood samples were collected before and after treatment or observation. The serum concentrations of cholesterol (12%, P < .05), low-density lipoprotein cholesterol (24%, P < .01), and apolipoprotein (apo) B (31%, P < .01) decreased significantly in the ACTH group but not in the cortisol and control groups. The statistical workup confirmed that only ACTH had a lowering effect on the apo B-containing lipoproteins. In contrast, the results indicated conformity between the treatment groups with respect to increases in the serum apo E concentrations. There were inconsistent changes in the serum concentrations of the triglycerides, high-density lipoprotein cholesterol, apo A, and lipoprotein(a). The main results were clear: the lowering effect of ACTH on the serum concentration of apo B-containing lipoproteins could not be ascribed to cortisol. These, in combination with previous in vitro results, indicated an ACTH-specific effect.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1016/j.metabol.2006.04.001

Full metadata record

DC FieldValue Language
dc.contributor.authorBerg, Anna-Lena-
dc.contributor.authorRafnsson, Arnar Thor-
dc.contributor.authorJohannsson, Magnus-
dc.contributor.authorDallongeville, Jean-
dc.contributor.authorArnadottir, Margret-
dc.date.accessioned2006-12-04T16:31:33Z-
dc.date.available2006-12-04T16:31:33Z-
dc.date.issued2006-08-01-
dc.date.submitted2006-12-04-
dc.identifier.citationMetab. Clin. Exp. 2006, 55(8):1083-7en
dc.identifier.issn0026-0495-
dc.identifier.pmid16839845-
dc.identifier.doi10.1016/j.metabol.2006.04.001-
dc.identifier.otherNEP12-
dc.identifier.urihttp://hdl.handle.net/2336/6347-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPrevious studies have shown a strong lipid-lowering effect of adrenocorticotrophic hormone (ACTH) in healthy individuals and in patients with different kinds of dyslipoproteinemia. The mechanism behind this effect has not been established and its direct ACTH-specific nature has been questioned. Therefore, the present study was performed. Thirty healthy young males were randomized into 3 groups of equal size: one group received ACTH1-24 1 mg IM, daily for 4 days, another group was treated with cortisol 150 mg ID (50 mg tid) daily for 4 days, whereas a control group was observed for 4 days. Fasting blood samples were collected before and after treatment or observation. The serum concentrations of cholesterol (12%, P < .05), low-density lipoprotein cholesterol (24%, P < .01), and apolipoprotein (apo) B (31%, P < .01) decreased significantly in the ACTH group but not in the cortisol and control groups. The statistical workup confirmed that only ACTH had a lowering effect on the apo B-containing lipoproteins. In contrast, the results indicated conformity between the treatment groups with respect to increases in the serum apo E concentrations. There were inconsistent changes in the serum concentrations of the triglycerides, high-density lipoprotein cholesterol, apo A, and lipoprotein(a). The main results were clear: the lowering effect of ACTH on the serum concentration of apo B-containing lipoproteins could not be ascribed to cortisol. These, in combination with previous in vitro results, indicated an ACTH-specific effect.en
dc.language.isoenen
dc.publisherW.B. Saundersen
dc.relation.urlhttp://dx.doi.org/10.1016/j.metabol.2006.04.001en
dc.subject.meshAdulten
dc.subject.meshAlbuminsen
dc.subject.meshAntilipemic Agentsen
dc.subject.meshApolipoproteinsen
dc.subject.meshApolipoproteins Aen
dc.subject.meshApolipoproteins Ben
dc.subject.meshBody Weighten
dc.subject.meshCholesterolen
dc.subject.meshCorticotropinen
dc.subject.meshDexamethasoneen
dc.subject.meshDose-Response Relationship, Drugen
dc.subject.meshHumansen
dc.subject.meshHydrocortisoneen
dc.subject.meshLipidsen
dc.subject.meshLipoproteinsen
dc.subject.meshTriglyceridesen
dc.titleThe effects of adrenocorticotrophic hormone and an equivalent dose of cortisol on the serum concentrations of lipids, lipoproteins, and apolipoproteinsen
dc.typeArticleen
dc.identifier.journalMetabolism: clinical and experimentalen
dc.format.digYES-

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