2.50
Hdl Handle:
http://hdl.handle.net/2336/6352
Title:
Neisseria meningitidis sequence type and risk for death, Iceland
Authors:
Gottfredsson, Magnus; Diggle, Mathew A; Lawrie, David I; Erlensdóttir, Helga; Hardardottir, Hjordis; Kristinsson, Karl G; Clarke, Stuart c
Citation:
Emerging Infect. Dis. 2006, 12(7):1066-73
Issue Date:
1-Jul-2006
Abstract:
Invasive meningococcal infections are hyperendemic in Iceland, a relatively isolated country in the mid-Atlantic. We performed a nationwide study on all viable meningococcal strains (N = 362) from 1977 to 2004. We analyzed the association of patient's age and sex, meningococcal serogroups, and sequence types (STs) with outcomes. Overall, 59 different STs were identified, 19 of which were unique to Iceland. The most common STs were 32 (24.6%), 11 (19.9%), and 10 (10.2%). The unique ST-3492 ranked fourth (7.7%). The most common serogroups were B (56.4%), C (39.8%), and A (2.2%). Age (p < 0.001) and infection with a unique ST (p = 0.011) were independently associated with increased death rates, whereas isolation of meningococci from cerebrospinal fluid only was associated with lower death rates (p = 0.046). This study shows evolutionary trends of meningococcal isolates in a relatively isolated community and highlights an association between unique STs and poor outcome.
Description:
To access Publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.cdc.gov/ncidod/eid/vol12no07/05-1624.htm

Full metadata record

DC FieldValue Language
dc.contributor.authorGottfredsson, Magnus-
dc.contributor.authorDiggle, Mathew A-
dc.contributor.authorLawrie, David I-
dc.contributor.authorErlensdóttir, Helga-
dc.contributor.authorHardardottir, Hjordis-
dc.contributor.authorKristinsson, Karl G-
dc.contributor.authorClarke, Stuart c-
dc.date.accessioned2006-12-05T09:46:35Z-
dc.date.available2006-12-05T09:46:35Z-
dc.date.issued2006-07-01-
dc.date.submitted2006-12-05-
dc.identifier.citationEmerging Infect. Dis. 2006, 12(7):1066-73en
dc.identifier.issn1080-6040-
dc.identifier.pmid16836822-
dc.identifier.otherTMD12-
dc.identifier.otherBAC12-
dc.identifier.urihttp://hdl.handle.net/2336/6352-
dc.descriptionTo access Publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractInvasive meningococcal infections are hyperendemic in Iceland, a relatively isolated country in the mid-Atlantic. We performed a nationwide study on all viable meningococcal strains (N = 362) from 1977 to 2004. We analyzed the association of patient's age and sex, meningococcal serogroups, and sequence types (STs) with outcomes. Overall, 59 different STs were identified, 19 of which were unique to Iceland. The most common STs were 32 (24.6%), 11 (19.9%), and 10 (10.2%). The unique ST-3492 ranked fourth (7.7%). The most common serogroups were B (56.4%), C (39.8%), and A (2.2%). Age (p < 0.001) and infection with a unique ST (p = 0.011) were independently associated with increased death rates, whereas isolation of meningococci from cerebrospinal fluid only was associated with lower death rates (p = 0.046). This study shows evolutionary trends of meningococcal isolates in a relatively isolated community and highlights an association between unique STs and poor outcome.en
dc.language.isoenen
dc.publisherNational Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC),en
dc.relation.urlhttp://www.cdc.gov/ncidod/eid/vol12no07/05-1624.htmen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAgingen
dc.subject.meshAnti-Bacterial Agentsen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshDrug Resistance, Bacterialen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIceland/epidemiologyen
dc.subject.meshInfanten
dc.subject.meshLongitudinal Studiesen
dc.subject.meshMaleen
dc.subject.meshMeningococcal Infectionsen
dc.subject.meshNeisseria meningitidisen
dc.subject.meshPhylogenyen
dc.subject.meshRisk Factorsen
dc.titleNeisseria meningitidis sequence type and risk for death, Icelanden
dc.typeArticleen
dc.identifier.journalEmerging infectious diseasesen
dc.format.digYES-

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