A common variant associated with prostate cancer in European and African populations

2.50
Hdl Handle:
http://hdl.handle.net/2336/6357
Title:
A common variant associated with prostate cancer in European and African populations
Authors:
Amundadottir, Laufey T; Sulem, Patrick; Gudmundsson, Julius; Helgason, Agnar; Baker, Adam; Agnarsson, Bjarni A; Sigurdsson, Asgeir; Benediktsdottir, Kristrun R; Cazier, Jean-Baptiste; Sainz, Jesus; Jakobsdottir, Margret; Kostic, Jelena; Magnusdottir, Droplaug N; Ghosh, Shyamali; Agnarsson, Kari; Birgisdottir, Birgitta; Le Roux, Louise; Olafsdottir, Adalheidur; Blondal, Thorarinn; Andresdottir, Margret; Gretarsdottir, Olafia Svandis; Bergthorsson, Jon T; Gudbjartsson, Daniel; Gylfason, Arnaldur; Thorleifsson, Gudmar; Manolescu, Andrei; Kristjansson, Kristleifur; Geirsson, Gudmundur; Isaksson, Helgi; Douglas, Julie; Johansson, Jan-Erik; Bälter, Katarina; Wiklund, Fredrik; Montie, James E; Yu, Xiaoying; Suarez, Brian K; Ober, Carole; Cooney, Kathleen A; Gronberg, Henrik; Catalona, William J; Einarsson, Gudmundur V; Barkardottir, Rosa B; Gulcher, Jeffrey R; Kong, Augustine; Thorsteinsdottir, Unnur; Stefansson, Kari
Citation:
Nat. Genet. 2006, 38(6):652-8
Issue Date:
1-Jun-2006
Abstract:
With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.nature.com/ng/journal/v38/n6/full/ng1808.html

Full metadata record

DC FieldValue Language
dc.contributor.authorAmundadottir, Laufey T-
dc.contributor.authorSulem, Patrick-
dc.contributor.authorGudmundsson, Julius-
dc.contributor.authorHelgason, Agnar-
dc.contributor.authorBaker, Adam-
dc.contributor.authorAgnarsson, Bjarni A-
dc.contributor.authorSigurdsson, Asgeir-
dc.contributor.authorBenediktsdottir, Kristrun R-
dc.contributor.authorCazier, Jean-Baptiste-
dc.contributor.authorSainz, Jesus-
dc.contributor.authorJakobsdottir, Margret-
dc.contributor.authorKostic, Jelena-
dc.contributor.authorMagnusdottir, Droplaug N-
dc.contributor.authorGhosh, Shyamali-
dc.contributor.authorAgnarsson, Kari-
dc.contributor.authorBirgisdottir, Birgitta-
dc.contributor.authorLe Roux, Louise-
dc.contributor.authorOlafsdottir, Adalheidur-
dc.contributor.authorBlondal, Thorarinn-
dc.contributor.authorAndresdottir, Margret-
dc.contributor.authorGretarsdottir, Olafia Svandis-
dc.contributor.authorBergthorsson, Jon T-
dc.contributor.authorGudbjartsson, Daniel-
dc.contributor.authorGylfason, Arnaldur-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorManolescu, Andrei-
dc.contributor.authorKristjansson, Kristleifur-
dc.contributor.authorGeirsson, Gudmundur-
dc.contributor.authorIsaksson, Helgi-
dc.contributor.authorDouglas, Julie-
dc.contributor.authorJohansson, Jan-Erik-
dc.contributor.authorBälter, Katarina-
dc.contributor.authorWiklund, Fredrik-
dc.contributor.authorMontie, James E-
dc.contributor.authorYu, Xiaoying-
dc.contributor.authorSuarez, Brian K-
dc.contributor.authorOber, Carole-
dc.contributor.authorCooney, Kathleen A-
dc.contributor.authorGronberg, Henrik-
dc.contributor.authorCatalona, William J-
dc.contributor.authorEinarsson, Gudmundur V-
dc.contributor.authorBarkardottir, Rosa B-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorKong, Augustine-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2006-12-05T16:24:49Z-
dc.date.available2006-12-05T16:24:49Z-
dc.date.issued2006-06-01-
dc.date.submitted2006-12-05-
dc.identifier.citationNat. Genet. 2006, 38(6):652-8en
dc.identifier.issn1061-4036-
dc.identifier.pmid16682969-
dc.identifier.doi10.1038/ng1808-
dc.identifier.otherPTT12-
dc.identifier.otherURO12-
dc.identifier.urihttp://hdl.handle.net/2336/6357-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWith the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.en
dc.language.isoenen
dc.publisherNature Pub. Co.en
dc.relation.urlhttp://www.nature.com/ng/journal/v38/n6/full/ng1808.htmlen
dc.subject.meshAfrican Continental Ancestry Groupen
dc.subject.meshAllelesen
dc.subject.meshEuropean Continental Ancestry Groupen
dc.subject.meshMaleen
dc.subject.meshMicrosatellite Repeatsen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshProstatic Neoplasmsen
dc.subject.meshResearch Support, N.I.H., Extramuralen
dc.subject.meshResearch Support, Non-U.S. Gov'ten
dc.titleA common variant associated with prostate cancer in European and African populationsen
dc.typeArticleen
dc.format.digYES-

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