Dynamics of pneumococcal carriage among healthy Icelandic children attending day-care centres

2.50
Hdl Handle:
http://hdl.handle.net/2336/64353
Title:
Dynamics of pneumococcal carriage among healthy Icelandic children attending day-care centres
Authors:
Tomasson, Gunnar; Gudnason, Thorolfur; Kristinsson, Karl G
Citation:
Scand. J. Infect. Dis. 2005, 37(6-7):422-8
Issue Date:
1-Jul-2005
Abstract:
Invasive pneumococcal disease and antimicrobial (AM) resistance in pneumococci are important public health concerns. With the advent of new pneumococcal vaccines, information on serotype prevalence and their temporal fluctuations is important. Information on AM use and consent for participation was obtained by a questionnaire to parents of children at 5 day-care centres in Reykjavik from 1992 to 1999, and nasopharyngeal swabs were cultured selectively for pneumococci. The pneumococci were serotyped and pulsed field gel electrophoresis used to determine clonality. Of 1228 nasopharyngeal swabs, 640 (52.1%) yielded pneumococci of which 89 (13.9%) had decreased susceptibility to penicillin and 1 was resistant. Children receiving AMs during the month preceding nasopharyngeal sampling and children attending a day-care centre where AM use was high were significantly more likely to carry penicillin non-susceptible isolates. Serotypes 6A, 6B and 23F were most common (48%), and 74% of serotyped isolates belonged to 1 of the 7 most common serotypes. Almost all penicillin non-susceptible isolates were of serotype 6B or 19A. Serotype prevalence fluctuated markedly between y. In conclusion, there was significant variation in serotype prevalence between y, and only 51% of the pneumococci belonged to serotypes covered by the current 7-valent conjugated vaccine.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.informaworld.com/10.1080/00365540510035346

Full metadata record

DC FieldValue Language
dc.contributor.authorTomasson, Gunnar-
dc.contributor.authorGudnason, Thorolfur-
dc.contributor.authorKristinsson, Karl G-
dc.date.accessioned2009-04-03T15:03:49Z-
dc.date.available2009-04-03T15:03:49Z-
dc.date.issued2005-07-01-
dc.date.submitted2009-03-03-
dc.identifier.citationScand. J. Infect. Dis. 2005, 37(6-7):422-8en
dc.identifier.issn0036-5548-
dc.identifier.pmid16012001-
dc.identifier.doi10.1080/00365540510035346-
dc.identifier.urihttp://hdl.handle.net/2336/64353-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractInvasive pneumococcal disease and antimicrobial (AM) resistance in pneumococci are important public health concerns. With the advent of new pneumococcal vaccines, information on serotype prevalence and their temporal fluctuations is important. Information on AM use and consent for participation was obtained by a questionnaire to parents of children at 5 day-care centres in Reykjavik from 1992 to 1999, and nasopharyngeal swabs were cultured selectively for pneumococci. The pneumococci were serotyped and pulsed field gel electrophoresis used to determine clonality. Of 1228 nasopharyngeal swabs, 640 (52.1%) yielded pneumococci of which 89 (13.9%) had decreased susceptibility to penicillin and 1 was resistant. Children receiving AMs during the month preceding nasopharyngeal sampling and children attending a day-care centre where AM use was high were significantly more likely to carry penicillin non-susceptible isolates. Serotypes 6A, 6B and 23F were most common (48%), and 74% of serotyped isolates belonged to 1 of the 7 most common serotypes. Almost all penicillin non-susceptible isolates were of serotype 6B or 19A. Serotype prevalence fluctuated markedly between y. In conclusion, there was significant variation in serotype prevalence between y, and only 51% of the pneumococci belonged to serotypes covered by the current 7-valent conjugated vaccine.en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urlhttp://www.informaworld.com/10.1080/00365540510035346en
dc.subject.meshAnti-Bacterial Agentsen
dc.subject.meshCarrier Stateen
dc.subject.meshChilden
dc.subject.meshChild Day Care Centersen
dc.subject.meshChild, Preschoolen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshInfanten
dc.subject.meshPenicillin Resistanceen
dc.subject.meshPneumococcal Infectionsen
dc.subject.meshRisk Factorsen
dc.subject.meshStreptococcus pneumoniaeen
dc.subject.meshTime Factorsen
dc.titleDynamics of pneumococcal carriage among healthy Icelandic children attending day-care centresen
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Microbiology, Landspitali University Hospital, Reykjavik, Iceland.en
dc.identifier.journalScandinavian journal of infectious diseasesen

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