Synovial concentrations of the angiogenic peptides bFGF and VEGF do not discriminate rheumatoid arthritis from other forms of inflammatory arthritis

2.50
Hdl Handle:
http://hdl.handle.net/2336/64501
Title:
Synovial concentrations of the angiogenic peptides bFGF and VEGF do not discriminate rheumatoid arthritis from other forms of inflammatory arthritis
Authors:
Gudbjornsson, B; Christofferson, R; Larsson, A
Citation:
Scand. J. Clin. Lab. Invest. 2004, 64(1):9-15
Issue Date:
1-Feb-2004
Abstract:
OBJECTIVES: To investigate whether concentrations of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) in aspirated synovial fluid can be used to distinguish rheumatoid arthritis from other forms of inflammatory arthritis. METHODS: bFGF and VEGF concentrations were measured in aspirated synovial fluid and serum samples from 66 patients with active arthritis (clinical diagnoses: rheumatoid arthritis (35 patients), psoriatic arthritis (9), reactive arthritis (11) and arthritis UNS (11)) utilizing commercial ELISA kits. RESULTS: In comparison with controls, elevated concentrations of VEGF were found in synovial fluid compared with in serum in all forms of arthritis. There were no significant differences in synovial fluid bFGF or VEGF concentrations between rheumatoid arthritis and the other forms of inflammatory arthritis. CONCLUSION: Both serum bFGF and VEGF concentrations were increased in patients with rheumatoid arthritis. Patients treated with steroids had lower synovial fluid bFGF concentrations. Synovial fluid levels of bFGF and VEGF were elevated but could not be used to distinguish rheumatoid arthritis from other forms of inflammatory arthritis.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1080/00365510410003732

Full metadata record

DC FieldValue Language
dc.contributor.authorGudbjornsson, B-
dc.contributor.authorChristofferson, R-
dc.contributor.authorLarsson, A-
dc.date.accessioned2009-04-06T15:43:22Z-
dc.date.available2009-04-06T15:43:22Z-
dc.date.issued2004-02-01-
dc.date.submitted2009-04-06-
dc.identifier.citationScand. J. Clin. Lab. Invest. 2004, 64(1):9-15en
dc.identifier.issn0036-5513-
dc.identifier.pmid15025424-
dc.identifier.urihttp://hdl.handle.net/2336/64501-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVES: To investigate whether concentrations of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) in aspirated synovial fluid can be used to distinguish rheumatoid arthritis from other forms of inflammatory arthritis. METHODS: bFGF and VEGF concentrations were measured in aspirated synovial fluid and serum samples from 66 patients with active arthritis (clinical diagnoses: rheumatoid arthritis (35 patients), psoriatic arthritis (9), reactive arthritis (11) and arthritis UNS (11)) utilizing commercial ELISA kits. RESULTS: In comparison with controls, elevated concentrations of VEGF were found in synovial fluid compared with in serum in all forms of arthritis. There were no significant differences in synovial fluid bFGF or VEGF concentrations between rheumatoid arthritis and the other forms of inflammatory arthritis. CONCLUSION: Both serum bFGF and VEGF concentrations were increased in patients with rheumatoid arthritis. Patients treated with steroids had lower synovial fluid bFGF concentrations. Synovial fluid levels of bFGF and VEGF were elevated but could not be used to distinguish rheumatoid arthritis from other forms of inflammatory arthritis.en
dc.language.isoenen
dc.publisherTaylor & Francis Health Sciencesen
dc.relation.urlhttp://dx.doi.org/10.1080/00365510410003732en
dc.subject.meshAdulten
dc.subject.meshAngiogenic Proteinsen
dc.subject.meshAntirheumatic Agentsen
dc.subject.meshArthritisen
dc.subject.meshArthritis, Rheumatoiden
dc.subject.meshBiological Markersen
dc.subject.meshC-Reactive Proteinen
dc.subject.meshDiagnosis, Differentialen
dc.subject.meshFemaleen
dc.subject.meshFibroblast Growth Factor 2en
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshSteroidsen
dc.subject.meshSynovial Fluiden
dc.subject.meshVascular Endothelial Growth Factor Aen
dc.titleSynovial concentrations of the angiogenic peptides bFGF and VEGF do not discriminate rheumatoid arthritis from other forms of inflammatory arthritisen
dc.typeArticleen
dc.contributor.departmentCentre for Rheumatology Research, University Hospital, Reykjavik, Iceland.en
dc.identifier.journalScandinavian journal of clinical and laboratory investigationen

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