A population-based study on the familial aggregation of cutaneous malignant melanoma in Iceland

2.50
Hdl Handle:
http://hdl.handle.net/2336/6467
Title:
A population-based study on the familial aggregation of cutaneous malignant melanoma in Iceland
Authors:
Eldon, Bjarki Jonsson; Thorlacius, Steinunn; Jonsson, Thorvaldur; Jonasson, Jon Gunnlaugur; Kjartansson, Jens; Bodvarsson, Sigurdur; Steingrimsson, Eirikur; Rafnar, Thorunn
Citation:
Eur. J. Cancer 2006, 42(7):922-6
Issue Date:
1-May-2006
Abstract:
The aim of this study was to characterize the familial nature of cutaneous malignant melanoma (CMM) in Iceland. Risk ratio was used to estimate the risk among relatives of all CMM index cases diagnosed in Iceland over a 45-year period (1955-1999), using data from the National Cancer Registry and a genealogy database that covers the whole of Iceland's population. First-, second-, and third-degree relatives of CMM patients did not have an increased risk of the disease, and no added risk of other types of cancer among relatives was observed, except for thyroid cancer in first-degree male relatives. Seven individuals were diagnosed with two or more primary CMM in this period; none of these individuals had a first or second-degree relative with CMM. Altogether, 2.4% of cases were familial, as defined by commonly used criteria. In conclusion, high-penetrance susceptibility genes do not contribute much to CMM in the Icelandic population. The great majority of CMM cases in Iceland are most likely caused by the interplay between environmental causes and low-risk genes.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B6T68-4JFHDYS-5/2/582e2b6c2a65fb6a6901006cb3d2536c

Full metadata record

DC FieldValue Language
dc.contributor.authorEldon, Bjarki Jonsson-
dc.contributor.authorThorlacius, Steinunn-
dc.contributor.authorJonsson, Thorvaldur-
dc.contributor.authorJonasson, Jon Gunnlaugur-
dc.contributor.authorKjartansson, Jens-
dc.contributor.authorBodvarsson, Sigurdur-
dc.contributor.authorSteingrimsson, Eirikur-
dc.contributor.authorRafnar, Thorunn-
dc.date.accessioned2006-12-08T11:16:30Z-
dc.date.available2006-12-08T11:16:30Z-
dc.date.issued2006-05-01-
dc.date.submitted2006-12-08-
dc.identifier.citationEur. J. Cancer 2006, 42(7):922-6en
dc.identifier.issn0959-8049-
dc.identifier.pmid16530404-
dc.identifier.doi10.1016/j.ejca.2005.11.029-
dc.identifier.otherDAV12-
dc.identifier.urihttp://hdl.handle.net/2336/6467-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThe aim of this study was to characterize the familial nature of cutaneous malignant melanoma (CMM) in Iceland. Risk ratio was used to estimate the risk among relatives of all CMM index cases diagnosed in Iceland over a 45-year period (1955-1999), using data from the National Cancer Registry and a genealogy database that covers the whole of Iceland's population. First-, second-, and third-degree relatives of CMM patients did not have an increased risk of the disease, and no added risk of other types of cancer among relatives was observed, except for thyroid cancer in first-degree male relatives. Seven individuals were diagnosed with two or more primary CMM in this period; none of these individuals had a first or second-degree relative with CMM. Altogether, 2.4% of cases were familial, as defined by commonly used criteria. In conclusion, high-penetrance susceptibility genes do not contribute much to CMM in the Icelandic population. The great majority of CMM cases in Iceland are most likely caused by the interplay between environmental causes and low-risk genes.en
dc.language.isoenen
dc.publisherElsevier Science Ltd.en
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6T68-4JFHDYS-5/2/582e2b6c2a65fb6a6901006cb3d2536cen
dc.subject.meshAdulten
dc.subject.meshFemaleen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHumansen
dc.subject.meshIceland/epidemiologyen
dc.subject.meshMaleen
dc.subject.meshMelanomaen
dc.subject.meshMiddle Ageden
dc.subject.meshPedigreeen
dc.subject.meshRisk Assessmenten
dc.subject.meshRisk Factorsen
dc.subject.meshSkin Neoplasmsen
dc.titleA population-based study on the familial aggregation of cutaneous malignant melanoma in Icelanden
dc.typeArticleen
dc.identifier.journalEuropean journal of cancer (Oxford, England : 1990)en
dc.format.digYES-

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