2.50
Hdl Handle:
http://hdl.handle.net/2336/64715
Title:
Circulating adhesion molecules in allergic and non-allergic asthma
Authors:
Janson, Christer; Ludviksdottir, Dora; Gunnbjornsdottir, Maria; Bjornsson, Eythor H; Håkansson, Lena; Venge, Per
Citation:
Respir Med. 2005, 99(1):45-51
Issue Date:
1-Jan-2005
Abstract:
Circulating forms of adhesion molecules (intercellular-adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin ) are related to the turnover of these molecules on the cell surface. In contrast to the other molecules, the levels of E-selectin probably exclusively reflect the activity of endothelial cells. The aim of this study was to compare levels of circulating adhesion molecules in patients with allergic (AA) and non-allergic asthma (NA) and to relate the levels of soluble adhesion molecules to methacholine responsiveness and lung function. The study comprised 19 patients with AA, 15 patients with NA and 17 healthy subjects. Soluble adhesion molecules, spirometry, methacholine responsiveness and peak flow variability was measured. The group of patients with AA had higher levels of sE-selectin than the reference group (P=0.046). Serum levels of sE-selectin correlated significantly with bronchial responsiveness (r=0.76) and peak flow variability (r=0.75) (P<0.01) in the NA but not in the AA group. All adhesion molecules in AA (P<0.05-<0.001), but only sE-selectin in NA (P<0.05), were correlated to airway conductance. sVCAM-1 was reduced by inhaled steroids (P<0.01). Our results indicate that endothelial cells are activated in asthma and that this activity has a bearing on airflow variability and bronchial responsiveness in NA.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B6WWS-4CN9NCS-1/2/9dfcfc4c0e001a2ac4b13125f55ec2d5

Full metadata record

DC FieldValue Language
dc.contributor.authorJanson, Christer-
dc.contributor.authorLudviksdottir, Dora-
dc.contributor.authorGunnbjornsdottir, Maria-
dc.contributor.authorBjornsson, Eythor H-
dc.contributor.authorHåkansson, Lena-
dc.contributor.authorVenge, Per-
dc.date.accessioned2009-04-08T14:19:13Z-
dc.date.available2009-04-08T14:19:13Z-
dc.date.issued2005-01-01-
dc.date.submitted2009-04-08-
dc.identifier.citationRespir Med. 2005, 99(1):45-51en
dc.identifier.issn0954-6111-
dc.identifier.pmid15672848-
dc.identifier.doi10.1016/j.rmed.2004.05.007.-
dc.identifier.urihttp://hdl.handle.net/2336/64715-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractCirculating forms of adhesion molecules (intercellular-adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin ) are related to the turnover of these molecules on the cell surface. In contrast to the other molecules, the levels of E-selectin probably exclusively reflect the activity of endothelial cells. The aim of this study was to compare levels of circulating adhesion molecules in patients with allergic (AA) and non-allergic asthma (NA) and to relate the levels of soluble adhesion molecules to methacholine responsiveness and lung function. The study comprised 19 patients with AA, 15 patients with NA and 17 healthy subjects. Soluble adhesion molecules, spirometry, methacholine responsiveness and peak flow variability was measured. The group of patients with AA had higher levels of sE-selectin than the reference group (P=0.046). Serum levels of sE-selectin correlated significantly with bronchial responsiveness (r=0.76) and peak flow variability (r=0.75) (P<0.01) in the NA but not in the AA group. All adhesion molecules in AA (P<0.05-<0.001), but only sE-selectin in NA (P<0.05), were correlated to airway conductance. sVCAM-1 was reduced by inhaled steroids (P<0.01). Our results indicate that endothelial cells are activated in asthma and that this activity has a bearing on airflow variability and bronchial responsiveness in NA.en
dc.language.isoenen
dc.publisherW.B. Saundersen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6WWS-4CN9NCS-1/2/9dfcfc4c0e001a2ac4b13125f55ec2d5en
dc.subject.meshAdulten
dc.subject.meshAsthmaen
dc.subject.meshBronchial Hyperreactivityen
dc.subject.meshBronchial Provocation Testsen
dc.subject.meshBronchoconstrictor Agentsen
dc.subject.meshCell Adhesion Moleculesen
dc.subject.meshE-Selectinen
dc.subject.meshFemaleen
dc.subject.meshForced Expiratory Volumeen
dc.subject.meshHumansen
dc.subject.meshIntercellular Adhesion Molecule-1en
dc.subject.meshMaleen
dc.subject.meshMethacholine Chlorideen
dc.subject.meshMiddle Ageden
dc.subject.meshRespiratory Hypersensitivityen
dc.subject.meshVascular Cell Adhesion Molecule-1en
dc.subject.meshVital Capacityen
dc.titleCirculating adhesion molecules in allergic and non-allergic asthmaen
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Sciences, Respiratory Medicine and Allergology, Akademiska sjukhuset, Uppsala University, Uppsala SE 75185, Sweden. christer.janson@medsci.uu.seen
dc.identifier.journalRespiratory medicineen

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