2.50
Hdl Handle:
http://hdl.handle.net/2336/64733
Title:
Cognitive impairment and white matter damage in hypertension: a pilot study
Authors:
Hannesdottir, K; Nitkunan, A; Charlton, R A; Barrick, T R; MacGregor, G A; Markus, H S
Citation:
Acta Neurol. Scand. 2009, 119(4):261-8
Issue Date:
1-Apr-2009
Abstract:
OBJECTIVES: Hypertension has been associated with impaired cognition. Diffusion tensor imaging (DTI) and magnetic resonance spectroscopy were applied to assess white matter abnormalities in treated vs untreated hypertension and if these correlated with neuropsychological performance. METHODS: Subjects were 40 patients with medically treated hypertension (mean age 69.3 years), 10 patients with untreated hypertension (mean age 57.6 years) and 30 normotensive controls (mean age 68.2 years). Hypertension was defined as a previous diagnosis and taking hypertensive medication, or a resting blood pressure of >140/90 mmHg on the day of assessment. RESULTS: Patients with treated hypertension performed worse on immediate (P = 0.037) as well as delayed memory tasks (P = 0.024) compared with normotensive controls. Cognitive performance was worse in untreated compared with treated hypertension on executive functions (P = 0.041) and psychomotor speed (P = 0.003). There was no significant correlation between cognition and any of the imaging parameters in treated hypertension. However, in untreated hypertension the results revealed a positive correlation between an executive functioning and attention composite score and DTI mean diffusivity values (P = 0.016) and between psychomotor speed and spectroscopy NAA/tCr levels (P = 0.015). CONCLUSIONS: These results suggest there is cognitive impairment in hypertension. Treated hypertension was associated with deficits in memory while untreated hypertension revealed a more 'subcortical' pattern of cognitive impairment.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1111/j.1600-0404.2008.01098.x

Full metadata record

DC FieldValue Language
dc.contributor.authorHannesdottir, K-
dc.contributor.authorNitkunan, A-
dc.contributor.authorCharlton, R A-
dc.contributor.authorBarrick, T R-
dc.contributor.authorMacGregor, G A-
dc.contributor.authorMarkus, H S-
dc.date.accessioned2009-04-08T15:51:49Z-
dc.date.available2009-04-08T15:51:49Z-
dc.date.issued2009-04-01-
dc.date.submitted2009-04-08-
dc.identifier.citationActa Neurol. Scand. 2009, 119(4):261-8en
dc.identifier.issn1600-0404-
dc.identifier.pmid18798828-
dc.identifier.doi10.1111/j.1600-0404.2008.01098.x-
dc.identifier.urihttp://hdl.handle.net/2336/64733-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVES: Hypertension has been associated with impaired cognition. Diffusion tensor imaging (DTI) and magnetic resonance spectroscopy were applied to assess white matter abnormalities in treated vs untreated hypertension and if these correlated with neuropsychological performance. METHODS: Subjects were 40 patients with medically treated hypertension (mean age 69.3 years), 10 patients with untreated hypertension (mean age 57.6 years) and 30 normotensive controls (mean age 68.2 years). Hypertension was defined as a previous diagnosis and taking hypertensive medication, or a resting blood pressure of >140/90 mmHg on the day of assessment. RESULTS: Patients with treated hypertension performed worse on immediate (P = 0.037) as well as delayed memory tasks (P = 0.024) compared with normotensive controls. Cognitive performance was worse in untreated compared with treated hypertension on executive functions (P = 0.041) and psychomotor speed (P = 0.003). There was no significant correlation between cognition and any of the imaging parameters in treated hypertension. However, in untreated hypertension the results revealed a positive correlation between an executive functioning and attention composite score and DTI mean diffusivity values (P = 0.016) and between psychomotor speed and spectroscopy NAA/tCr levels (P = 0.015). CONCLUSIONS: These results suggest there is cognitive impairment in hypertension. Treated hypertension was associated with deficits in memory while untreated hypertension revealed a more 'subcortical' pattern of cognitive impairment.en
dc.language.isoenen
dc.publisherMunksgaarden
dc.relation.urlhttp://dx.doi.org/10.1111/j.1600-0404.2008.01098.xen
dc.subject.meshPubMed - in processen
dc.titleCognitive impairment and white matter damage in hypertension: a pilot studyen
dc.typeArticleen
dc.contributor.departmentCentre for Clinical Neuroscience, St Georges University of London, UK. khannesd@landspitali.isen
dc.identifier.journalActa neurologica Scandinavicaen

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