2.50
Hdl Handle:
http://hdl.handle.net/2336/6508
Title:
Familial aggregation of atrial fibrillation in Iceland
Authors:
Arnar, David O; Thorvaldsson, Sverrir; Manolio, Teri A; Thorgeirsson, Gudmundur; Kristjansson, Kristleifur; Hakonarson, Hakon; Stefansson, Kari
Citation:
Eur. Heart J. 2006, 27(6):708-12
Issue Date:
1-Mar-2006
Abstract:
AIMS: To examine the heritability of atrial fibrillation (AF) in Icelanders, utilizing a nationwide genealogy database and population-based data on AF. AF is a disorder with a high prevalence, which has been known to cluster in families, but the heritability of the common form has not been well defined. METHODS AND RESULTS: The study population included 5269 patients diagnosed since 1987 and age-sex-matched controls randomly selected from the genealogy database. Kinship coefficients (KC), expressed as genealogical index of familiality (GIF = average KC x 100,000), were calculated before and after exclusion of relatives separated by one to five meiotic events. Risk ratios (RR) were calculated for first- to fifth-degree relatives. The average pairwise GIF among patients with AF was 15.9 (mean GIF for controls 13.9, 95%CI = 13.3, 14.4); this declined to 15.4 (mean GIF for controls 13.6, 95%CI = 13.1, 14.2) after exclusion of relatives separated by one meiosis and to 13.7 (mean GIF for controls 12.6, 95%CI = 12.1, 13.2), 12.7 (mean GIF for controls 11.9, 95%CI = 11.4, 12.4), and 11.3 (mean GIF for controls 10.6, 95%CI = 10.1, 11.1) after exclusion of relatives within two, three, and four meioses, respectively (all P<0.00001). RRs among relative pairs also declined incrementally, from 1.77 in first-degree relatives to 1.36, 1.18, 1.10, and 1.05 in second- through fifth-degree relatives (all P<0.001), consistent with the declining proportion of alleles shared identically by descent. When the analysis was limited to subjects diagnosed with AF before the age of 60, first-degree relatives of the AF cases were nearly five times more likely to have AF than the general population. CONCLUSION: AF shows strong evidence of heritability among unselected patients in Iceland, suggesting that there may be undiscovered genetic variants underlying the risk of the common form of AF.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://eurheartj.oxfordjournals.org/cgi/content/full/27/6/708

Full metadata record

DC FieldValue Language
dc.contributor.authorArnar, David O-
dc.contributor.authorThorvaldsson, Sverrir-
dc.contributor.authorManolio, Teri A-
dc.contributor.authorThorgeirsson, Gudmundur-
dc.contributor.authorKristjansson, Kristleifur-
dc.contributor.authorHakonarson, Hakon-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2006-12-12T15:29:32Z-
dc.date.available2006-12-12T15:29:32Z-
dc.date.issued2006-03-01-
dc.identifier.citationEur. Heart J. 2006, 27(6):708-12en
dc.identifier.issn0195-668X-
dc.identifier.pmid16428254-
dc.identifier.doi10.1093/eurheartj/ehi727-
dc.identifier.otherCAR12-
dc.identifier.urihttp://hdl.handle.net/2336/6508-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractAIMS: To examine the heritability of atrial fibrillation (AF) in Icelanders, utilizing a nationwide genealogy database and population-based data on AF. AF is a disorder with a high prevalence, which has been known to cluster in families, but the heritability of the common form has not been well defined. METHODS AND RESULTS: The study population included 5269 patients diagnosed since 1987 and age-sex-matched controls randomly selected from the genealogy database. Kinship coefficients (KC), expressed as genealogical index of familiality (GIF = average KC x 100,000), were calculated before and after exclusion of relatives separated by one to five meiotic events. Risk ratios (RR) were calculated for first- to fifth-degree relatives. The average pairwise GIF among patients with AF was 15.9 (mean GIF for controls 13.9, 95%CI = 13.3, 14.4); this declined to 15.4 (mean GIF for controls 13.6, 95%CI = 13.1, 14.2) after exclusion of relatives separated by one meiosis and to 13.7 (mean GIF for controls 12.6, 95%CI = 12.1, 13.2), 12.7 (mean GIF for controls 11.9, 95%CI = 11.4, 12.4), and 11.3 (mean GIF for controls 10.6, 95%CI = 10.1, 11.1) after exclusion of relatives within two, three, and four meioses, respectively (all P<0.00001). RRs among relative pairs also declined incrementally, from 1.77 in first-degree relatives to 1.36, 1.18, 1.10, and 1.05 in second- through fifth-degree relatives (all P<0.001), consistent with the declining proportion of alleles shared identically by descent. When the analysis was limited to subjects diagnosed with AF before the age of 60, first-degree relatives of the AF cases were nearly five times more likely to have AF than the general population. CONCLUSION: AF shows strong evidence of heritability among unselected patients in Iceland, suggesting that there may be undiscovered genetic variants underlying the risk of the common form of AF.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urlhttp://eurheartj.oxfordjournals.org/cgi/content/full/27/6/708en
dc.subject.meshAgeden
dc.subject.meshAtrial Fibrillation/epidemiology/*geneticsen
dc.subject.meshCase-Control Studiesen
dc.subject.meshCohort Studiesen
dc.subject.meshFamily Healthen
dc.subject.meshFemaleen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHumansen
dc.subject.meshIceland/epidemiologyen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPedigreeen
dc.subject.meshRisk Factorsen
dc.titleFamilial aggregation of atrial fibrillation in Icelanden
dc.typeArticleen
dc.identifier.journalEuropean heart journalen
dc.format.digYES-

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