Age-related decline in bone mass measured by dual-energy X-ray absorptiometry and quantitative ultrasound in a population-based sample of both sexes: identification of useful ultrasound thresholds for osteoporosis screening

2.50
Hdl Handle:
http://hdl.handle.net/2336/65196
Title:
Age-related decline in bone mass measured by dual-energy X-ray absorptiometry and quantitative ultrasound in a population-based sample of both sexes: identification of useful ultrasound thresholds for osteoporosis screening
Authors:
Gudmundsdottir, Sigridur L; Indridason, Olafur S; Franzson, Leifur; Sigurdsson, Gunnar
Citation:
J Clin Densitom. 2005, 8(1):80-6
Issue Date:
1-Mar-2005
Abstract:
Quantitative ultrasound (QUS) can be used as a screening tool for low bone mineral density (BMD), but clinical guidelines have not been set. The aim of this population-based, cross-sectional study was to compare age-related changes in bone mass measured by QUS (Lunar, Achilles Plus) and dual-energy X-ray absorptiometry (DXA) in a random sample of 1630 individuals (1041 females, 589 males) 30-85 yr of age. Individuals with DXA T-scores < or =-2.5 at the femoral neck or total hip were identified and receiver operating curves (ROCs) were used to calculate cutoff points for QUS. Sensitivity, specificity, and kappa statistics were calculated. Age-related bone loss was significantly larger with QUS than DXA at all sites in women. For men, the curves were similar for QUS and DXA in the hip. Similar correlations were found between QUS and DXA in different age groups of both sexes (0.36-0.60). For women aged 50-65 yr, a QUS T-score >-1.0 was found to be the most applicable for identifying normal BMD. In the 70-85 yr age group, a T-score <-2.5 for women and a T-score <-0.5 for men seemed reasonable cutoffs for identifying normal BMD (sensitivity: 86-93%; specificity: 28-44%; discordance: 33-73%). Calcaneal QUS cannot be used for the diagnosis of osteoporosis according to WHO criteria, but it can be of use to exclude osteoporosis in 30-40% of our cases.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B82YC-4JR407H-F/2/b5806e685f51a7e4a446e512ffe691c8

Full metadata record

DC FieldValue Language
dc.contributor.authorGudmundsdottir, Sigridur L-
dc.contributor.authorIndridason, Olafur S-
dc.contributor.authorFranzson, Leifur-
dc.contributor.authorSigurdsson, Gunnar-
dc.date.accessioned2009-04-16T14:42:30Z-
dc.date.available2009-04-16T14:42:30Z-
dc.date.issued2005-03-01-
dc.date.submitted2009-04-16-
dc.identifier.citationJ Clin Densitom. 2005, 8(1):80-6en
dc.identifier.issn1094-6950-
dc.identifier.pmid15722591-
dc.identifier.doi10.1385/JCD:8:1:080-
dc.identifier.urihttp://hdl.handle.net/2336/65196-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractQuantitative ultrasound (QUS) can be used as a screening tool for low bone mineral density (BMD), but clinical guidelines have not been set. The aim of this population-based, cross-sectional study was to compare age-related changes in bone mass measured by QUS (Lunar, Achilles Plus) and dual-energy X-ray absorptiometry (DXA) in a random sample of 1630 individuals (1041 females, 589 males) 30-85 yr of age. Individuals with DXA T-scores < or =-2.5 at the femoral neck or total hip were identified and receiver operating curves (ROCs) were used to calculate cutoff points for QUS. Sensitivity, specificity, and kappa statistics were calculated. Age-related bone loss was significantly larger with QUS than DXA at all sites in women. For men, the curves were similar for QUS and DXA in the hip. Similar correlations were found between QUS and DXA in different age groups of both sexes (0.36-0.60). For women aged 50-65 yr, a QUS T-score >-1.0 was found to be the most applicable for identifying normal BMD. In the 70-85 yr age group, a T-score <-2.5 for women and a T-score <-0.5 for men seemed reasonable cutoffs for identifying normal BMD (sensitivity: 86-93%; specificity: 28-44%; discordance: 33-73%). Calcaneal QUS cannot be used for the diagnosis of osteoporosis according to WHO criteria, but it can be of use to exclude osteoporosis in 30-40% of our cases.en
dc.language.isoenen
dc.publisherHumana Pressen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B82YC-4JR407H-F/2/b5806e685f51a7e4a446e512ffe691c8en
dc.subject.meshAbsorptiometry, Photonen
dc.subject.meshAge Factorsen
dc.subject.meshAgeden
dc.subject.meshBone Diseases, Metabolicen
dc.subject.meshCalcaneusen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshOsteoporosisen
dc.subject.meshROC Curveen
dc.subject.meshSensitivity and Specificityen
dc.titleAge-related decline in bone mass measured by dual-energy X-ray absorptiometry and quantitative ultrasound in a population-based sample of both sexes: identification of useful ultrasound thresholds for osteoporosis screeningen
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology & Metabolism, Landspitali-University Hospital, Fossvogur, IS-108 Reykjavik, Iceland.en
dc.identifier.journalJournal of clinical densitometry : the official journal of the International Society for Clinical Densitometryen
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