Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response

2.50
Hdl Handle:
http://hdl.handle.net/2336/65222
Title:
Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response
Authors:
Kristjansson, Sigurdur; Bjarnarson, Stefania P; Wennergren, Göran; Palsdottir, Aslaug H; Arnadottir, Thorgerdur; Haraldsson, Asgeir; Jonsdottir, Ingileif
Citation:
J. Allergy Clin. Immunol. 2005, 116(4):805-11
Issue Date:
1-Oct-2005
Abstract:
BACKGROUND: Respiratory syncytial virus (RSV) infections during infancy are considered to be a risk factor for developing asthma and possibly allergic sensitization. OBJECTIVE: The aim of this study was to investigate the cytokines, chemokines, and eosinophil cationic protein in the nasopharyngeal secretions of infants < or = 7 months of age with RSV infections or other respiratory viral infections and healthy infants as controls. Groups were also analyzed according to age, < or = 3 months and >3 months, and the levels were compared within and between groups. RESULTS: Thirty-nine infants with RSV, 9 with influenza or parainfluenza virus infections and 50 controls with no history of infections, were enrolled in the study. The RSV-infected infants had significantly higher levels of IL-4; macrophage inflammatory protein 1beta, a chemoattractant for T cells; and eosinophil cationic protein in nasopharyngeal secretions compared with the control group. The levels of the TH2 cytokine IL-4 were significantly higher in RSV-infected infants < or = months of age compared with RSV-infected infants >3 months of age. In infants < or = 3 months of age, infections with influenza or parainfluenza virus caused TH2-like responses similar to those produced by RSV. CONCLUSION: Infections with RSV as well as with influenza and parainfluenza virus during early infancy preferentially promote a TH2-like response in the nose with local production of IL-4, IL-5, and macrophage inflammatory protein 1beta and infiltration and activation of eosinophils.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B6WH4-4GY86XD-3/2/f563d3dd26777042cc19f90b419f6e49

Full metadata record

DC FieldValue Language
dc.contributor.authorKristjansson, Sigurdur-
dc.contributor.authorBjarnarson, Stefania P-
dc.contributor.authorWennergren, Göran-
dc.contributor.authorPalsdottir, Aslaug H-
dc.contributor.authorArnadottir, Thorgerdur-
dc.contributor.authorHaraldsson, Asgeir-
dc.contributor.authorJonsdottir, Ingileif-
dc.date.accessioned2009-04-17T09:43:47Z-
dc.date.available2009-04-17T09:43:47Z-
dc.date.issued2005-10-01-
dc.date.submitted2009-04-17-
dc.identifier.citationJ. Allergy Clin. Immunol. 2005, 116(4):805-11en
dc.identifier.issn0091-6749-
dc.identifier.pmid16210054-
dc.identifier.doi10.1016/j.jaci.2005.07.012-
dc.identifier.urihttp://hdl.handle.net/2336/65222-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Respiratory syncytial virus (RSV) infections during infancy are considered to be a risk factor for developing asthma and possibly allergic sensitization. OBJECTIVE: The aim of this study was to investigate the cytokines, chemokines, and eosinophil cationic protein in the nasopharyngeal secretions of infants < or = 7 months of age with RSV infections or other respiratory viral infections and healthy infants as controls. Groups were also analyzed according to age, < or = 3 months and >3 months, and the levels were compared within and between groups. RESULTS: Thirty-nine infants with RSV, 9 with influenza or parainfluenza virus infections and 50 controls with no history of infections, were enrolled in the study. The RSV-infected infants had significantly higher levels of IL-4; macrophage inflammatory protein 1beta, a chemoattractant for T cells; and eosinophil cationic protein in nasopharyngeal secretions compared with the control group. The levels of the TH2 cytokine IL-4 were significantly higher in RSV-infected infants < or = months of age compared with RSV-infected infants >3 months of age. In infants < or = 3 months of age, infections with influenza or parainfluenza virus caused TH2-like responses similar to those produced by RSV. CONCLUSION: Infections with RSV as well as with influenza and parainfluenza virus during early infancy preferentially promote a TH2-like response in the nose with local production of IL-4, IL-5, and macrophage inflammatory protein 1beta and infiltration and activation of eosinophils.en
dc.language.isoenen
dc.publisherMosbyen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6WH4-4GY86XD-3/2/f563d3dd26777042cc19f90b419f6e49en
dc.subject.meshAge Factorsen
dc.subject.meshCase-Control Studiesen
dc.subject.meshChemokinesen
dc.subject.meshCytokinesen
dc.subject.meshEosinophil Cationic Proteinen
dc.subject.meshEosinophilsen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshInfant, Newbornen
dc.subject.meshLeukocyte Counten
dc.subject.meshMaleen
dc.subject.meshRespiratory Syncytial Virus Infectionsen
dc.subject.meshRespiratory Syncytial Virus, Humanen
dc.subject.meshRespiratory Tract Infectionsen
dc.subject.meshTh2 Cellsen
dc.titleRespiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like responseen
dc.typeArticleen
dc.contributor.departmentChildren's Hospital Iceland, Reykjavik, Iceland. sig@landspitali.isen
dc.identifier.journalJournal of allergy and clinical immunologyen

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