Respiratory symptoms and nocturnal gastroesophageal reflux: a population-based study of young adults in three European countries

2.50
Hdl Handle:
http://hdl.handle.net/2336/65493
Title:
Respiratory symptoms and nocturnal gastroesophageal reflux: a population-based study of young adults in three European countries
Authors:
Gislason, Thorarinn; Janson, Christer; Vermeire, Paul; Plaschke, Peter; Bjornsson, Eythor; Gislason, David; Boman, Gunnar
Citation:
Chest. 2002, 121(1):158-63
Issue Date:
1-Jan-2002
Abstract:
STUDY OBJECTIVE: To estimate the possible association between reported symptoms of gastroesophageal reflux (GER) after bedtime, sleep-disordered breathing, respiratory symptoms, and asthma. DESIGN: Cross-sectional international population survey. PARTICIPANTS: Participants consisted of 2,661 subjects (age range, 20 to 48 years) from three countries (Iceland, Belgium, and Sweden), of whom 2,202 were randomly selected from the general population and 459 were added because of reported asthma. MEASUREMENTS: The investigation included a structured interview, spirometry, methacholine challenge, peak flow diary, skin-prick tests, and a questionnaire on sleep disturbances. RESULTS: In the random population sample, 101 subjects (4.6%) reported GER, which was defined as the occurrence of heartburn or belching after going to bed at least once per week. Subjects with nocturnal GER more often were overweight and had symptoms of sleep-disordered breathing than participants not reporting GER. Participants with GER were more likely to report wheezing (adjusted odds ratio [OR], 2.5), breathlessness at rest (adjusted OR, 2.8), and nocturnal breathlessness (adjusted OR, 2.9), and they had increased peak flow variability compared to the subjects without GER. Physician-diagnosed current asthma was reported by 9% of subjects with GER compared to 4% of those not reporting GER (p < 0.05). Subjects with the combination of asthma and GER had a higher prevalence of nocturnal cough, morning phlegm, sleep-related symptoms, and higher peak flow variability than subjects with asthma alone. CONCLUSION: The occurrence of GER after bedtime is strongly associated with both asthma and respiratory symptoms, as well as symptoms of obstructive sleep apnea syndrome. The partial narrowing or occlusion of the upper airway during sleep, followed by an increase in intrathoracic pressure, might predispose the patient to nocturnal GER and, consequently, to respiratory symptoms.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1378/chest.121.1.158

Full metadata record

DC FieldValue Language
dc.contributor.authorGislason, Thorarinn-
dc.contributor.authorJanson, Christer-
dc.contributor.authorVermeire, Paul-
dc.contributor.authorPlaschke, Peter-
dc.contributor.authorBjornsson, Eythor-
dc.contributor.authorGislason, David-
dc.contributor.authorBoman, Gunnar-
dc.date.accessioned2009-04-20T12:58:02Z-
dc.date.available2009-04-20T12:58:02Z-
dc.date.issued2002-01-01-
dc.date.submitted2009-04-20-
dc.identifier.citationChest. 2002, 121(1):158-63en
dc.identifier.issn0012-3692-
dc.identifier.pmid11796445-
dc.identifier.doi10.1378/chest.121.1.158-
dc.identifier.urihttp://hdl.handle.net/2336/65493-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractSTUDY OBJECTIVE: To estimate the possible association between reported symptoms of gastroesophageal reflux (GER) after bedtime, sleep-disordered breathing, respiratory symptoms, and asthma. DESIGN: Cross-sectional international population survey. PARTICIPANTS: Participants consisted of 2,661 subjects (age range, 20 to 48 years) from three countries (Iceland, Belgium, and Sweden), of whom 2,202 were randomly selected from the general population and 459 were added because of reported asthma. MEASUREMENTS: The investigation included a structured interview, spirometry, methacholine challenge, peak flow diary, skin-prick tests, and a questionnaire on sleep disturbances. RESULTS: In the random population sample, 101 subjects (4.6%) reported GER, which was defined as the occurrence of heartburn or belching after going to bed at least once per week. Subjects with nocturnal GER more often were overweight and had symptoms of sleep-disordered breathing than participants not reporting GER. Participants with GER were more likely to report wheezing (adjusted odds ratio [OR], 2.5), breathlessness at rest (adjusted OR, 2.8), and nocturnal breathlessness (adjusted OR, 2.9), and they had increased peak flow variability compared to the subjects without GER. Physician-diagnosed current asthma was reported by 9% of subjects with GER compared to 4% of those not reporting GER (p < 0.05). Subjects with the combination of asthma and GER had a higher prevalence of nocturnal cough, morning phlegm, sleep-related symptoms, and higher peak flow variability than subjects with asthma alone. CONCLUSION: The occurrence of GER after bedtime is strongly associated with both asthma and respiratory symptoms, as well as symptoms of obstructive sleep apnea syndrome. The partial narrowing or occlusion of the upper airway during sleep, followed by an increase in intrathoracic pressure, might predispose the patient to nocturnal GER and, consequently, to respiratory symptoms.en
dc.language.isoenen
dc.publisherAmerican College of Chest Physiciansen
dc.relation.urlhttp://dx.doi.org/10.1378/chest.121.1.158en
dc.subject.meshAdulten
dc.subject.meshAsthmaen
dc.subject.meshBelgiumen
dc.subject.meshCausalityen
dc.subject.meshComorbidityen
dc.subject.meshCross-Cultural Comparisonen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshFemaleen
dc.subject.meshGastroesophageal Refluxen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshSleep Apnea Syndromesen
dc.subject.meshSwedenen
dc.titleRespiratory symptoms and nocturnal gastroesophageal reflux: a population-based study of young adults in three European countriesen
dc.typeArticleen
dc.contributor.departmentDepartment of Lung Medicine, Vifilsstadir Hospital, Gardabaer, Iceland.en
dc.identifier.journalChesten

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.