Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey

2.50
Hdl Handle:
http://hdl.handle.net/2336/6583
Title:
Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey
Authors:
Gómez Real, F; Svanes, C; Bjornsson, E H; Franklin, K A; Franklin, K; Gislason, D; Gislason, T; Gulsvik, A; Janson, C; Jögi, R; Kiserud, T; Norbäck, D; Nyström, L; Torén, K; Wentzel-Larsen, T; Omenaas, E
Citation:
Thorax 2006, 61(1):34-40
Issue Date:
1-Jan-2006
Abstract:
BACKGROUND: Hormone replacement therapy (HRT) and obesity both appear to increase the risk of asthma. A study was undertaken to investigate the association of HRT with asthma and hay fever in a population of perimenopausal women, focusing on a possible interaction with body mass index (BMI). METHODS: A postal questionnaire was sent to population based samples in Denmark, Estonia, Iceland, Norway, and Sweden in 1999-2001, and 8588 women aged 25-54 years responded (77%). Pregnant women, women using oral contraceptives, and women <46 years were excluded. Analyses included 2206 women aged 46-54 years of which 884 were menopausal and 540 used HRT. Stratified analyses by BMI in tertiles were performed. RESULTS: HRT was associated with an increased risk for asthma (OR 1.57 (95% CI 1.07 to 2.30)), wheeze (OR 1.60 (95% CI 1.22 to 2.10)), and hay fever (OR 1.48 (95% CI 1.15 to 1.90)). The associations with asthma and wheeze were significantly stronger among women with BMI in the lower tertile (asthma OR 2.41 (95% CI 1.21 to 4.77); wheeze OR 2.04 (95% CI 1.23 to 3.36)) than in heavier women (asthma: p(interaction) = 0.030; wheeze: p(interaction) = 0.042). Increasing BMI was associated with more asthma (OR 1.08 (95% CI 1.05 to 1.12) per kg/m2). This effect was only found in women not taking HRT (OR 1.10 (95% CI 1.05 to 1.14) per kg/m2); no such association was detected in HRT users (OR 1.00 (95% CI 0.92 to 1.08) per kg/m2) (p(interaction) = 0.046). Menopause was not significantly associated with asthma, wheeze, or hay fever. CONCLUSIONS: In perimenopausal women there is an interaction between HRT and BMI in the effects on asthma. Lean women who were HRT users had as high a risk for asthma as overweight women not taking HRT. It is suggested that HRT and overweight increase the risk of asthma through partly common pathways.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://thorax.bmj.com/cgi/content/full/61/1/34

Full metadata record

DC FieldValue Language
dc.contributor.authorGómez Real, F-
dc.contributor.authorSvanes, C-
dc.contributor.authorBjornsson, E H-
dc.contributor.authorFranklin, K A-
dc.contributor.authorFranklin, K-
dc.contributor.authorGislason, D-
dc.contributor.authorGislason, T-
dc.contributor.authorGulsvik, A-
dc.contributor.authorJanson, C-
dc.contributor.authorJögi, R-
dc.contributor.authorKiserud, T-
dc.contributor.authorNorbäck, D-
dc.contributor.authorNyström, L-
dc.contributor.authorTorén, K-
dc.contributor.authorWentzel-Larsen, T-
dc.contributor.authorOmenaas, E-
dc.date.accessioned2006-12-15T14:43:21Z-
dc.date.available2006-12-15T14:43:21Z-
dc.date.issued2006-01-01-
dc.date.submitted2006-12-15-
dc.identifier.citationThorax 2006, 61(1):34-40en
dc.identifier.issn0040-6376-
dc.identifier.pmid16244093-
dc.identifier.doi10.1136/thx.2005.040881-
dc.identifier.otherPAD12-
dc.identifier.urihttp://hdl.handle.net/2336/6583-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Hormone replacement therapy (HRT) and obesity both appear to increase the risk of asthma. A study was undertaken to investigate the association of HRT with asthma and hay fever in a population of perimenopausal women, focusing on a possible interaction with body mass index (BMI). METHODS: A postal questionnaire was sent to population based samples in Denmark, Estonia, Iceland, Norway, and Sweden in 1999-2001, and 8588 women aged 25-54 years responded (77%). Pregnant women, women using oral contraceptives, and women <46 years were excluded. Analyses included 2206 women aged 46-54 years of which 884 were menopausal and 540 used HRT. Stratified analyses by BMI in tertiles were performed. RESULTS: HRT was associated with an increased risk for asthma (OR 1.57 (95% CI 1.07 to 2.30)), wheeze (OR 1.60 (95% CI 1.22 to 2.10)), and hay fever (OR 1.48 (95% CI 1.15 to 1.90)). The associations with asthma and wheeze were significantly stronger among women with BMI in the lower tertile (asthma OR 2.41 (95% CI 1.21 to 4.77); wheeze OR 2.04 (95% CI 1.23 to 3.36)) than in heavier women (asthma: p(interaction) = 0.030; wheeze: p(interaction) = 0.042). Increasing BMI was associated with more asthma (OR 1.08 (95% CI 1.05 to 1.12) per kg/m2). This effect was only found in women not taking HRT (OR 1.10 (95% CI 1.05 to 1.14) per kg/m2); no such association was detected in HRT users (OR 1.00 (95% CI 0.92 to 1.08) per kg/m2) (p(interaction) = 0.046). Menopause was not significantly associated with asthma, wheeze, or hay fever. CONCLUSIONS: In perimenopausal women there is an interaction between HRT and BMI in the effects on asthma. Lean women who were HRT users had as high a risk for asthma as overweight women not taking HRT. It is suggested that HRT and overweight increase the risk of asthma through partly common pathways.en
dc.language.isoenen
dc.publisherBritish Medical Assnen
dc.relation.urlhttp://thorax.bmj.com/cgi/content/full/61/1/34en
dc.subject.meshAdulten
dc.subject.meshAsthmaen
dc.subject.meshBody Mass Indexen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshFemaleen
dc.subject.meshHormone Replacement Therapyen
dc.subject.meshMiddle Ageden
dc.subject.meshPerimenopauseen
dc.subject.meshQuestionnairesen
dc.subject.meshRhinitis, Allergic, Seasonalen
dc.subject.meshSmokingen
dc.titleHormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional surveyen
dc.typeArticleen
dc.identifier.journalThoraxen
dc.format.digYES-

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