2.50
Hdl Handle:
http://hdl.handle.net/2336/66697
Title:
Dorzolamide increases retinal oxygen tension after branch retinal vein occlusion
Authors:
Noergaard, Michael Hove; Bach-Holm, Daniella; Scherfig, Erik; Bang, Kurt; Jensen, Peter Koch; Kiilgaard, Jens Folke; Stefansson, Einar; la Cour, Morten
Citation:
Invest. Ophthalmol. Vis. Sci. 2008, 49(3):1136-41
Issue Date:
1-Mar-2008
Abstract:
PURPOSE: To study the effect of dorzolamide on the preretinal oxygen tension (RPO(2)) in retinal areas affected by experimental branch retinal vein occlusion (BRVO) in pigs. METHODS: Experimental BRVO was induced by diathermy close to the optic disc. RPO(2) was measured with an oxygen-sensitive electrode 0.5 mm above the BRVO-affected area, which was compared to the retinal areas not affected by BRVO. In one group of five pigs, RPO(2) was measured at baseline, 1 and 3 hours after BRVO, and after intravenous injection of 500 mg dorzolamide. In a second group of five pigs, RPO(2) was measured 1 week after the BRVO, both before and after intravenous injection of 500 mg dorzolamide. RESULTS: The average baseline RPO(2) was 2.64 +/- 0.09 kPa (mean +/- SD). In the BRVO-affected areas, RPO(2) decreased significantly (by 0.67 +/- 0.29 and 0.94 +/- 0.13 kPa) at 1 hour and 3 hours after BRVO induction. In the non-BRVO areas RPO(2) increased significantly (by 0.51 +/- 0.14 kPa) 1 hour after BRVO induction, but subsequently decreased and reached baseline 3 hours after BRVO induction. One week after BRVO induction, RPO(2) was 0.67 +/- 0.29 kPa lower in affected areas when compared with the non-BRVO areas. In the BRVO-affected areas, dorzolamide increased RPO(2) significantly (by 0.36 +/- 0.21 kPa at 3 to 4 hours and by 0.67 +/- 0.40 kPa) 1 week after BRVO induction. CONCLUSIONS: Retinal hypoxia induced by experimental BRVO remained significant 1 week after BRVO. Dorzolamide increased retinal oxygen tension in the BRVO-affected areas both at 4 hours and 1 week after experimental BRVO in pigs.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.iovs.org/cgi/content/abstract/49/3/1136

Full metadata record

DC FieldValue Language
dc.contributor.authorNoergaard, Michael Hove-
dc.contributor.authorBach-Holm, Daniella-
dc.contributor.authorScherfig, Erik-
dc.contributor.authorBang, Kurt-
dc.contributor.authorJensen, Peter Koch-
dc.contributor.authorKiilgaard, Jens Folke-
dc.contributor.authorStefansson, Einar-
dc.contributor.authorla Cour, Morten-
dc.date.accessioned2009-04-30T09:43:16Z-
dc.date.available2009-04-30T09:43:16Z-
dc.date.issued2008-03-01-
dc.date.submitted2009-04-30-
dc.identifier.citationInvest. Ophthalmol. Vis. Sci. 2008, 49(3):1136-41en
dc.identifier.issn0146-0404-
dc.identifier.pmid18326741-
dc.identifier.doi10.1167/iovs.07-0508-
dc.identifier.urihttp://hdl.handle.net/2336/66697-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPURPOSE: To study the effect of dorzolamide on the preretinal oxygen tension (RPO(2)) in retinal areas affected by experimental branch retinal vein occlusion (BRVO) in pigs. METHODS: Experimental BRVO was induced by diathermy close to the optic disc. RPO(2) was measured with an oxygen-sensitive electrode 0.5 mm above the BRVO-affected area, which was compared to the retinal areas not affected by BRVO. In one group of five pigs, RPO(2) was measured at baseline, 1 and 3 hours after BRVO, and after intravenous injection of 500 mg dorzolamide. In a second group of five pigs, RPO(2) was measured 1 week after the BRVO, both before and after intravenous injection of 500 mg dorzolamide. RESULTS: The average baseline RPO(2) was 2.64 +/- 0.09 kPa (mean +/- SD). In the BRVO-affected areas, RPO(2) decreased significantly (by 0.67 +/- 0.29 and 0.94 +/- 0.13 kPa) at 1 hour and 3 hours after BRVO induction. In the non-BRVO areas RPO(2) increased significantly (by 0.51 +/- 0.14 kPa) 1 hour after BRVO induction, but subsequently decreased and reached baseline 3 hours after BRVO induction. One week after BRVO induction, RPO(2) was 0.67 +/- 0.29 kPa lower in affected areas when compared with the non-BRVO areas. In the BRVO-affected areas, dorzolamide increased RPO(2) significantly (by 0.36 +/- 0.21 kPa at 3 to 4 hours and by 0.67 +/- 0.40 kPa) 1 week after BRVO induction. CONCLUSIONS: Retinal hypoxia induced by experimental BRVO remained significant 1 week after BRVO. Dorzolamide increased retinal oxygen tension in the BRVO-affected areas both at 4 hours and 1 week after experimental BRVO in pigs.en
dc.language.isoenen
dc.publisherAssociation For Research In Vision And Ophthalmology (Arvo)en
dc.relation.urlhttp://www.iovs.org/cgi/content/abstract/49/3/1136en
dc.subject.meshAnimalsen
dc.titleDorzolamide increases retinal oxygen tension after branch retinal vein occlusionen
dc.typeArticleen
dc.contributor.departmentDepartment of Ophthalmology, Rigshospitalet, Copenhagen, Denmark. hovemichael@yahoo.comen
dc.identifier.journalInvestigative ophthalmology & visual scienceen

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