2.50
Hdl Handle:
http://hdl.handle.net/2336/6673
Title:
Disseminated invasive aspergillosis in a patient with acute leukaemia
Authors:
Gottfredsson, Magnus; Steingrimsdottir, Hlif
Citation:
Acta Biomed 2006, 77 Suppl 2:10-3
Issue Date:
1-Mar-2006
Abstract:
A 46-year-old previously healthy woman was diagnosed with acute lymphoblastic leukaemia. The induction phase was complicated by alpha-haemolytic streptococcal bacteremia which responded to antibacterial therapy. Subsequently, the patient developed pneumonie due to Chlamydiapneumoniae which responded to macrolides. Following this infection the patient developed recurrent fever and new pulmonary infiltrates were noted. Bronchoscopy was performed and treatment was administered with liposomal amphotericin B (L-AmB, AmBisome) for two days, but was complicated by acute renal failure. Aspergillus fumigatus was cultured from bronchoalveolar lavage fluid (three samples). L-AmB was discontinued and voriconazole and caspofungin were administered. Despite aggressive antifungal therapy the patient developed progressive invasive infection, with central nervous system involvement as well as lesions appearing in the kidneys and liver. The patient died one week following the diagnosis of aspergillosis.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.actabiomedica.it/data/2006/supp_2_2006/gottfredsson.pdf

Full metadata record

DC FieldValue Language
dc.contributor.authorGottfredsson, Magnus-
dc.contributor.authorSteingrimsdottir, Hlif-
dc.date.accessioned2006-12-20T09:58:07Z-
dc.date.available2006-12-20T09:58:07Z-
dc.date.issued2006-03-01-
dc.date.submitted2006-12-20-
dc.identifier.citationActa Biomed 2006, 77 Suppl 2:10-3en
dc.identifier.issn0392-4203-
dc.identifier.pmid16918060-
dc.identifier.otherTDM12-
dc.identifier.otherHEM12-
dc.identifier.urihttp://hdl.handle.net/2336/6673-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractA 46-year-old previously healthy woman was diagnosed with acute lymphoblastic leukaemia. The induction phase was complicated by alpha-haemolytic streptococcal bacteremia which responded to antibacterial therapy. Subsequently, the patient developed pneumonie due to Chlamydiapneumoniae which responded to macrolides. Following this infection the patient developed recurrent fever and new pulmonary infiltrates were noted. Bronchoscopy was performed and treatment was administered with liposomal amphotericin B (L-AmB, AmBisome) for two days, but was complicated by acute renal failure. Aspergillus fumigatus was cultured from bronchoalveolar lavage fluid (three samples). L-AmB was discontinued and voriconazole and caspofungin were administered. Despite aggressive antifungal therapy the patient developed progressive invasive infection, with central nervous system involvement as well as lesions appearing in the kidneys and liver. The patient died one week following the diagnosis of aspergillosis.en
dc.language.isoenen
dc.publisherMattioli,en
dc.relation.urlhttp://www.actabiomedica.it/data/2006/supp_2_2006/gottfredsson.pdfen
dc.subject.meshAmphotericin Ben
dc.subject.meshAnti-Bacterial Agentsen
dc.subject.meshAntifungal Agentsen
dc.subject.meshAntineoplastic Combined Chemotherapy Protocolsen
dc.subject.meshAspergillosisen
dc.subject.meshBacteremiaen
dc.subject.meshChlamydophila Infectionsen
dc.subject.meshChlamydophila pneumoniaeen
dc.subject.meshDoxorubicinen
dc.subject.meshDrug Resistance, Multiple, Fungalen
dc.subject.meshDrug Therapy, Combinationen
dc.subject.meshFatal Outcomeen
dc.subject.meshFemaleen
dc.subject.meshImmunocompromised Hosten
dc.subject.meshHumansen
dc.subject.meshKidney Failure, Acuteen
dc.subject.meshLeukemia, Pre-B-Cellen
dc.subject.meshLiposomesen
dc.subject.meshLung Diseases, Fungalen
dc.subject.meshMethotrexateen
dc.subject.meshMedical Futilityen
dc.subject.meshNeuroaspergillosisen
dc.subject.meshPeptides, Cyclicen
dc.subject.meshPneumonia, Bacterialen
dc.subject.meshPyrimidinesen
dc.subject.meshStreptococcal Infectionsen
dc.titleDisseminated invasive aspergillosis in a patient with acute leukaemiaen
dc.typeArticleen
dc.format.digYES-

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