Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort

2.50
Hdl Handle:
http://hdl.handle.net/2336/66953
Title:
Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort
Authors:
Urowitz, M B; Gladman, D; Ibañez, D; Fortin, P; Sanchez-Guerrero, J; Bae, S; Clarke, A; Bernatsky, S; Gordon, C; Hanly, J; Wallace, D; Isenberg, D; Ginzler, E; Merrill, J; Alarcon, G; Steinsson, K; Petri, M; Dooley, M A; Bruce, I; Manzi, S; Khamashta, M; Ramsey-Goldman, R; Zoma, A; Sturfelt, G; Nived, O; Maddison, P; Font, J; van Vollenhoven, R; Aranow, C; Kalunian, K; Stoll, T; Buyon, J
Citation:
Lupus. 2007, 16(9):731-5
Issue Date:
2007
Abstract:
Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and hypercholesterolemia (36%). Only 15% of the patients were postmenopausal, 16% were current smokers and 3.6% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://lup.sagepub.com/cgi/content/abstract/16/9/731

Full metadata record

DC FieldValue Language
dc.contributor.authorUrowitz, M B-
dc.contributor.authorGladman, D-
dc.contributor.authorIbañez, D-
dc.contributor.authorFortin, P-
dc.contributor.authorSanchez-Guerrero, J-
dc.contributor.authorBae, S-
dc.contributor.authorClarke, A-
dc.contributor.authorBernatsky, S-
dc.contributor.authorGordon, C-
dc.contributor.authorHanly, J-
dc.contributor.authorWallace, D-
dc.contributor.authorIsenberg, D-
dc.contributor.authorGinzler, E-
dc.contributor.authorMerrill, J-
dc.contributor.authorAlarcon, G-
dc.contributor.authorSteinsson, K-
dc.contributor.authorPetri, M-
dc.contributor.authorDooley, M A-
dc.contributor.authorBruce, I-
dc.contributor.authorManzi, S-
dc.contributor.authorKhamashta, M-
dc.contributor.authorRamsey-Goldman, R-
dc.contributor.authorZoma, A-
dc.contributor.authorSturfelt, G-
dc.contributor.authorNived, O-
dc.contributor.authorMaddison, P-
dc.contributor.authorFont, J-
dc.contributor.authorvan Vollenhoven, R-
dc.contributor.authorAranow, C-
dc.contributor.authorKalunian, K-
dc.contributor.authorStoll, T-
dc.contributor.authorBuyon, J-
dc.date.accessioned2009-05-04T09:56:37Z-
dc.date.available2009-05-04T09:56:37Z-
dc.date.issued2007-
dc.date.submitted2009-05-04-
dc.identifier.citationLupus. 2007, 16(9):731-5en
dc.identifier.issn0961-2033-
dc.identifier.pmid17728367-
dc.identifier.doi10.1177/0961203307081113-
dc.identifier.urihttp://hdl.handle.net/2336/66953-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractSystemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and hypercholesterolemia (36%). Only 15% of the patients were postmenopausal, 16% were current smokers and 3.6% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE.en
dc.language.isoenen
dc.publisherSAGE Publicationsen
dc.relation.urlhttp://lup.sagepub.com/cgi/content/abstract/16/9/731en
dc.subject.meshCohort Studiesen
dc.titleClinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohorten
dc.typeArticleen
dc.contributor.departmentSLICC Registry for Atherosclerosis Coordinating Centre, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada.en
dc.identifier.journalLupusen

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