2.50
Hdl Handle:
http://hdl.handle.net/2336/67874
Title:
No evidence for linkage of schizophrenia to DXS7 at chromosome Xp11
Authors:
Kalsi, G; Gamble, D; Curtis, D; Brynjolfsson, J; Sigmundsson, T; Butler, R; Read, T; Murphy, P; Petursson, H; Gurling, H M
Citation:
Psychiatr. Genet. 1999, 9(4):197-9
Issue Date:
1-Dec-1999
Abstract:
There have been claims that a gene on the X chromosome may contribute to susceptibility to schizophrenia. Crow (1988) initially proposed that such a gene might lie in the pseudoautosomal region, but when evidence that weakened this hypothesis accumulated, he proposed that a susceptibility locus might be present elsewhere on the sex chromosomes instead. DeLisi et al. (1994) found a small nonsignificant positive lod score between the marker DXS7 and schizophrenia, but other failed to replicate this finding. Another study reported by Crow and DeLisi's group was also weakly positive for this marker (Dann et al., 1997). This locus was then investigated in a collaborative study by Laval et al. (1997), which produced a nonparametric lod score of 2.44. Using a sample of 17 pedigrees from Britain and Iceland, we have also tested the hypothesis of linkage between DXS7 and schizophrenia. The 17 families were selected from a larger sample on the basis of an absence of male-to-male transmission for schizophrenia. These families were originally selected for having multiple cases of schizophrenia within them and for having no cases of bipolar affective disorder. We genotyped subjects for a marker at DXS7 and performed classical lod score and model-free linkage analysis using broad and narrow definitions of affection with schizophrenia. We found strongly negative lod scores and no evidence for linkage using model-free analysis. Therefore, this study does not support the hypothesis of linkage of schizophrenia to DXS7, and the evidence for a susceptibility locus on this part of the X chromosome is weakened.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=fulltext&AN=00041444-199912000-00006&D=ovftd

Full metadata record

DC FieldValue Language
dc.contributor.authorKalsi, G-
dc.contributor.authorGamble, D-
dc.contributor.authorCurtis, D-
dc.contributor.authorBrynjolfsson, J-
dc.contributor.authorSigmundsson, T-
dc.contributor.authorButler, R-
dc.contributor.authorRead, T-
dc.contributor.authorMurphy, P-
dc.contributor.authorPetursson, H-
dc.contributor.authorGurling, H M-
dc.date.accessioned2009-05-12T11:24:43Z-
dc.date.available2009-05-12T11:24:43Z-
dc.date.issued1999-12-01-
dc.date.submitted2009-05-12-
dc.identifier.citationPsychiatr. Genet. 1999, 9(4):197-9en
dc.identifier.issn0955-8829-
dc.identifier.pmid10697827-
dc.identifier.urihttp://hdl.handle.net/2336/67874-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThere have been claims that a gene on the X chromosome may contribute to susceptibility to schizophrenia. Crow (1988) initially proposed that such a gene might lie in the pseudoautosomal region, but when evidence that weakened this hypothesis accumulated, he proposed that a susceptibility locus might be present elsewhere on the sex chromosomes instead. DeLisi et al. (1994) found a small nonsignificant positive lod score between the marker DXS7 and schizophrenia, but other failed to replicate this finding. Another study reported by Crow and DeLisi's group was also weakly positive for this marker (Dann et al., 1997). This locus was then investigated in a collaborative study by Laval et al. (1997), which produced a nonparametric lod score of 2.44. Using a sample of 17 pedigrees from Britain and Iceland, we have also tested the hypothesis of linkage between DXS7 and schizophrenia. The 17 families were selected from a larger sample on the basis of an absence of male-to-male transmission for schizophrenia. These families were originally selected for having multiple cases of schizophrenia within them and for having no cases of bipolar affective disorder. We genotyped subjects for a marker at DXS7 and performed classical lod score and model-free linkage analysis using broad and narrow definitions of affection with schizophrenia. We found strongly negative lod scores and no evidence for linkage using model-free analysis. Therefore, this study does not support the hypothesis of linkage of schizophrenia to DXS7, and the evidence for a susceptibility locus on this part of the X chromosome is weakened.en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=fulltext&AN=00041444-199912000-00006&D=ovftden
dc.subject.meshChromosome Mappingen
dc.subject.meshChromosomes, Human, Pair 11en
dc.subject.meshFemaleen
dc.subject.meshGenetic Markersen
dc.subject.meshGreat Britainen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshLinkage (Genetics)en
dc.subject.meshLod Scoreen
dc.subject.meshMaleen
dc.subject.meshPedigreeen
dc.subject.meshSchizophreniaen
dc.subject.meshStatistics, Nonparametricen
dc.titleNo evidence for linkage of schizophrenia to DXS7 at chromosome Xp11en
dc.typeArticleen
dc.contributor.departmentWindeyer Institute of Medical Research, Department of Psychiatry and Behavioural Sciences, UCL Medical School, London, UK.en
dc.identifier.journalPsychiatric geneticsen

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