Cardiovascular death in women who had hypertension in pregnancy: a case-control study

2.50
Hdl Handle:
http://hdl.handle.net/2336/68576
Title:
Cardiovascular death in women who had hypertension in pregnancy: a case-control study
Authors:
Arnadottir, Gerdur A; Geirsson, Reynir T; Arngrimsson, Reynir; Jonsdottir, Lilja S; Olafsson, Orn
Citation:
BJOG. 2005, 112(3):286-92
Issue Date:
1-Mar-2005
Abstract:
OBJECTIVE: To determine whether an association exists between hypertension in pregnancy and later development of cardiovascular disease. DESIGN: Case-control study of women who delivered with and without hypertensive complications during the same period. SETTING: University Hospital in Reykjavik, Iceland. POPULATION: Three hundred and twenty-five women with hypertension in pregnancy (blood pressure > or =140/90 mmHg after 20 weeks of gestation) in the years 1931-1947, graded by severity. For each case, two normotensive control women, delivering before or after the case and matched for parity and age were selected, giving a total of 629 women. METHODS: Causes of death were evaluated for the presence of ischaemic heart disease, cerebrovascular events and cancer, up until the end of 1996. MAIN OUTCOME MEASURES: Survival curves, median survival times, risk of death by age group and severity of disease. RESULTS: Death with evidence of ischaemic heart disease was more common in cases (24.3%) than in control women (14.6%) (RR 1.66; 95% CI 1.27-2.17). Cerebrovascular event deaths occurred in 9.5% of cases and in 6.5% of controls (RR 1.46; 95% CI 0.94-2.28). Cancer death rates were not different (RR 1.22; 95% CI 0.91-1.63). Survival times were shorter on average by three to nine years as a consequence of cardiovascular disease. This varied by age group in the index pregnancy for women with a history of hypertension in pregnancy. The effect was smaller if the case pregnancy occurred at a young age. There was a linear trend with increasing severity of hypertensive disease in pregnancy in death rates from ischaemic heart disease (chi(2) (1)= 5.8, P= 0.02). CONCLUSIONS: Long term follow up suggests an increased risk of death from ischaemic heart disease and cerebrovascular events among women who suffered hypertension in pregnancy.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1111/j.1471-0528.2004.00396.x

Full metadata record

DC FieldValue Language
dc.contributor.authorArnadottir, Gerdur A-
dc.contributor.authorGeirsson, Reynir T-
dc.contributor.authorArngrimsson, Reynir-
dc.contributor.authorJonsdottir, Lilja S-
dc.contributor.authorOlafsson, Orn-
dc.date.accessioned2009-05-19T15:32:27Z-
dc.date.available2009-05-19T15:32:27Z-
dc.date.issued2005-03-01-
dc.date.submitted2009-05-18-
dc.identifier.citationBJOG. 2005, 112(3):286-92en
dc.identifier.issn1470-0328-
dc.identifier.pmid15713141-
dc.identifier.doi10.1111/j.1471-0528.2004.00396.x-
dc.identifier.urihttp://hdl.handle.net/2336/68576-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: To determine whether an association exists between hypertension in pregnancy and later development of cardiovascular disease. DESIGN: Case-control study of women who delivered with and without hypertensive complications during the same period. SETTING: University Hospital in Reykjavik, Iceland. POPULATION: Three hundred and twenty-five women with hypertension in pregnancy (blood pressure > or =140/90 mmHg after 20 weeks of gestation) in the years 1931-1947, graded by severity. For each case, two normotensive control women, delivering before or after the case and matched for parity and age were selected, giving a total of 629 women. METHODS: Causes of death were evaluated for the presence of ischaemic heart disease, cerebrovascular events and cancer, up until the end of 1996. MAIN OUTCOME MEASURES: Survival curves, median survival times, risk of death by age group and severity of disease. RESULTS: Death with evidence of ischaemic heart disease was more common in cases (24.3%) than in control women (14.6%) (RR 1.66; 95% CI 1.27-2.17). Cerebrovascular event deaths occurred in 9.5% of cases and in 6.5% of controls (RR 1.46; 95% CI 0.94-2.28). Cancer death rates were not different (RR 1.22; 95% CI 0.91-1.63). Survival times were shorter on average by three to nine years as a consequence of cardiovascular disease. This varied by age group in the index pregnancy for women with a history of hypertension in pregnancy. The effect was smaller if the case pregnancy occurred at a young age. There was a linear trend with increasing severity of hypertensive disease in pregnancy in death rates from ischaemic heart disease (chi(2) (1)= 5.8, P= 0.02). CONCLUSIONS: Long term follow up suggests an increased risk of death from ischaemic heart disease and cerebrovascular events among women who suffered hypertension in pregnancy.en
dc.language.isoenen
dc.publisherBlackwell Pub.en
dc.relation.urlhttp://dx.doi.org/10.1111/j.1471-0528.2004.00396.xen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAge Distributionen
dc.subject.meshAgeden
dc.subject.meshCerebrovascular Disordersen
dc.subject.meshEpidemiologic Methodsen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshHypertension, Pregnancy-Induceden
dc.subject.meshIcelanden
dc.subject.meshMiddle Ageden
dc.subject.meshMyocardial Ischemiaen
dc.subject.meshPregnancyen
dc.titleCardiovascular death in women who had hypertension in pregnancy: a case-control studyen
dc.typeArticleen
dc.contributor.departmentDepartment of Obstetrics and Gynecology, Landspitali University Hospital, 101 Reykjavik, Iceland.en
dc.identifier.journalBJOG : an international journal of obstetrics and gynaecologyen

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