2.50
Hdl Handle:
http://hdl.handle.net/2336/68894
Title:
Sveifluspennur í sjónhimnu : áhrif GABA-agonista
Other Titles:
Oscillatory potentials in the retina: the effects of GABA agonists
Authors:
Ársæll Arnarsson; Jón M. Einarsson; Þór Eysteinsson
Citation:
Læknablaðið 1995, 81(5):412-6
Issue Date:
1-May-1995
Abstract:
We have recorded the electroretinogram from 19 superfused eyecups of the Xeiiopus retina in order to assess the effects of agonists of the inhibitory neurotransmitter gamma-aminobutyric acid (GA¬BA), on both oscillatory potentials and the b-wave. We found that in seven eyecups the GABA uptake blocker nipecotic acid (0.1-5 mM) reduced the amplitudes of the oscillatory potentials, without having an effect on the b-wave unless it was applied in larger doses. The GABAB agonist baclofen (0.05-3 mM) reduced the amplitude of the ERG b-wave selectively in seven eyecups tested, without any effect on the amplitude of the oscillatory potentials. The GABAA agonist aminovaleric acid (0.05-3 mM) on the other hand, selectively reduced the oscillatory potentials in five, but had no reliable effects on the Xenopus b-wave. These results suggest that GABAergic mechanisms related to both A and B receptor types induce different influence on the amplitude of the oscillatory potentials and the b-wave.; Við höfum skráð sjónhimnurit úr 19 yfirflæddum augnbikurum vatnakörtu (Xenopus laevis) til þess að rannsaka áhrif mismunandi GABA- (gamma-aminobutyric acid) agonista á sveifluspennur og b-bylgju. GABA-upptökuhamlarinn NIP (nipecotic acid) (0,1-5 mM) dregur úr sveifluspennum, en hefur litil áhrif á b-bylgjuna nema í stærri skömmtum (N=7). GABAB-agonistinn baclofen (0,05-3 mM) dró sérhæft úr spennu b-bylgjunnar án þess að hafa áhrif á sveifluspennumar (N=7). GABAA-agonistinn AVA (aminovaleric acid) (0,05-3 mM) hafði hinsvegar sérhæfð áhrif til lækkunar sveifluspenna, en engin á b-bylgjuna (N=5). Þessar niðurstöður benda til þess að frumur sem hafa A og B GABA-viðtaka hafi mismunandi áhrif á sveifluspennur og b-bylgju sjónhimnurits.
Description:
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open
Additional Links:
http://www.laeknabladid.is

Full metadata record

DC FieldValue Language
dc.contributor.authorÁrsæll Arnarsson-
dc.contributor.authorJón M. Einarsson-
dc.contributor.authorÞór Eysteinsson-
dc.date.accessioned2009-05-25T10:05:11Z-
dc.date.available2009-05-25T10:05:11Z-
dc.date.issued1995-05-01-
dc.date.submitted2009-05-25-
dc.identifier.citationLæknablaðið 1995, 81(5):412-6en
dc.identifier.issn0023-7213-
dc.identifier.urihttp://hdl.handle.net/2336/68894-
dc.descriptionNeðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Openen
dc.description.abstractWe have recorded the electroretinogram from 19 superfused eyecups of the Xeiiopus retina in order to assess the effects of agonists of the inhibitory neurotransmitter gamma-aminobutyric acid (GA¬BA), on both oscillatory potentials and the b-wave. We found that in seven eyecups the GABA uptake blocker nipecotic acid (0.1-5 mM) reduced the amplitudes of the oscillatory potentials, without having an effect on the b-wave unless it was applied in larger doses. The GABAB agonist baclofen (0.05-3 mM) reduced the amplitude of the ERG b-wave selectively in seven eyecups tested, without any effect on the amplitude of the oscillatory potentials. The GABAA agonist aminovaleric acid (0.05-3 mM) on the other hand, selectively reduced the oscillatory potentials in five, but had no reliable effects on the Xenopus b-wave. These results suggest that GABAergic mechanisms related to both A and B receptor types induce different influence on the amplitude of the oscillatory potentials and the b-wave.en
dc.description.abstractVið höfum skráð sjónhimnurit úr 19 yfirflæddum augnbikurum vatnakörtu (Xenopus laevis) til þess að rannsaka áhrif mismunandi GABA- (gamma-aminobutyric acid) agonista á sveifluspennur og b-bylgju. GABA-upptökuhamlarinn NIP (nipecotic acid) (0,1-5 mM) dregur úr sveifluspennum, en hefur litil áhrif á b-bylgjuna nema í stærri skömmtum (N=7). GABAB-agonistinn baclofen (0,05-3 mM) dró sérhæft úr spennu b-bylgjunnar án þess að hafa áhrif á sveifluspennumar (N=7). GABAA-agonistinn AVA (aminovaleric acid) (0,05-3 mM) hafði hinsvegar sérhæfð áhrif til lækkunar sveifluspenna, en engin á b-bylgjuna (N=5). Þessar niðurstöður benda til þess að frumur sem hafa A og B GABA-viðtaka hafi mismunandi áhrif á sveifluspennur og b-bylgju sjónhimnurits.en
dc.language.isoisen
dc.publisherLæknafélag Íslands, Læknafélag Reykjavíkuren
dc.relation.urlhttp://www.laeknabladid.isen
dc.subjectSjónhimnuren
dc.subjectAuguen
dc.subject.meshGABA Antagonistsen
dc.subject.meshGABA Agonistsen
dc.subject.meshRetinaen
dc.subject.meshElectroretinographyen
dc.titleSveifluspennur í sjónhimnu : áhrif GABA-agonistais
dc.title.alternativeOscillatory potentials in the retina: the effects of GABA agonistsen
dc.typeArticleen
dc.identifier.journalLæknablaðiðis
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