Microvascular lesions in the brain and retina: The age, gene/environment susceptibility-Reykjavik study

2.50
Hdl Handle:
http://hdl.handle.net/2336/73933
Title:
Microvascular lesions in the brain and retina: The age, gene/environment susceptibility-Reykjavik study
Authors:
Qiu, Chengxuan; Cotch, Mary Frances; Sigurdsson, Sigurdur; Klein, Ronald; Jonasson, Fridbert; Klein, Barbara E K; Garcia, Melissa; Jonsson, Palmi V; Harris, Tamara B; Eiriksdottir, Gudny; Kjartansson, Olafur; van Buchem, Mark A; Gudnason, Vilmundur; Launer, Lenore J
Citation:
Ann. Neurol. 2009, 65(5):569-76
Issue Date:
1-May-2009
Abstract:
OBJECTIVE: To investigate whether the severity and location of cerebral white matter hyperintensities (WMHs) and brain infarcts are correlated with the signs of retinal microvascular abnormalities in the elderly. METHODS: The study included 4,176 men and women (mean age, 76 years) who participated in the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study. Digital retinal images of both dilated eyes were taken and evaluated for the presence of retinal focal arteriolar signs (focal arteriolar narrowing and arteriovenous nicking) and retinopathy lesions (retinal blot hemorrhages and microaneurysms). Brain magnetic resonance imaging scans were acquired and evaluated for the presence and distribution of cerebral infarcts and WMHs. Logistic and multinomial logistic models were constructed to estimate the association of retinal microvascular signs to brain lesions. RESULTS: Controlling for demographic and major cardiovascular risk factors, we found that retinal focal arteriolar signs, but not retinopathy lesions, were significantly associated with an increasing load of subcortical and periventricular WMHs. The strongest association was found between retinal arteriolar signs and a heavier WMH load, specifically in the subcortical frontal lobe, and periventricular frontal and parietal caps. There was a tendency toward bilateral retinal focal arteriolar narrowing being more strongly associated with the heavier load of subcortical WMHs. Arteriovenous nicking was significantly associated with subcortical infarcts. INTERPRETATION: In older adults, retinal focal arteriolar signs, but not retinopathy lesions, are correlated with the load of diffuse WMHs, particularly those located in the subcortical frontal lobe, and the periventricular frontal and parietal caps of the brain.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1002/ana.21614

Full metadata record

DC FieldValue Language
dc.contributor.authorQiu, Chengxuan-
dc.contributor.authorCotch, Mary Frances-
dc.contributor.authorSigurdsson, Sigurdur-
dc.contributor.authorKlein, Ronald-
dc.contributor.authorJonasson, Fridbert-
dc.contributor.authorKlein, Barbara E K-
dc.contributor.authorGarcia, Melissa-
dc.contributor.authorJonsson, Palmi V-
dc.contributor.authorHarris, Tamara B-
dc.contributor.authorEiriksdottir, Gudny-
dc.contributor.authorKjartansson, Olafur-
dc.contributor.authorvan Buchem, Mark A-
dc.contributor.authorGudnason, Vilmundur-
dc.contributor.authorLauner, Lenore J-
dc.date.accessioned2009-07-15T14:49:15Z-
dc.date.available2009-07-15T14:49:15Z-
dc.date.issued2009-05-01-
dc.date.submitted2009-07-15-
dc.identifier.citationAnn. Neurol. 2009, 65(5):569-76en
dc.identifier.issn1531-8249-
dc.identifier.pmid19475677-
dc.identifier.doi10.1002/ana.21614-
dc.identifier.urihttp://hdl.handle.net/2336/73933-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: To investigate whether the severity and location of cerebral white matter hyperintensities (WMHs) and brain infarcts are correlated with the signs of retinal microvascular abnormalities in the elderly. METHODS: The study included 4,176 men and women (mean age, 76 years) who participated in the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study. Digital retinal images of both dilated eyes were taken and evaluated for the presence of retinal focal arteriolar signs (focal arteriolar narrowing and arteriovenous nicking) and retinopathy lesions (retinal blot hemorrhages and microaneurysms). Brain magnetic resonance imaging scans were acquired and evaluated for the presence and distribution of cerebral infarcts and WMHs. Logistic and multinomial logistic models were constructed to estimate the association of retinal microvascular signs to brain lesions. RESULTS: Controlling for demographic and major cardiovascular risk factors, we found that retinal focal arteriolar signs, but not retinopathy lesions, were significantly associated with an increasing load of subcortical and periventricular WMHs. The strongest association was found between retinal arteriolar signs and a heavier WMH load, specifically in the subcortical frontal lobe, and periventricular frontal and parietal caps. There was a tendency toward bilateral retinal focal arteriolar narrowing being more strongly associated with the heavier load of subcortical WMHs. Arteriovenous nicking was significantly associated with subcortical infarcts. INTERPRETATION: In older adults, retinal focal arteriolar signs, but not retinopathy lesions, are correlated with the load of diffuse WMHs, particularly those located in the subcortical frontal lobe, and the periventricular frontal and parietal caps of the brain.en
dc.language.isoenen
dc.publisherWiley-Lissen
dc.relation.urlhttp://dx.doi.org/10.1002/ana.21614en
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAgingen
dc.subject.meshBrain Diseasesen
dc.subject.meshChi-Square Distributionen
dc.subject.meshDisease Susceptibilityen
dc.subject.meshEnvironmenten
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshImage Processing, Computer-Assisteden
dc.subject.meshLogistic Modelsen
dc.subject.meshMagnetic Resonance Imagingen
dc.subject.meshMaleen
dc.subject.meshMicrovesselsen
dc.subject.meshRetinal Diseasesen
dc.subject.meshRetrospective Studiesen
dc.subject.meshRisk Factorsen
dc.titleMicrovascular lesions in the brain and retina: The age, gene/environment susceptibility-Reykjavik studyen
dc.typeArticleen
dc.contributor.departmentLaboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA.en
dc.identifier.journalAnnals of neurologyen

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