2.50
Hdl Handle:
http://hdl.handle.net/2336/77956
Title:
Gluten sensitivity in patients with IgA nephropathy
Authors:
Smerud, Hilde Kloster; Fellström, Bengt; Hällgren, Roger; Osagie, Sonia; Venge, Per; Kristjansson, Gudjon
Citation:
Nephrol. Dial. Transplant. 2009, 24(8):2476-81
Issue Date:
1-Aug-2009
Abstract:
BACKGROUND: Coeliac disease is more frequent in IgA nephropathy (IgAN) patients compared to the healthy population. Several hypotheses postulate that food antigens like gluten may be involved in the onset of IgAN. METHODS: In this study, we used a recently developed mucosal patch technique to evaluate the rectal mucosal inflammatory reaction to gluten in patients with IgAN (n = 27) compared to healthy subjects (n = 18). The rectal mucosal production of nitric oxide (NO) and release of myeloperoxidase (MPO) and eosinophil cationic protein (ECP) were measured. Serum samples were analysed for IgA and IgG antigliadin antibodies (AGA), IgA antibodies against tissue transglutaminase and IgA endomysium antibodies. RESULTS: Gluten reactivity, defined as increase in MPO and/or NO after gluten exposure, was observed in 8 of 27 IgAN patients. The prevalence of HLA-DQ2 and DQ8 was not increased among gluten-sensitive patients, and the total prevalence among IgAN patients was the same as for the normal population. An elevated serum IgA AGA response was seen in 9 of 27 IgAN patients. The increase in IgA AGA did not correlate with the gluten sensitivity as measured by NO and/or MPO. A specific serum IgG AGA response was seen in one patient only. Antibodies against tissue transglutaminase and endomysium were not observed. CONCLUSION: It is concluded that approximately one-third of our IgAN patients have a rectal mucosal sensitivity to gluten, but without signs of coeliac disease, and we hypothesize that such sub-clinical inflammation to gluten might be involved in the pathogenesis of IgAN in a subgroup of patients.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1093/ndt/gfp133

Full metadata record

DC FieldValue Language
dc.contributor.authorSmerud, Hilde Kloster-
dc.contributor.authorFellström, Bengt-
dc.contributor.authorHällgren, Roger-
dc.contributor.authorOsagie, Sonia-
dc.contributor.authorVenge, Per-
dc.contributor.authorKristjansson, Gudjon-
dc.date.accessioned2009-08-20T09:30:38Z-
dc.date.available2009-08-20T09:30:38Z-
dc.date.issued2009-08-01-
dc.date.submitted2009-08-20-
dc.identifier.citationNephrol. Dial. Transplant. 2009, 24(8):2476-81en
dc.identifier.issn1460-2385-
dc.identifier.pmid19332868-
dc.identifier.doi10.1093/ndt/gfp133-
dc.identifier.urihttp://hdl.handle.net/2336/77956-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Coeliac disease is more frequent in IgA nephropathy (IgAN) patients compared to the healthy population. Several hypotheses postulate that food antigens like gluten may be involved in the onset of IgAN. METHODS: In this study, we used a recently developed mucosal patch technique to evaluate the rectal mucosal inflammatory reaction to gluten in patients with IgAN (n = 27) compared to healthy subjects (n = 18). The rectal mucosal production of nitric oxide (NO) and release of myeloperoxidase (MPO) and eosinophil cationic protein (ECP) were measured. Serum samples were analysed for IgA and IgG antigliadin antibodies (AGA), IgA antibodies against tissue transglutaminase and IgA endomysium antibodies. RESULTS: Gluten reactivity, defined as increase in MPO and/or NO after gluten exposure, was observed in 8 of 27 IgAN patients. The prevalence of HLA-DQ2 and DQ8 was not increased among gluten-sensitive patients, and the total prevalence among IgAN patients was the same as for the normal population. An elevated serum IgA AGA response was seen in 9 of 27 IgAN patients. The increase in IgA AGA did not correlate with the gluten sensitivity as measured by NO and/or MPO. A specific serum IgG AGA response was seen in one patient only. Antibodies against tissue transglutaminase and endomysium were not observed. CONCLUSION: It is concluded that approximately one-third of our IgAN patients have a rectal mucosal sensitivity to gluten, but without signs of coeliac disease, and we hypothesize that such sub-clinical inflammation to gluten might be involved in the pathogenesis of IgAN in a subgroup of patients.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urlhttp://dx.doi.org/10.1093/ndt/gfp133en
dc.subject.meshPubMed in processen
dc.titleGluten sensitivity in patients with IgA nephropathyen
dc.typeArticleen
dc.contributor.departmentSection of Nephrology, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden. hilde.kloster.smerud@smerud.comen
dc.identifier.journalNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Associationen

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