Bandvefsmyndandi berkjungateppa með lungnabólgu : klínísk sérkenni 19 sjúklinga á Íslandi

2.50
Hdl Handle:
http://hdl.handle.net/2336/78457
Title:
Bandvefsmyndandi berkjungateppa með lungnabólgu : klínísk sérkenni 19 sjúklinga á Íslandi
Other Titles:
Bronchiolitis obliterans organizing pneumonia (BOOP). A clinico-pathologic study
Authors:
Ófeigur Tryggvi Þorgeirsson; Steinn Jónsson; Bjarni Agnar Agnarsson; Tryggvi Ásmundsson
Citation:
Læknablaðið 1993, 79(9):349-58
Issue Date:
1-Nov-1993
Abstract:
The diagnosis of BOOP is based on characteristic changes on lung biopsy in patients with a variety of symptoms and radiographic changes. We studied nineteen patients, ten males and nine females, with biopsy proven BOOP. The most common clinical findings were fever, shortness of breath and non-productive cough for less than eight weeks and inspiratory crackles on auscultation. Laboratory tests often revealed increased erythrocyte sedimentation rate, low grade anemia, moderate increase in white blood cell count and arterial hypoxemia. Irregular alveolar infiltrates were the most common radiographic abnormalities. Open lung biopsy was required in three. Seven patients in our study were considered to have idiopathic or primary BOOP with no identifiable cause. Twelve patients had either an underlying bacterial lung infection, rheumatologic disease or cancer. Thirteen patients received corticosteroid treatment, usually oral prednisolone at an initial dose of 30-60 mg/day, for a variable length of time. Predisolone treatment resulted in recovery with clearing of lung infiltrates in all patients but one, who died of myocardial infarction five days after treatment was begun. However relapses occurred in more than half (57%) of those receiving prednisolone. Relapses usually occurred when the prednisolone doses had been reduced below 15 mg/day, and in patients who had been treated for up to 10 months. Recovery ensued when perdnisolone doses were increased. Four patients recovered after treatment with antibiotics alone. BOOP probably represents a non-specific inflammatory response of the lung to a number of insults. The high proportion of cases with an established underlying disease in our study is unique. Our data also suggest that infection may be the most frequent underlying condition in BOOP. Corticosteroids were effective treatment but relapses were common. A thorough search for an underlying disease is warranted, and if recognized, should be treated accordingly.; Bandvefsmyndandi berkjungateppa með lungnabólgu (Bronchiolitis Obliterans Organizing Pneumonia - BOOP) er sjúkdómsgreining byggð á sérkennandi vefjabreytingum í lungum, sem fyrst var lýst af Lange árið 1901 (1). Á undanförnum áratug hefur orðið ljóst að þessum breytingum fylgja oft sérkennandi sjúkdómseinkenni og breytingar á röntgenmynd (2,3)- BOOP hefur því í vaxandi mæli verið skilgreind sem sérstakt sjúkdómsástand. Þessi áhersla á BOOP sem sjálfstæðan sjúkdóm hefur hagnýta þýðingu, því að BOOP hefur svarað barksterameðferð mun betur en aðrir bandvefsmyndandi bólgusjúkdómar í lungum. Í fyrri rannsóknum hefur í fæstum tilfellum fundist orsök fyrir BOOP-breytingum og sjúkdómurinn því talinn vera af óþekktum orsökum (2-7). Það er þó vel þekkt að BOOP-breytingar greinast í tengslum við aðra sjúkdóma, svo sem sýkingar, liðagigt, krabbamein, geislun og fleira (8-10).
Description:
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open
Additional Links:
http://www.laeknabladid.is

Full metadata record

DC FieldValue Language
dc.contributor.authorÓfeigur Tryggvi Þorgeirsson-
dc.contributor.authorSteinn Jónsson-
dc.contributor.authorBjarni Agnar Agnarsson-
dc.contributor.authorTryggvi Ásmundsson-
dc.date.accessioned2009-08-25T13:43:01Z-
dc.date.available2009-08-25T13:43:01Z-
dc.date.issued1993-11-01-
dc.date.submitted2009-08-25-
dc.identifier.citationLæknablaðið 1993, 79(9):349-58en
dc.identifier.issn0023-7213-
dc.identifier.urihttp://hdl.handle.net/2336/78457-
dc.descriptionNeðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Openen
dc.description.abstractThe diagnosis of BOOP is based on characteristic changes on lung biopsy in patients with a variety of symptoms and radiographic changes. We studied nineteen patients, ten males and nine females, with biopsy proven BOOP. The most common clinical findings were fever, shortness of breath and non-productive cough for less than eight weeks and inspiratory crackles on auscultation. Laboratory tests often revealed increased erythrocyte sedimentation rate, low grade anemia, moderate increase in white blood cell count and arterial hypoxemia. Irregular alveolar infiltrates were the most common radiographic abnormalities. Open lung biopsy was required in three. Seven patients in our study were considered to have idiopathic or primary BOOP with no identifiable cause. Twelve patients had either an underlying bacterial lung infection, rheumatologic disease or cancer. Thirteen patients received corticosteroid treatment, usually oral prednisolone at an initial dose of 30-60 mg/day, for a variable length of time. Predisolone treatment resulted in recovery with clearing of lung infiltrates in all patients but one, who died of myocardial infarction five days after treatment was begun. However relapses occurred in more than half (57%) of those receiving prednisolone. Relapses usually occurred when the prednisolone doses had been reduced below 15 mg/day, and in patients who had been treated for up to 10 months. Recovery ensued when perdnisolone doses were increased. Four patients recovered after treatment with antibiotics alone. BOOP probably represents a non-specific inflammatory response of the lung to a number of insults. The high proportion of cases with an established underlying disease in our study is unique. Our data also suggest that infection may be the most frequent underlying condition in BOOP. Corticosteroids were effective treatment but relapses were common. A thorough search for an underlying disease is warranted, and if recognized, should be treated accordingly.en
dc.description.abstractBandvefsmyndandi berkjungateppa með lungnabólgu (Bronchiolitis Obliterans Organizing Pneumonia - BOOP) er sjúkdómsgreining byggð á sérkennandi vefjabreytingum í lungum, sem fyrst var lýst af Lange árið 1901 (1). Á undanförnum áratug hefur orðið ljóst að þessum breytingum fylgja oft sérkennandi sjúkdómseinkenni og breytingar á röntgenmynd (2,3)- BOOP hefur því í vaxandi mæli verið skilgreind sem sérstakt sjúkdómsástand. Þessi áhersla á BOOP sem sjálfstæðan sjúkdóm hefur hagnýta þýðingu, því að BOOP hefur svarað barksterameðferð mun betur en aðrir bandvefsmyndandi bólgusjúkdómar í lungum. Í fyrri rannsóknum hefur í fæstum tilfellum fundist orsök fyrir BOOP-breytingum og sjúkdómurinn því talinn vera af óþekktum orsökum (2-7). Það er þó vel þekkt að BOOP-breytingar greinast í tengslum við aðra sjúkdóma, svo sem sýkingar, liðagigt, krabbamein, geislun og fleira (8-10).en
dc.language.isoisen
dc.publisherLæknafélag Íslands, Læknafélag Reykjavíkuren
dc.relation.urlhttp://www.laeknabladid.isen
dc.subjectÖndunarfærasjúkdómaren
dc.subjectLunguen
dc.subjectLungnabólgaen
dc.subject.meshBronchiolitis Obliterans Organizing Pneumoniaen
dc.subject.meshLung Diseasesen
dc.subject.meshIcelanden
dc.titleBandvefsmyndandi berkjungateppa með lungnabólgu : klínísk sérkenni 19 sjúklinga á Íslandiis
dc.title.alternativeBronchiolitis obliterans organizing pneumonia (BOOP). A clinico-pathologic studyen
dc.typeArticleen
dc.identifier.journalLæknablaðiðen
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