Age related macular degeneration in monozygotic twins and their spouses in Iceland

2.50
Hdl Handle:
http://hdl.handle.net/2336/79214
Title:
Age related macular degeneration in monozygotic twins and their spouses in Iceland
Authors:
Gottfredsdottir, M S; Sverrisson, T; Musch, D C; Stefansson, E
Citation:
Acta Ophthalmol Scand. 1999, 77(4):422-5
Issue Date:
1-Aug-1999
Abstract:
PURPOSE: To examine the importance of genetic factors in age-related macular degeneration by using a twin study to compare the concordance of age-related macular degeneration in monozygotic twin pairs and their spouses. METHODS: This was a prospective study that included 50 twin pairs and 47 spouses. Zygosity was determined by genetic laboratory testing. Macular findings were graded based on the grading system used by the Macular Photocoagulation Study Group and the International ARM Epidemiological Study Group. RESULTS: The concordance of age-related macular degeneration was 90% in monozygotic twin pairs which significantly exceeded that of twin/spouse pairs (70.2%); p=0.0279. In the nine pairs that were concordant, fundus appearance and visual impairment were similar. Environmental factors and medical history were essentially the same in the twin pairs. CONCLUSION: The statistically significant higher concordance of age-related macular degeneration in monozygotic twins compared to their spouses strongly suggests the importance of genetic factors.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www3.interscience.wiley.com/journal/120774522/abstract

Full metadata record

DC FieldValue Language
dc.contributor.authorGottfredsdottir, M S-
dc.contributor.authorSverrisson, T-
dc.contributor.authorMusch, D C-
dc.contributor.authorStefansson, E-
dc.date.accessioned2009-08-28T15:07:18Z-
dc.date.available2009-08-28T15:07:18Z-
dc.date.issued1999-08-01-
dc.date.submitted2009-08-28-
dc.identifier.citationActa Ophthalmol Scand. 1999, 77(4):422-5en
dc.identifier.issn1395-3907-
dc.identifier.pmid10463414-
dc.identifier.doi10.1034/j.1600-0420.1999.770413.x-
dc.identifier.urihttp://hdl.handle.net/2336/79214-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPURPOSE: To examine the importance of genetic factors in age-related macular degeneration by using a twin study to compare the concordance of age-related macular degeneration in monozygotic twin pairs and their spouses. METHODS: This was a prospective study that included 50 twin pairs and 47 spouses. Zygosity was determined by genetic laboratory testing. Macular findings were graded based on the grading system used by the Macular Photocoagulation Study Group and the International ARM Epidemiological Study Group. RESULTS: The concordance of age-related macular degeneration was 90% in monozygotic twin pairs which significantly exceeded that of twin/spouse pairs (70.2%); p=0.0279. In the nine pairs that were concordant, fundus appearance and visual impairment were similar. Environmental factors and medical history were essentially the same in the twin pairs. CONCLUSION: The statistically significant higher concordance of age-related macular degeneration in monozygotic twins compared to their spouses strongly suggests the importance of genetic factors.en
dc.language.isoenen
dc.publisherBlackwellen
dc.relation.urlhttp://www3.interscience.wiley.com/journal/120774522/abstracten
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshDiseases in Twinsen
dc.subject.meshFemaleen
dc.subject.meshGenotypeen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshMacular Degenerationen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshProspective Studiesen
dc.subject.meshRetinaen
dc.subject.meshRisk Factorsen
dc.subject.meshSpousesen
dc.subject.meshTwins, Monozygoticen
dc.titleAge related macular degeneration in monozygotic twins and their spouses in Icelanden
dc.typeArticleen
dc.contributor.departmentDepartment of Ophthalmology, University of Michigan School of Medicine, Kellogg Eye Center, Ann Arbor, USA.en
dc.identifier.journalActa ophthalmologica Scandinavicaen

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