Pseudoexfoliation in the reykjavik eye study: five-year incidence and changes in related ophthalmologic variables.

2.50
Hdl Handle:
http://hdl.handle.net/2336/81094
Title:
Pseudoexfoliation in the reykjavik eye study: five-year incidence and changes in related ophthalmologic variables.
Authors:
Arnarsson, Arsaell; Damji, Karim F; Sasaki, Hiroshi; Sverrisson, Thordur; Jonasson, Fridbert
Citation:
Am. J. Ophthalmol. 2009, 148(2):291-7
Issue Date:
1-Aug-2009
Abstract:
PURPOSE: To examine the 5-year incidence of pseudoexfoliation (PEX) and monitor changes in related ophthalmologic variables. DESIGN: Population-based, prospective cohort study. METHODS: A random sample from the Reykjavik Population Census for persons 50 years and older was used. At baseline 1,045 participants were examined for signs of PEX including peripheral band and/or central shield of exfoliative material on the anterior lens capsule. Five years later, 846 (88.2%) of survivors returned for a follow-up visit. RESULTS: The 5-year incidence of PEX was 3.5% in right eyes only, and 5.2% in either eye. Age increased the risk of 5-year incidence by 5% when looking at 10-year age groups (P = .02); the incidence was higher in female subjects (P = .05) than in male. A total of 27% of clinically asymmetric cases converted to clinically bilateral disease over 5 years. Intraocular pressure increased in the group that developed PEX during the 5 years, but the size of the optic cup increased most in eyes that already had PEX at baseline. CONCLUSION: This incidence study from Iceland confirms findings from previous prevalence studies that PEX is increasingly common with older age in this population. Earliest changes related to PEX may be subtle and difficult to detect, which may lead to some misclassification. Further study is needed to identify clinical features that can reliably detect patients at risk for developing PEX.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1016/j.ajo.2009.03.021

Full metadata record

DC FieldValue Language
dc.contributor.authorArnarsson, Arsaell-
dc.contributor.authorDamji, Karim F-
dc.contributor.authorSasaki, Hiroshi-
dc.contributor.authorSverrisson, Thordur-
dc.contributor.authorJonasson, Fridbert-
dc.date.accessioned2009-09-15T13:31:08Z-
dc.date.available2009-09-15T13:31:08Z-
dc.date.issued2009-08-01-
dc.date.submitted2009-09-15-
dc.identifier.citationAm. J. Ophthalmol. 2009, 148(2):291-7en
dc.identifier.issn1879-1891-
dc.identifier.pmid19427619-
dc.identifier.doi10.1016/j.ajo.2009.03.021-
dc.identifier.urihttp://hdl.handle.net/2336/81094-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPURPOSE: To examine the 5-year incidence of pseudoexfoliation (PEX) and monitor changes in related ophthalmologic variables. DESIGN: Population-based, prospective cohort study. METHODS: A random sample from the Reykjavik Population Census for persons 50 years and older was used. At baseline 1,045 participants were examined for signs of PEX including peripheral band and/or central shield of exfoliative material on the anterior lens capsule. Five years later, 846 (88.2%) of survivors returned for a follow-up visit. RESULTS: The 5-year incidence of PEX was 3.5% in right eyes only, and 5.2% in either eye. Age increased the risk of 5-year incidence by 5% when looking at 10-year age groups (P = .02); the incidence was higher in female subjects (P = .05) than in male. A total of 27% of clinically asymmetric cases converted to clinically bilateral disease over 5 years. Intraocular pressure increased in the group that developed PEX during the 5 years, but the size of the optic cup increased most in eyes that already had PEX at baseline. CONCLUSION: This incidence study from Iceland confirms findings from previous prevalence studies that PEX is increasingly common with older age in this population. Earliest changes related to PEX may be subtle and difficult to detect, which may lead to some misclassification. Further study is needed to identify clinical features that can reliably detect patients at risk for developing PEX.en
dc.language.isoenen
dc.publisherElsevier Scienceen
dc.relation.urlhttp://dx.doi.org/10.1016/j.ajo.2009.03.021en
dc.subject.meshAge Distributionen
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshExfoliation Syndromeen
dc.subject.meshFemaleen
dc.subject.meshFollow-Up Studiesen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshIncidenceen
dc.subject.meshIntraocular Pressureen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshProspective Studiesen
dc.subject.meshSex Distributionen
dc.titlePseudoexfoliation in the reykjavik eye study: five-year incidence and changes in related ophthalmologic variables.en
dc.typeArticleen
dc.contributor.departmentDepartment of Ophthalmology, University of Iceland, Reykjavik, Iceland.en
dc.identifier.journalAmerican journal of ophthalmologyen

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